25635-17-0

Usage

Uses

Used in Organic Synthesis:
2-Methylisonicotinic acid ethyl ester is used as a key intermediate in the synthesis of various organic compounds. Its unique structure and reactivity make it a valuable building block for the creation of complex organic molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-Methylisonicotinic acid ethyl ester is used as a starting material for the development of new drugs. Its potential biological activities and chemical properties make it a promising candidate for the discovery of novel therapeutic agents.
Used in Drug Development:
2-Methylisonicotinic acid ethyl ester is employed as a precursor in the synthesis of active pharmaceutical ingredients. Its versatile chemical properties allow for the modification and optimization of drug candidates, leading to the development of more effective and safer medications.
Used in Medical Treatments:
Due to its potential biological activities, 2-Methylisonicotinic acid ethyl ester is being investigated for its use in medical treatments. Its ability to interact with biological targets and modulate cellular processes may contribute to the development of new therapies for various diseases and conditions.

Upstream product

• 4021-11-8 2-methylisonicotinic acid 
• 64-17-5 ethanol 
• 108-47-4 2,4-lutidine 

Downstream Products

• 19354-04-2 2-methyl-isonicotinic acid amide 
• 96486-17-8 1-(2-ethoxy-2-oxoethyl)-4-(ethoxycarbonyl)-2-methylpyridinium bromide 
• 1419402-14-4 C₂₂H₁₆NO₂⁽¹⁺⁾*Br^(1-) 
• 3758-59-6 2-methylisonicotinohydrazide 
• 84589-39-9 2-hydroxymethyl-4-pyridinecarboxamide 
• 3390-77-0 2-methyl-thioisonicotinic acid amide 
• 18615-86-6 2-Methyl-4-hydroxypyridine 
• 18437-58-6 3-methyl-4-pyridinamine 
• 1134915-93-7 3-(2-Methyl-pyridin-4-yl)-3-oxo-2-phenyl-propionitrile 

Relevant academic research and scientific papers

QUINUCLIDINONE ANALOGUES AS ANTICANCER AGENTS

The disclosure includes compounds of Formula (I) and Formula(A) wherein R1, R2, R3, m, n, k, and L are defined herein. Also disclosed are methods for treating a neoplastic disease, autoimmune disease, or an inflammatory disorder with these compounds.

2 - Methyl pyridine -4 - formic acid pyridine ring reduced to piperidine (by machine translation)

The invention discloses a method for reducing a pyridine ring to piperidine in 2-picoline-4-formic acid. The method comprises the step one of preparation of 2-picoline-4-ethyl formate, wherein the initiator 2-picoline-4-formic acid is dissolved into ethyl alcohol solvent, thionyl chloride is dropped into the mixture to carry out esterification reaction to obtain esterification product mixing liquid, and after-treatment is carried out on the esterification product mixing liquid to obtain the 2-picoline-4-ethyl formate; the step two of reduction reaction, wherein the 2-picoline-4-ethyl formate generated through the reaction in the former step is pressurized under the effect of a catalyst, hydrogen is introduced into the 2-picoline-4-ethyl formate to carry out reduction reaction to obtain a reduction product mixing liquid, the addition quantity of the catalyst is 10%-20% of the content of the initiator, and the catalyst is a mixture of palladium carbon and rhodium carbon; the step three of after-treatment, wherein the reaction product mixing liquid reacted in the step two is treated to obtain a 2-picoline-4-ethyl formate product. The new method for producing the 2-picoline-4-ethyl formate has the advantages of being high in efficiency, high in reaction speed and simple in process.

Synthesis of Functionalized Pyridines via a Regioselective Oxazoline Promoted C-H Amidation Reaction

The first Rh-catalyzed C-H amidation of pyridines is reported. The incorporation of a substituent at the C2 position both is crucial to the success of this transformation and provides considerable scope for further elaboration of the resulting products. Among these compounds, 2-chloropyridines allow access to a selection of intermediates including a versatile azaquinazoline scaffold.