252574-03-1

Basic information

• Product Name: (3S,4S)-N-Boc-3-(benzylamino)-4-hydroxypyrrolidine
• Synonyms: (3s,4s)-n-boc-3-(benzylamino)-4-hydroxypyrrolidine;(3S,4S)-3-Hydroxy-4-[(phenylmethyl)amino]-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester;(3S,4S)-tert-Butyl 3-(benzylamino)-4-hydroxypyrrolidine-1-carboxylate;hydroxypyrrolidine-1-carboxylate;(3S,4S)-N-Boc-3-(benzylamino)-4-hydroxypyrrolidine-4;tert-butyl (3S,4S)-3-(benzylamino)-4-hydroxypyrrolidine-1-carboxylate
• CAS NO: 252574-03-1
• Molecular Formula: C₁₆H₂₄N₂O₃
• Molecular Weight: 292.37
• Mol File: 252574-03-1.mol

Chemical Properties

• Boiling Point: 424.6°C at 760 mmHg
• Flash Point: 210.6°C
• Appearance: /
• Density: 1.16
• Vapor Pressure: 5.77E-08mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: 2-8°C(protect from light)
• PKA: 14.24±0.40(Predicted)
• CAS DataBase Reference: (3S,4S)-N-Boc-3-(benzylamino)-4-hydroxypyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,4S)-N-Boc-3-(benzylamino)-4-hydroxypyrrolidine(252574-03-1)
• EPA Substance Registry System: (3S,4S)-N-Boc-3-(benzylamino)-4-hydroxypyrrolidine(252574-03-1)

Safety Data

• Hazardous Substances Data: 252574-03-1(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(3S,4S)-N-Boc-3-(benzylamino)-4-hydroxypyrrolidine is used as a building block for the synthesis of more complex molecules, leveraging its unique structure and chiral properties to create a wide range of compounds with diverse applications.
Used in Medicinal Chemistry:
(3S,4S)-N-Boc-3-(benzylamino)-4-hydroxypyrrolidine is used as a starting material for the development of new pharmaceuticals, owing to its potential to be incorporated into drug candidates with specific therapeutic properties.
Used in Chemical Biology:
(3S,4S)-N-Boc-3-(benzylamino)-4-hydroxypyrrolidine is employed as a chiral compound in chemical biology research, where it can be utilized to study the interactions of biomolecules and develop novel biological probes.

InChI:InChI=1/C16H24N2O3/c1-16(2,3)21-15(20)18-10-13(14(19)11-18)17-9-12-7-5-4-6-8-12/h4-8,13-14,17,19H,9-11H2,1-3H3/t13-,14-/m0/s1

Upstream product

• 4248-19-5 tert-butyl carbazate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 73286-70-1 N-(tert-butoxycarbonyl)-3-pyrroline 
• 114214-49-2 1-tert-butoxycarbonyl-3,4-epoxypyrrolidine 
• 252574-02-0 (±)-trans-tert-butyl 3-bromo-4-hydroxypyrrolidine-1-carboxylate 
• 252574-04-2 (3S,4S)-3-benzylamino-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester (+)-mandelic acid salt 

Downstream Products

• 190792-74-6 (3S,4S)-4-amino-1-N-tert-butyloxycarbonyl-3-hydroxypyrrolidine 
• 859213-33-5 (3S,4S)-tert-butyl 3-(dimethyl amino)-4-hydroxypyrrolidine-1-carboxylate 
• 1009075-43-7 (3S,4S)-tert-butyl 3-amino-4-fluoropyrrolidine-1-carboxylate 
• 1174020-30-4 cis-3-amino-4-fluoropyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Asymmetric Synthesis of cis -(S, R)-3-Amino-4-fluoro-1-methylpyrrolidine

The development of the stereoselective synthesis of cis -(S, R)-3-amino-4-fluoro-1-methylpyrrolidine is described starting from chiral, non-racemic 1-[(3 S,4 S)-3-azido-4-hydroxypyrrolidin-1-yl]-2,2,2-trifluoroethan-1-one. Two sets of deoxyfluorination co

FUSED QUADRACYCLIC COMPOUNDS, COMPOSITIONS AND USES THEREOF

Provided herein are substituted fused quadracyclic compounds useful as inhibitors of MK2. The invention further provides pharmaceutical compositions of the compounds of the invention. The invention also provides medical uses of substituted fused quadracyclic compounds.

MINERALOCORTICOID RECEPTOR ANTAGONISTS AND METHODS OF USE

The present invention provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly congestive heart failure, hypertension, diabetic nephropathy, or chronic kidney disease, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Practical synthesis of (3S,4S)-3-methoxy-4-methylaminopyrrolidine

Three synthetic methods for the preparation of (3S,4S)-3-methoxy-4-methylaminopyrrolidine, an important intermediate in the synthesis of the novel quinolone antitumur agent, AG-7352, have been developed. By one route, an efficient and large-scale preparation of the chiral pyrrolidine could be achieved through resolution of (±)-1-Boc-3-benzylamino-4-hydroxypyrrolidine, which is prepared from either 3-pyrroline or 1,4-dichloro-2-butene.