84589-39-9

Basic information

• Product Name: 4-Pyridinecarboxamide,2-(hydroxymethyl)-(9CI)
• Synonyms: 4-Pyridinecarboxamide,2-(hydroxymethyl)-(9CI);4-Pyridinecarboxamide,2-(hydroxymethyl);2-Hydroxymethyl-isonicotinamide
• CAS NO: 84589-39-9
• Molecular Formula: C7H8N2O2
• Molecular Weight: 152.15
• Product Categories: AMIDE
• Mol File: 84589-39-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Pyridinecarboxamide,2-(hydroxymethyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridinecarboxamide,2-(hydroxymethyl)-(9CI)(84589-39-9)
• EPA Substance Registry System: 4-Pyridinecarboxamide,2-(hydroxymethyl)-(9CI)(84589-39-9)

Safety Data

• Hazardous Substances Data: 84589-39-9(Hazardous Substances Data)

Upstream product

• 98996-32-8 2-methyl-1-oxy-isonicotinic acid ethyl ester 
• 915140-06-6 2-(hydroxymethyl)isonicotinic acid 
• 142074-49-5 2-(ethoxycarbonyl)isonicotinic acid 
• 499-80-9 pyridine-2,4-dicarboxylic acid 
• 25635-17-0 ethyl 2-methylpyridine-4-carboxylate 
• 67-56-1 methanol 
• 1453-82-3 isonicotinamide 
• 99856-13-0 2-acetoxymethyl-isonicotinic acid ethyl ester 

Downstream Products

• 51454-64-9 2-Chloromethyl-4-cyanopyridine 

Relevant articles and documents

Modular synthesis and biological activity of pyridyl-based analogs of the potent Class i Histone Deacetylase Inhibitor Largazole

The formation of a series of analogs containing a pyridine moiety in place of the natural thiazole heterocycle, based on the potent, naturally occurring HDAC inhibitor Largazole has been accomplished. The synthetic strategy was designed modularly to access multiple inhibitors with different aryl functionalities containing both the natural depsipeptide and peptide isostere variant of the macrocycle. The cytotoxicity and biochemical activity of the library of HDAC inhibitors is described herein.

Photochemical Alkylation, Hydroxyalkylation, and Alkoxylation of Pyridinecarboxamides in Alcohol

The UV-irradiation of 2- and 4-pyridinecarboxamides in alcohol brings about alkylation and/or hydroxyalkylation in the pyridine ring.In the irradiation of 3-pyridinecarboxamide in the presence of sulfuric acid, ionic reaction (alkoxylation at the 2- and 6-position) and radical reaction (alkylation at the 4- and 6-position) occur in parallel.The effects of quenchers indicate that two alkylation products originate from one excited triplet state which is quenched by energy-transfer mechanism and that two alkoxylation products originate from the excited singlet state.

Radiation-induced Alkylation, Hydroxyalkylation, and Reduction of Pyridinecarboxamides in Acidic Alcoholic Solutions

The γ-irradiation of pyridinecarboxamides in acidic methanol or ethanol brings about substitution of the ring hydrogen by alkyl or hydroxyalkyl groups derived from the solvent alcohols in relatively high G-values.In 2-propanol, little alkylation and hydroxyalkylation occur and reduction of CONH2 to CH2OH occurs in low G-values.