6338-55-2Relevant articles and documents
Cofactor-free detection of phosphatidylserine with cyclic peptides mimicking lactadherin
Zheng, Hong,Wang, Fang,Wang, Qin,Gao, Jianmin
, p. 15280 - 15283 (2011)
Cyclic peptides (cLacs) are designed to mimic the natural phosphatidylserine (PS) binding protein lactadherin. Unlike annexin V or its small molecule mimics, the cLac peptides selectively target PS-presenting membranes with no need for metal cofactors. We further show that a fluorophore-labeled cLac effectively stains early apoptotic cells. The small size and facile conjugation with a variety of imaging tracers make the cLac design promising for imaging cell death in vitro as well as in living organisms.
MERTK DEGRADERS AND USES THEREOF
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Paragraph 00974, (2020/01/31)
The present invention provides compounds, compositions thereof, and methods of using the same.
Multiple arms polymerization target anticancer conjugate
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, (2019/04/05)
Disclosed is a multi-arm targeting drug conjugate modified by a water-soluble polymer; the drug conjugate has the structural formula of (III). In formula (III), R is an organic core, POLY is a polymer, L is a multivalent linker, T is a targeting molecule, D is a camptothecin-based drug, and q is any integer between 3 and 8. The drug conjugate may improve the poor water solubility, high toxicity and low bioavailability of camptothecin-based drugs.
