258497-21-1

Basic information

• Product Name: 6-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID
• Synonyms: 6-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLATE;6-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID;6-N-BOC-AMINOPICOLINIC ACID;2-PYRIDINECARBOXYLIC ACID, 6-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-;6-((tert-Butoxycarbonyl)aMino)picolinic acid;6-[[(1,1-dimethylethoxy)carbonyl]amino]-2-Pyridinecarboxylic acid;6-BOC-AMINO-PYRIDINE-2-CARBOXYLIC ACID;6-[(tert-Butoxycarbonyl)amino]-2-pyridinecarboxylic acid
• CAS NO: 258497-21-1
• Molecular Formula: C₁₁H₁₄N₂O₄
• Molecular Weight: 238.24
• Product Categories: pharmacetical
• Mol File: 258497-21-1.mol

Chemical Properties

• Boiling Point: 360.385 °C at 760 mmHg
• Flash Point: 171.755 °C
• Appearance: /
• Density: 1.293 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: 2-8°C
• PKA: 1.07±0.50(Predicted)
• CAS DataBase Reference: 6-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID(258497-21-1)
• EPA Substance Registry System: 6-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID(258497-21-1)

Safety Data

• Hazardous Substances Data: 258497-21-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with enhanced therapeutic properties. Its unique structure allows for the creation of compounds with specific biological activities, addressing unmet medical needs.
Used in Agrochemical Industry:
In the agrochemical sector, 6-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID is utilized as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its incorporation into these products aids in the design of more effective and targeted agrochemicals, promoting sustainable agricultural practices.
Used in Medicinal Chemistry Research:
6-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID is employed as a research chemical in medicinal chemistry, facilitating the exploration of its potential applications in drug discovery. Its unique properties make it an attractive candidate for studying the structure-activity relationships of various biologically active compounds.
Used in Drug Discovery:
As a component in drug discovery processes, 6-TERT-BUTOXYCARBONYLAMINO-PYRIDINE-2-CARBOXYLIC ACID is used to identify and optimize lead compounds with potential therapeutic applications. Its versatility in chemical modifications enables the development of novel drug candidates with improved pharmacological profiles.

InChI:InChI=1/C11H14N2O4/c1-11(2,3)17-10(16)13-8-6-4-5-7(12-8)9(14)15/h4-6H,1-3H3,(H,14,15)(H,12,13,16)

Upstream product

• 499-83-2 Pyridine-2,6-dicarboxylic acid 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 69142-64-9 ethyl 6-aminopicolinate 
• 408368-74-1 tert-butyl 6-{[(4-nitrobenzyl)amino]carbonyl}-2-pyridinylcarbamate 
• 258497-27-7 (6-tert-butoxycarbonylamino-pyridin-2-yl)-trityloxyimino-acetic acid methyl ester 
• 258497-18-6 (Z)-2-(2-tert-butoxycarbonylaminopyrid-6-yl)-2-(triphenylmethoxyimino)acetic acid 
• 258497-48-2 methyl 6-tert-butoxycarbonylamino-2-pyridinecarboxylate 
• 259533-24-9 3-[4-(2-tert-butoxycarbonylamino-ethylsulfanylmethyl)-[1,2,3]thiadiazol-5-ylsulfanyl]-7-[2-(6-tert-butoxycarbonylamino-pyridin-2-yl)-2-trityloxyimino-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 

Relevant articles and documents

7-acylamino-3-heteroarylthio-3-cephem carboxylic acid antibiotics and prodrugs thereof

The present invention relates to a cephem prodrug having formula III or formula IV: or a pharmaceutically acceptable salt thereof, wherein R′1is selected from the group consisting of hydrogen and —C(O)CH(NH2)CH3and R′2is selected from the group consisting of hydrogen and an acyl group that is cleaved by an enzyme found in mammals, with the proviso that, when either R′1or R′2is hydrogen, the other is not. A, B, L, G, E, and J are each independently nitrogen or carbon such that the respective rings are selected from the group consisting of provided that the group —CH2—S—CH2CH2NHR′2is attached only to a carbon atom of said heterocyclic group, and Q is selected from the group consisting of nitrogen and —CX, wherein X is selected from the group consisting of hydrogen and chlorine.

DRUG DISCHARGE PUMP INHIBITORS

A medicament for preventive and/or therapeutic treatment of a microbial infection having an activity of eliminating resistance of a microorganism with acquired resistance to an antimicrobial agent, which comprises as an active ingredient a compound represented by the following general formula (I), a physiologically acceptable salt thereof, or a hydrate thereof: wherein R1 and R2 independently represent hydrogen atom, a halogen atom, carboxyl group and the like; J1 represents a 5- or 6-membered heteroaromatic ring; W1 represents -CH=CH-, -C≡C-, -CH2CH2- and the like; A1 represents phenylene group, pyridinediyl group, furandiyl group and the like; G1 represents oxygen atom, carbonyl group, ethynyl group and the like; p represents an integer of from 0 to 3; G2 represents phenylene group, furandiyl group, tetrahydrofurandiyl group and the like; G3 represents -CH2- or single bond; m and n represent an integer of 0 or 1; and Q1 represents an acidic group.

New anti-MRSA cephalosporins with a basic aminopyridine at the C-7 position

Incorporation of a basic aminopyridine into the C-7 position of 3-(amine-substituted arylthio)-3-norcephalosporins, as in 3, afforded high potency against MRSA and acceptable solubility for intravenous administration.

Cephalosporin antibiotics

The present invention includes novel compounds of formula where G, H, J, L and M are carbon or nitrogen, R99 is selected from the group consisting of sulfur, SO, SO2, NH, N-alkyl, oxygen, C 3BOND C (cis or trans), and C 3BOND C, and R12 is NR13R14, The invention also includes the pharmacologically acceptable salts which exhibit antibiotic activity against a wide spectrum of organisms including organisms which are resistant to beta -lactam antibiotics and are useful as antibacterial agents. The invention also relates to novel intermediates useful for making the novel compounds of the present invention and to novel methods for producing the novel compounds and intermediate compounds.

Cephalosporin antibiotics

The present invention includes novel compounds of formula where A, B, D, and E are selected from the group consisting of carbon, nitrogen and sulfur, R99 is selected from the group consisting of sulfur, SO, S02, NH, N-alkyl, oxygen, C=C (cis or trans), and C 3BOND C, and R12 is NR13R14, The invention also includes the pharmacologically acceptable salts which exhibit antibiotic activity against a wide spectrum of organisms including organisms which are resistant to beta -lactam antibiotics and are useful as antibacterial agents. The invention also relates to novel intermediates useful for making the novel compounds of the present invention and to novel methods for producing the novel compounds and intermediate compounds.