1-[BIS-(4-FLUOROPHENYL)-METHYL]-PIPERIDINE

Base Information

• Chemical Name: 1-[BIS-(4-FLUOROPHENYL)-METHYL]-PIPERIDINE
• CAS No.: 252644-60-3
• Molecular Formula: C18H19 F2 N
• Molecular Weight: 287.352
• Mol file: 252644-60-3.mol

Synonyms:1-[Bis(4-fluorophenyl)methyl]piperidine

Chemical Property of 1-[BIS-(4-FLUOROPHENYL)-METHYL]-PIPERIDINE

Chemical Property:

• PSA: 3.24000
• LogP: 4.47800

Purity/Quality:

98% ^*data from raw suppliers

1-[Bis-(4-Fluorophenyl)-methyl]-piperidine 98 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[BIS-(4-FLUOROPHENYL)-METHYL]-PIPERIDINE

There total 4 articles about 1-[BIS-(4-FLUOROPHENYL)-METHYL]-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1,1'-((4-fluorophenyl)methylene)dipiperidine (68925-78-0) + 4-fluoroboronic acid (1765-93-1) → 1-(bis(4-fluorophenyl)methyl)piperidine (252644-60-3)

Guidance literature:

With [2,2]bipyridinyl; copper(I) bromide; In 1,2-dichloro-ethane; at 70 ℃; for 2h; Sealed tube;

DOI:10.1016/j.tet.2015.05.068

Reference yield: 62.0%

N-Formylpiperidine (2591-86-8) + 4-flourophenylmagnesium bromide (352-13-6) → 1-(bis(4-fluorophenyl)methyl)piperidine (252644-60-3)

Guidance literature:

With titanium(IV) isopropylate; chloro-trimethyl-silane; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1002/ejoc.200800629

Reference yield:

4-fluorobenzaldehyde (459-57-4) → 1-(bis(4-fluorophenyl)methyl)piperidine (252644-60-3)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 16 h / 20 °C / Inert atmosphere

2: copper(I) bromide; [2,2]bipyridinyl / 1,2-dichloro-ethane / 2 h / 70 °C / Sealed tube

With [2,2]bipyridinyl; copper(I) bromide; In 1,2-dichloro-ethane; benzene;

DOI:10.1016/j.tet.2015.05.068

upstream raw materials:

N-Formylpiperidine

4-flourophenylmagnesium bromide

1,1'-((4-fluorophenyl)methylene)dipiperidine

4-fluoroboronic acid