25700-14-5

Basic information

• Product Name: 2-IMIDAZOL-1-YL-PYRIDINE
• Synonyms: AKOS BBS-00000367;2-IMIDAZOL-1-YL-PYRIDINE;Pyridine,2-(1H-iMidazol-1-yl)-;2-(1H-Imidazol-1-yl)pyridine;N-(2-Pyridyl)imidazole
• CAS NO: 25700-14-5
• Molecular Formula: C₈H₇N₃
• Molecular Weight: 145.16
• Mol File: 25700-14-5.mol

Chemical Properties

• Melting Point: 62-63℃
• Boiling Point: 310.6 °C at 760 mmHg
• Flash Point: 141.6 °C
• Appearance: /
• Density: 1.16 g/cm³
• PKA: 4.55±0.10(Predicted)
• CAS DataBase Reference: 2-IMIDAZOL-1-YL-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-IMIDAZOL-1-YL-PYRIDINE(25700-14-5)
• EPA Substance Registry System: 2-IMIDAZOL-1-YL-PYRIDINE(25700-14-5)

Safety Data

• Hazardous Substances Data: 25700-14-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
2-IMIDAZOL-1-YL-PYRIDINE is used as a key building block in the pharmaceutical industry for the synthesis of various drugs. Its unique structure allows it to be a versatile component in the development of new medicinal compounds with potential therapeutic applications.
Used in Agrochemical Development:
In the agrochemical industry, 2-IMIDAZOL-1-YL-PYRIDINE serves as a crucial intermediate in the creation of novel agrochemicals. Its incorporation into these products can lead to the development of more effective and targeted pesticides or other agricultural chemicals.
Used in Organic Chemistry Research:
2-IMIDAZOL-1-YL-PYRIDINE is utilized as a valuable compound in organic chemistry research. Its distinctive structure makes it an interesting subject for studies aimed at understanding its reactivity, synthesis pathways, and potential to form new types of organic compounds.
Used in Drug Discovery:
Due to its potential biological activities, 2-IMIDAZOL-1-YL-PYRIDINE is explored in drug discovery processes. Its interaction with enzymes and receptors suggests that it could be a promising candidate for the development of new drugs targeting specific biological pathways.
Overall, 2-IMIDAZOL-1-YL-PYRIDINE's diverse applications across different industries highlight its significance in modern chemical research and development. Its unique structure and potential uses make it an important compound for future innovations in pharmaceuticals, agrochemicals, and organic chemistry.

Upstream product

• 110-86-1 pyridine 
• 18156-74-6 1-(Trimethylsilyl)imidazole 
• 288-32-4 1H-imidazole 
• 107264-09-5 1-fluoro-pyridinium tetrafluoroborate 
• 694-59-7 pyridine N-oxide 
• 2232-08-8 N-tosylimidazole 
• 67-56-1 methanol 
• 12354-84-6 bis[dichloro(pentamethylcyclopentadienyl)iridium(III)] 

Downstream Products

• 1434057-47-2 3-phenyl-1-(pyridin-2-yl)-1H-imidazol-3-ium tetrafluoroborate 
• 1443119-31-0 1-benzyl-3-(pyridin-2-yl)imidazolium bromide 

Relevant articles and documents

Alcohol-Induced C?N Bond Cleavage of Cyclometalated N-Heterocyclic Carbene Ligands with a Methylene-Linked Pendant Imidazolium Ring

Reaction of the pentamethylcyclopentadienyl rhodium iodide dimer [Cp*RhI2]2with 1,1′-diphenyl-3,3′-methylenediimidazolium diiodide in non-alcohol solvents, in the presence of base, led to the formation of bis-carbene complex [Cp*Rh(bis-NHC)I]I (bis-NHC=1,1′-diphenyl-4,4′-methylenediimidazoline-5,5′-diylidene). In contrast, when employing alcohols as the solvent in the same reaction, cleavage of a methylene C?N bond is observed, affording ether-functionalized (cyclometalated) carbene ligands coordinated to the metal center and the concomitant formation of complexes with a coordinated imidazole ligand. Studies employing other 1,1′-diimidazolium salts indicate that the cyclometalation step is a prerequisite for the activation/scission of the C?N bond and, based on additional experimental data, a SN2 mechanism for the reaction is tentatively proposed.

One-step conversion of azine N -oxides to α-1,2,4-triazolo-, 1,2,3-triazolo, imidazolo-, and pyrazoloheteroarenes

Pyridine, quinoline, isoquinoline, azaindole, and pyrimidine N-oxides were converted to their α-triazole and α-diazole derivatives by treatment with the corresponding p-toluenesulfonylazoles and Hunigs base at elevated temperatures.

A highly regioselective reaction of N-fluoropyridinium salts with stabilized sulfur, oxygen, and nitrogen nucleophiles: A convenient route to 2-substituted pyridines

2-Substituted pyridines are efficiently obtained by the reactions of N- fluoropyridinium tetrafluoroborate or triflate with anions derived from benzenethiols, phenols, azoles, cyanamide, and with azide anion. The results are consistent with a nucleophile addition at the position 2 of the N- fluoropyridinium cation as the major reaction pathway.