- QUINUCLIDINONE ANALOGUES AS ANTICANCER AGENTS
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The disclosure includes compounds of Formula (I) and Formula(A) wherein R1, R2, R3, m, n, k, and L are defined herein. Also disclosed are methods for treating a neoplastic disease, autoimmune disease, or an inflammatory disorder with these compounds.
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Page/Page column 75-76
(2021/08/13)
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- 2 - Methyl pyridine -4 - formic acid pyridine ring reduced to piperidine (by machine translation)
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The invention discloses a method for reducing a pyridine ring to piperidine in 2-picoline-4-formic acid. The method comprises the step one of preparation of 2-picoline-4-ethyl formate, wherein the initiator 2-picoline-4-formic acid is dissolved into ethyl alcohol solvent, thionyl chloride is dropped into the mixture to carry out esterification reaction to obtain esterification product mixing liquid, and after-treatment is carried out on the esterification product mixing liquid to obtain the 2-picoline-4-ethyl formate; the step two of reduction reaction, wherein the 2-picoline-4-ethyl formate generated through the reaction in the former step is pressurized under the effect of a catalyst, hydrogen is introduced into the 2-picoline-4-ethyl formate to carry out reduction reaction to obtain a reduction product mixing liquid, the addition quantity of the catalyst is 10%-20% of the content of the initiator, and the catalyst is a mixture of palladium carbon and rhodium carbon; the step three of after-treatment, wherein the reaction product mixing liquid reacted in the step two is treated to obtain a 2-picoline-4-ethyl formate product. The new method for producing the 2-picoline-4-ethyl formate has the advantages of being high in efficiency, high in reaction speed and simple in process.
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Paragraph 0020; 0022-0025
(2019/01/05)
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- Synthesis of Functionalized Pyridines via a Regioselective Oxazoline Promoted C-H Amidation Reaction
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The first Rh-catalyzed C-H amidation of pyridines is reported. The incorporation of a substituent at the C2 position both is crucial to the success of this transformation and provides considerable scope for further elaboration of the resulting products. Among these compounds, 2-chloropyridines allow access to a selection of intermediates including a versatile azaquinazoline scaffold.
- Maiden, Tracy M. M.,Swanson, Stephen,Procopiou, Panayiotis A.,Harrity, Joseph P. A.
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supporting information
p. 3434 - 3437
(2016/07/26)
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