253-45-2

Basic information

• Product Name: 2,7-Naphthyridine(7CI,8CI,9CI)
• Synonyms: 2,7-Naphthyridine(7CI,8CI,9CI);2,7-Naphthyridine;2,7-Diazanaphthalene
• CAS NO: 253-45-2
• Molecular Formula: C₈H₆N₂
• Molecular Weight: 130.15
• Product Categories: PYRIDINE
• Mol File: 253-45-2.mol

Chemical Properties

• Melting Point: 96-97 °C
• Boiling Point: 286℃
• Flash Point: 108℃
• Appearance: /
• Density: 1.183
• Vapor Pressure: 0.00453mmHg at 25°C
• Refractive Index: 1.653
• Storage Temp.: 2-8°C
• PKA: 4.00±0.10(Predicted)
• CAS DataBase Reference: 2,7-Naphthyridine(7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,7-Naphthyridine(7CI,8CI,9CI)(253-45-2)
• EPA Substance Registry System: 2,7-Naphthyridine(7CI,8CI,9CI)(253-45-2)

Safety Data

• Hazardous Substances Data: 253-45-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
2,7-Naphthyridine is used as a building block in the synthesis of pharmaceuticals and other bioactive compounds. Its unique structure and properties make it a valuable component in the development of new drugs.
Used in Medicinal Chemistry:
2,7-Naphthyridine exhibits antiviral, antimicrobial, and anticancer properties, making it a useful compound for drug discovery and development. Its diverse biological activities contribute to its potential as a therapeutic agent in various medical applications.
Used in Materials Science:
2,7-Naphthyridine has been studied for its potential use in materials science. It can be used as a ligand in coordination chemistry, enabling the synthesis of new functional materials with unique properties and applications.
Used in Organic Synthesis:
2,7-Naphthyridine is a versatile compound in organic synthesis, serving as a key intermediate for the preparation of various organic compounds. Its reactivity and stability make it a valuable component in the synthesis of complex organic molecules.

InChI:InChI=1/C8H6N2/c1-3-9-5-8-6-10-4-2-7(1)8/h1-6H

Upstream product

• 69042-30-4 1-chloro-[2,7]naphthyridine 
• 222167-81-9 4-((trimethylsilyl)ethynyl)nicotinaldehyde 
• 100135-62-4 3-Dicyanmethylen-glutarsaeure-diaethylester 
• 105-50-0 diethyl 1,3-acetonedicarboxylate 
• 1120-87-2 4-bromopyridin 
• 154105-64-3 4-bromonicotinaldehyde 
• 3222-50-2 4-methylnicotinic acid 
• 67988-50-5 2,7-naphthyridinyl-1(2H)-one 
• 6790-32-5 3,4-dihydro-1H-pyrano[3,4-c]pyridin-1-one 
• 853648-79-0 4-(2-hydroxy-ethyl)-nicotinic acid amide 
• 517-40-8 4-methyl-2,3-pyridinedicarboxylic acid 

Downstream Products

• 108749-08-2 1,2,3,4-tetrahydro-2,7-naphthyridine 

Relevant articles and documents

A rigid cavity containing tetra-cobalt(III) [2 × 2] grid complex

The synthesis and structure of a rigid, cavity containing tetra-cobalt(III) [2 × 2] grid complex using an unusual bis(bipyridine)dimethoxynaphthyridine ligand is described.

One-pot homo- and cross-coupling of diazanaphthalenes via C-H substitution: Synthesis of Bis- and Tris-diazanaphthalenes

The transition metal-free coupling reactions of unactivated diazanaphthalenes were studied using only lithium tetramethylpiperidine (LiTMP) reagent. Symmetrical and nonsymmetrical bis-diazanaphthalenes were synthesized in moderate to high yield by homo- and cross-coupling of related monomers. In addition, the single-step synthesis of diquinoxalino [2,3-a: 2', 3'c] phenazine and 2,2': 3', 2″ - terquinoxaline using the appropriate equivalent amount of LiTMP was performed. The products were characterized by means of NMR spectroscopy and HRMS spectrometry.

4-Piperidinecarboxamide modulators of vanilloid VR1 receptor

This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to hetero isonipecotic amides that are potent modulators of VR1 which are useful for the treatment and prevention of disease conditions in mammals.

General synthetic method for naphthyridines and their N-oxides containing isoquinolinic nitrogen

Substituted naphthyridines containing isoquinolinic nitrogen were synthesized by the reaction of o-ethynylpyridinecarbaldehydes with ammonia. The synthesis of their N-oxides was also achieved by a basic cyclization reaction of the same pyridine derivatives via the corresponding oximes.

The amination of halogeno-2,7- and 1,8-naphthyridines

The conversion of 1-halogeno-2,7-naphthyridines into the corresponding 1-amino compounds with KNH2/NH3, is shown, by the use of deuterated starting compounds, to proceed via an SN(AE)ipso substitution and not via an SN(AE)tele mechanism, even though convincing evidence for the formation of tele ?-adduct, 8-amino-1-halogeno-dihydro-2,7-naphthyridine, was obtained.Using the same methods, it is shown that the conversion of 2-bromo-1,8-naphthyridine into 2-amino-1,8-naphthyridine proceds, to the extent of 40percent via an odd SN(AE)tele pathway.