25743-12-8

Basic information

• Product Name: NH-(PEG2-OH)2
• Synonyms: NH-(PEG2-OH)2;NH-bis(PEG2-OH)
• CAS NO: 25743-12-8
• Molecular Formula: C₁₂H₂₇NO₆
• Molecular Weight: 281.34588
• Mol File: 25743-12-8.mol

Chemical Properties

• Boiling Point: 409.1±40.0 °C(Predicted)
• Appearance: /
• Density: 1.099±0.06 g/cm3(Predicted)
• PKA: 14.06±0.10(Predicted)
• CAS DataBase Reference: NH-(PEG2-OH)2(CAS DataBase Reference)
• NIST Chemistry Reference: NH-(PEG2-OH)2(25743-12-8)
• EPA Substance Registry System: NH-(PEG2-OH)2(25743-12-8)

Safety Data

• Hazardous Substances Data: 25743-12-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
NH-(PEG2-OH)2 is used as a conjugation agent for enhancing the solubility, stability, and bioavailability of drug molecules. By attaching PEG chains to therapeutic agents, it can improve their pharmacokinetic properties, reduce immunogenicity, and prolong their circulation time in the body. This is particularly useful for the development of more effective and safer drugs.
Used in Diagnostic Industry:
In the field of diagnostics, NH-(PEG2-OH)2 is used as a labeling agent for the modification of imaging probes and contrast agents. The PEGylation of these agents can improve their stability, reduce non-specific binding, and enhance their targeting capabilities, leading to better diagnostic outcomes.
Used in Biomedical Research:
NH-(PEG2-OH)2 is employed as a versatile building block in the synthesis of various bioconjugates for research purposes. It can be used to create conjugates with a wide range of biomolecules, including peptides, proteins, nucleic acids, and small molecules, enabling the study of their interactions, properties, and functions in a controlled manner.
Used in Drug Delivery Systems:
NH-(PEG2-OH)2 is used as a component in the design and development of drug delivery systems, such as nanoparticles, liposomes, and hydrogels. The PEGylation of these systems can improve their stability, biocompatibility, and targeting capabilities, leading to more effective and safer therapeutic applications.

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Relevant articles and documents

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Regulated assemblies from vesicles to micelles based on 1,3-alternate oxacalix[2]arene[2]triazine amphiphilic molecules were reported. The vesicular entities were responsive to anions and followed the selectivity in the order NO3- >

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Different types of water-soluble ligands were synthesized and their capability was evaluated by solvent extraction studies to complex trivalent actinides and suppress their extraction by a strong lipophilic ligand, such as TODGA. The back extraction efficiency of hydrophilic diglycolamide (DGA) derivatives with a varying number of ethylene glycol groups, or containing sodium acetate moieties on the amidic nitrogen shows a decrease in back-extraction efficiency with increasing number of ethylene glycol units on the amidic nitrogen at various pH values of the aqueous phase. Among the PS donating ligands only the ligand with a malonamide backbone exhibits a high reverse extraction efficiency, although, with no selectivity for americium. Within the water-soluble tripodal ligands, i.e. the amide derivatives of nitrilotriacid with N,N-dimethyl and N,N-bis(hydroxyethyl) moieties, the first one shows a pronounced selectivity for Am(iii) over Eu(iii), with a maximum separation factor of 11.1, while the latter one more efficiently complexes the radionuclides in the aqueous phase with a maximum separation factor of 5. Isothermal microcalorimetry experiments of the complexation of Eu(iii) by a selected series of ligands confirm the observed trend in the back extraction properties.

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The reaction of N,N-di(oligooxyethylene)amines with arenesulfonyl chloride in the presence of alkali metal hydroxide was investigated.It was found that the monoarenesulfonates of N,N-di(oligooxyethylene)amines were first formed as intermediates, and their subsequent intramolecular cyclization gave N-unsubstituted monoaza crown ethers rather selectively.