252644-60-3

Basic information

• Product Name: 1-[BIS-(4-FLUOROPHENYL)-METHYL]-PIPERIDINE
• Synonyms: 1-[BIS-(4-FLUOROPHENYL)-METHYL]-PIPERIDINE
• CAS NO: 252644-60-3
• Molecular Formula: C₁₈H₁₉F₂N
• Molecular Weight: 287.35
• Mol File: 252644-60-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-[BIS-(4-FLUOROPHENYL)-METHYL]-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[BIS-(4-FLUOROPHENYL)-METHYL]-PIPERIDINE(252644-60-3)
• EPA Substance Registry System: 1-[BIS-(4-FLUOROPHENYL)-METHYL]-PIPERIDINE(252644-60-3)

Safety Data

• Hazardous Substances Data: 252644-60-3(Hazardous Substances Data)

Usage

Chemical structure

A piperidine derivative with two 4-fluorophenyl substituents attached to the piperidine ring.

Application

Commonly used in organic synthesis and pharmaceutical research as a building block for the production of various drug candidates and bioactive molecules.

Usage in analytical chemistry

May be used as a reference standard in analytical chemistry and spectroscopy.

Unique properties

The presence of fluorine substituents on the phenyl rings can impart unique chemical and biological properties to this compound.

Potential for further investigation

Due to its unique properties, it is of interest for further investigation and potential application in drug development and other fields.

Upstream product

• 2591-86-8 N-Formylpiperidine 
• 352-13-6 4-flourophenylmagnesium bromide 
• 68925-78-0 1,1'-((4-fluorophenyl)methylene)dipiperidine 
• 1765-93-1 4-fluoroboronic acid 
• 459-57-4 4-fluorobenzaldehyde 
• 110-89-4 piperidine 

Relevant articles and documents

Copper(I)-catalyzed coupling reaction of aryl boronic acids with N,O-acetals and N,N-aminals under atmosphere leading to α-aryl glycine derivatives and diarylmethylamine derivatives

We demonstrated a copper(I)-catalyzed coupling reaction of aryl boronic acids with N,O-acetals and N,N-aminals leading to the synthesis of α-aryl glycines and diarylmethylamines. Under an ambient atmosphere, this catalytic system could be applied to the activation of a C(sp3)-O bond of N,O-acetals with an ester and an aryl group, or without a coordinating substituent, as well as to a C(sp3)-N bond of N,N-aminals.

Synthesis of tertiary sec-alkylamines by the addition of grignard reagents to N,N-dialkylformamides mediated by Ti(OiPr)4 and Me3SiCl

A number of tertiary sec-alkylamines (22 examples, 29-80% yield) have been prepared according to a simple one-pot procedure by the addition of Grignard reagents to N,N-dialkylformamides in the presence of Ti(OiPr)4 and Me3SiCl. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.