252679-72-4

Basic information

• Product Name: 2-Amino-4-phenyl-5-phenylsulfonyl-1,3-thiazole
• Synonyms: 2-Amino-4-phenyl-5-phenylsulfonyl-1,3-thiazole
• CAS NO: 252679-72-4
• Molecular Formula: C15H12N2O2S2
• Molecular Weight: 316.39798
• Mol File: 252679-72-4.mol

Chemical Properties

• Melting Point: 192 °C(Solv: ethanol (64-17-5))
• Boiling Point: 584.7±38.0 °C(Predicted)
• Appearance: /
• Density: 1.387±0.06 g/cm3(Predicted)
• PKA: 1.16±0.10(Predicted)
• CAS DataBase Reference: 2-Amino-4-phenyl-5-phenylsulfonyl-1,3-thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4-phenyl-5-phenylsulfonyl-1,3-thiazole(252679-72-4)
• EPA Substance Registry System: 2-Amino-4-phenyl-5-phenylsulfonyl-1,3-thiazole(252679-72-4)

Safety Data

• Hazardous Substances Data: 252679-72-4(Hazardous Substances Data)

Usage

### Properties

1. Molecular Formula: C17H13N3O2S
2. Chemical Structure: Thiazole derivative
3. Functional Groups:
Amino group (NH2)
Phenyl group (C6H5)
Phenylsulfonyl group (C6H5SO2)

### Specific Content

1. Thiazole Ring:
Known for biological activities
Potential for pharmaceutical applications
2. Amino Group:
Suitable for synthesis of biologically active compounds
Potential for drug development
3. Phenylsulfonyl Group:
Adds to pharmacological potential
Sulfonyl compounds often used in drug discovery and development
4. Chemical Versatility:
Potential applications in pharmaceutical industry

Thiazole Ring

The thiazole ring in 2-Amino-4-phenyl-5-phenylsulfonyl-1,3-thiazole is significant due to its known biological activities. Compounds containing thiazole rings have been explored for various pharmaceutical applications, making this compound valuable in drug research and development.

Amino Group

The presence of an amino group (NH2) makes this compound suitable for creating biologically active molecules. This group is often used as a building block in the synthesis of pharmaceuticals, providing opportunities for the development of new drugs with specific biological targets.

Phenylsulfonyl Group

The phenylsulfonyl group (C6H5SO2) further enhances the pharmacological potential of 2-Amino-4-phenyl-5-phenylsulfonyl-1,3-thiazole. Sulfonyl compounds are commonly used in medicinal chemistry due to their ability to interact with specific biological targets, potentially leading to the discovery of novel therapeutic agents.

Chemical Versatility

Overall, 2-Amino-4-phenyl-5-phenylsulfonyl-1,3-thiazole exhibits chemical versatility, with potential applications spanning the pharmaceutical industry. Its combination of functional groups offers a platform for the creation of diverse molecules with varying biological activities, making it an interesting target for drug design and development.

Upstream product

• 23128-59-8 ω-bromo-ω-phenylsulfonylacetophenone 
• 17356-08-0 thiourea 
• 3406-03-9 2-(phenylsulfonyl)acetophenone 
• 873-55-2 sodium benzenesulfonate 
• 98-86-2 acetophenone 

Relevant articles and documents

Selenium heterocycles. XLIII. Syntheses of 3,5-diaryl-1,2,4- thiadiazoles and 3,5-diaryl-1,2,4-selenadiazoles

Starting from readily available α-arylsulfonyl-α- bromoacetophenones 2 a series of 3,5-diaryl-1,2,4-thiadiazoles and 3,5-diaryl-1,2,4-selenadiazoles were prepared in moderate yield. Reaction of compounds 2 with thiourea or selenourea gave 2-amino-5-arylsu

Rapid and convenient synthetic strategy for 2-amino-4-aryl-5-aryl-sulfonyl thiazoles

Synthesis of 2-amino-4-aryl-5-arylsulfonyl thiazoles 2a-i have been successfully carried out in one pot by condensing α-aryl sulfonyl-4-substituted acetophenones with phenyl trimethyl ammonium tribromide (PTT) and thiourea. The required α-aryl sulfonyl-4-substituted acetophenones have also been prepared by modified one pot method.