251924-83-1

Basic information

• Product Name: 1-tert-butyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate
• Synonyms: 1-tert-butyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate;N-Boc-DL-pyroglutamic acid ethyl ester
• CAS NO: 251924-83-1
• Molecular Formula: C12H19NO5
• Molecular Weight: 257.28296
• Mol File: 251924-83-1.mol

Chemical Properties

• Boiling Point: 375.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.182±0.06 g/cm3(Predicted)
• PKA: -4.15±0.40(Predicted)
• CAS DataBase Reference: 1-tert-butyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-tert-butyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate(251924-83-1)
• EPA Substance Registry System: 1-tert-butyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate(251924-83-1)

Safety Data

• Hazardous Substances Data: 251924-83-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-tert-butyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate is used as a building block for the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and functional groups make it a valuable component in the development of new drug candidates and therapeutic agents.
Used in Medicinal Chemistry:
1-tert-butyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate is used as a key intermediate in the production of various chemical compounds. Its potential therapeutic properties have been studied for its application in the treatment of various diseases and disorders, making it a promising candidate for further research and development in the field of medicinal chemistry.
Used in Organic Synthesis:
1-tert-butyl 2-ethyl 5-oxopyrrolidine-1,2-dicarboxylate is used as a versatile building block in organic synthesis. Its unique structure and functional groups allow for the creation of a wide range of chemical compounds, making it a valuable resource for chemists and researchers in the field of organic synthesis.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 7149-65-7 ethyl (S)-pyroglutamate 
• 66183-71-9 ethyl 2-oxopyrrolidine-5-carboxylate 
• 149-87-1 Pyroglutamic acid 
• 86938-17-2 2-(S)-tert-butoxycarbonylaminopentanedioic acid 1-ethyl ester 
• 52454-78-1 L-glutamic acid α-ethyl ester 
• 1118-89-4 diethyl-L-glutamate hydrochloride 
• 24608-52-4 tert-butyl chloroformate 
• 64-17-5 ethanol 
• 98-79-3 L-Pyroglutamic acid 
• 122-51-0 orthoformic acid triethyl ester 
• 4042-36-8 D-pyrrolidone-5-carboxylic acid 
• 1538-75-6 2,2-dimethylpropanoic anhydride 
• 68766-96-1 ethyl (R)-2-pyrrolidone-5-carboxylate 

Downstream Products

• 153080-88-7 ethyl (2S,4R)-1-(tert-butoxycarbonyl)-4-(p-trifluoromethyl)benzylpyroglutamate 
• 881683-80-3 ethyl (2S)-N-Boc-2-amino-5-oxo-non-8-enoate 
• 158392-80-4 1-tert-butyl 2-ethyl (2S)4,4-dimethyl-5-oxopyrrolidine-1,2-dicarboxylate 
• 144978-14-3 (Z)-(S)-2-tert-Butoxycarbonylamino-7-hydroxy-7-(3-methoxy-phenyl)-5-oxo-hept-6-enoic acid ethyl ester 
• 144978-13-2 (Z)-(S)-2-tert-Butoxycarbonylamino-7-hydroxy-5-oxo-7-phenyl-hept-6-enoic acid ethyl ester 
• 153080-81-0 (2S,4R)-1-tert-butyl 4-allyl-2-ethoxycarbonyl-5-oxopyrrolidine-1-carboxylate 
• 194594-23-5 5-hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester 
• 144978-17-6 (S)-2-tert-Butoxycarbonylamino-6-(diethoxy-phosphoryl)-5-oxo-hexanoic acid ethyl ester 
• 1792180-81-4 (-) 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one 

Relevant articles and documents

INHIBITORS OF NOROVIRUS AND CORONAVIRUS REPLICATION

Compounds of Formula (I) and methods of inhibiting the replication of viruses in a biological sample or patient, of reducing the amount of viruses in a biological sample or patient, and of treating a virus infection in a patient, comprising administering to said biological sample or patient an effective amount of a compound represented by Formula (I), a compound of Table A or B or a pharmaceutically acceptable salt thereof.

Preparation method of (s)-1-(t-butyloxycarboryl)-5-oxopyrrolidine-2-carboxylic acid ethyl ester

The invention discloses a preparation method of (s)-1-(t-butyloxycarboryl)-5-oxopyrrolidine-2-carboxylic acid ethyl ester and aims at mainly solving the technical problems of complexity, long period,high cost, low yield and the like in the original technology. In the technical scheme of the invention, the preparation method comprises the following steps of step 1, preparation of boc-glu-oet: mixing h-glu-oet with a protective agent of boc- groups to prepare the boc-glu-oet, or mixing boc-glu-oh with ethyl acetate, performing reaction on a mixture under the action of diazoalkane, and performing treatment to obtain the boc-glu-oet; step 2, preparation of carboxyl active ester of the boc-glu-oet: mixing the boc-glu-oet with a carboxyl activating reagent, and performing low-temperature reaction on a mixture under the action of condensing agent to prepare a carboxyl activator of the boc-glu-oet; and sep 3, preparation of boc-pyr-oet: performing intramolecular cyclization on the carboxyl activator of the boc-glu-oet to prepare a crude product, and then performing extraction, purification and crystallization to obtain a target product. The preparation method provided by the invention greatly simplifies the process route, lowers the cost and is suitable for mass production.

Green preparation method of N-substituted-L-pyroglutamate

The invention provides a green preparation method of N-substituted-L-pyroglutamate. The method comprises the steps as follows: L-glutamic acid diester hydrochloride (III) is prepared from L-glutamic acid (II) as a starting material in the presence of an acidic reagent by an esterification reaction; then, L-glutamic acid diester hydrochloride (III) is subjected to N-substituted protective reactionwith an N-substituent protective reagent with a one-pot method in the presence of a base and a solvent, an N-substituted protective group is introduced, heating is performed for dealcoholization cyclization in molecules, and N-substituted-L-pyroglutamate as shown in the formula (I) is obtained. The method has the advantages of cheap and easily available raw materials, classic reaction types, shortprocess route, simple and convenient operation, small waste water amount, green and environment-friendly production process, high reaction yield and low product cost. 5R-benzyloxyaminopiperidine-2S-carboxylate, 5R-benzyloxyaminopiperidine-2S-formate ethanedioate and avibactam can be prepared from N-substituted-L-pyroglutamate as shown in the formula (I).

POLYMYXIN ANALOGS USEFUL AS ANTIBIOTIC POTENTIATORS

The disclosure provides compounds of the formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt of either of the foregoing. The variables A, R1, and R2 are defined in the disclosure. The disclosure further includes pharmaceutical compositions comprising a compound of formula I together with at least one pharmaceutically acceptable carrier. The disclosure also includes a method of sensitizing bacteria to an antibacterial agent, comprising administering to a patient infected with the bacteria, simultaneously or sequentially, a therapeutically effective amount of the antibacterial agent and a compound of formula (I).

PROCESS FOR PREPARING DIPEPTIDYL PEPTIDASE IV INHIBITORS AND INTERMEDIATES THEREFOR

A process for preparing an amine of the structure which comprises a. treating an aqueous solution of a keto acid of the structure with ammonium formate, nicotinamide adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase and/or formate dehydrogenase enzyme (PDH/FDH); and b. adjusting pH of the reaction mixture with sodium hydroxide to form the desired amine which is substantially free of undesirable excess ammonium ions.

Proline compounds as Granzyme B inhibitors

Proline compounds as Granzyme B inhibitors, compositions that include the compounds, and methods for using the compounds. Methods for treating cutaneous scleroderma, epidermolysis bullosa, radiation dermatitis, alopecia areata, and discoid lupus erythematosus are provided.

Protected amino hydroxy adamantane carboxylic acid and process for its preparation

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SPIRO COMPOUNDS AS HEPATITIS C VIRUS INHIBITORS

Disclosed are spiro compounds of formula (I), or stereomers, geometric isomers, tautomers, nitrogen oxides, hydrates, solvates, metabolites, pharmaceutically acceptable salts or prodrugs thereof. The compounds can be used to treat hepatitis C virus (HCV) infection or hepatitis C disease. Furthermore disclosed are pharmaceutical compositions containing the compounds and the method of using the compounds or pharmaceutical compositions in the treatment of HCV infection or hepatitis C disease.

CYCLIC AMINE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS

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Structural Properties and Stereochemically Distinct Folding Preferences of 4,5-cis and trans-Methano- L -Proline Oligomers: The Shortest Crystalline PPII-Type Helical Proline-Derived Tetramer

The synthesis, structural properties, and folding patterns of a series of L-proline methanologues represented by cis- and trans-4,5-methano-L-proline amides and their oligomers are reported as revealed by X-ray crystallography, circular dichroism measurements, and DFT calculations. We disclose the first example of a crystalline tetrameric proline congener to exhibit a polyproline II helical conformation. Experimental evidence of PPII-type helical arrangement (both in solution and in the solid state) of cis-4,5-methano-L-proline oligomers is supported by theoretical calculations reflecting the extent of n→π? stabilization of the trans-amide conformation.