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5-Bromo-2-methylbenzyl alcohol is a chemical compound characterized by the molecular formula C8H9BrO. It is a white solid derivative of benzyl alcohol, featuring a bromine atom and a methyl group attached to the benzene ring. 5-Bromo-2-methylbenzyl alcohol is recognized for its versatility and reactivity in organic chemistry, making it a valuable reagent in various synthesis processes.

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  • 258886-04-3 Structure
  • Basic information

    1. Product Name: 5-Bromo-2-methylbenzyl alcohol
    2. Synonyms: 5-Bromo-2-methylbenzyl alcohol;(5-bromo-2-methylphenyl)methanol;5-bromo-2-methylbenzenemethanol;BENZENEMETHANOL, 5-BROMO-2-METHYL-
    3. CAS NO:258886-04-3
    4. Molecular Formula: C8H9BrO
    5. Molecular Weight: 201.06046
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 258886-04-3.mol
  • Chemical Properties

    1. Melting Point: 60 °C
    2. Boiling Point: 289.6±25.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.481±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. PKA: 14.29±0.10(Predicted)
    10. CAS DataBase Reference: 5-Bromo-2-methylbenzyl alcohol(CAS DataBase Reference)
    11. NIST Chemistry Reference: 5-Bromo-2-methylbenzyl alcohol(258886-04-3)
    12. EPA Substance Registry System: 5-Bromo-2-methylbenzyl alcohol(258886-04-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 258886-04-3(Hazardous Substances Data)

258886-04-3 Usage

Uses

Used in Pharmaceutical Synthesis:
5-Bromo-2-methylbenzyl alcohol is utilized as a building block in the synthesis of pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique structure allows for the creation of a diverse range of medicinal compounds with potential health benefits.
Used in Agrochemical Production:
In the agrochemical industry, 5-Bromo-2-methylbenzyl alcohol serves as a key intermediate for the production of various agrochemicals. Its incorporation into these products helps enhance crop protection and management strategies, supporting agricultural productivity.
Used in Material Science:
5-Bromo-2-methylbenzyl alcohol is employed in the development of new materials, leveraging its chemical properties to engineer innovative substances with unique characteristics. This application extends its utility beyond traditional chemical synthesis, broadening its impact on material development.
Used as a Precursor for Specialty Chemicals:
As a precursor, 5-Bromo-2-methylbenzyl alcohol is instrumental in the preparation of other specialty chemicals. Its role in this capacity highlights its importance in the synthesis of complex and high-value chemical products, further expanding its applications across various industries.

Check Digit Verification of cas no

The CAS Registry Mumber 258886-04-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,5,8,8,8 and 6 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 258886-04:
(8*2)+(7*5)+(6*8)+(5*8)+(4*8)+(3*6)+(2*0)+(1*4)=193
193 % 10 = 3
So 258886-04-3 is a valid CAS Registry Number.

258886-04-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name (5-bromo-2-methylphenyl)methanol

1.2 Other means of identification

Product number -
Other names 5-bromo-2-methylbenzenemethanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:258886-04-3 SDS

258886-04-3Relevant articles and documents

INHIBITORS OF KEAP1-Nrf2 PROTEIN-PROTEIN INTERACTION

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Paragraph 1663-1664, (2020/03/01)

Sultam compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with the KEAP1-Nrf2 interaction, such as inflammatory bowel disease, including Crohn's disease and ulcerative colitis.

HYDROXYPYRIDOXAZEPINES AS NRF2 ACTIVATORS

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Page/Page column 86, (2020/08/28)

The present invention relates hydroxypyridoxazepine compounds, methods of making them, pharmaceutical compositions containing them and their use as Nrf2 activators. In particular, the invention relates to compounds of Formula (I), and pharmaceutically acc

SGLTS INHIBITOR AND APPLICATION THEREOF

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Paragraph 0117-0120, (2020/11/30)

A compound as an SGLT1/SGLT2 dual inhibitor, and an application thereof in the preparation of a drug as the SGLT1/SGLT2 dual inhibitor. The compound is a compound represented by formula (I), an isomer thereof, or a pharmaceutically acceptable salt thereof

Catalyst system for producing polyethylene copolymers in a high temperature solution polymerization process

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, (2019/06/10)

Catalyst system for producing ethylene copolymers in a high temperature solution process, the catalyst system comprising (i) a metallocene complex of formula (I) wherein M is Hf X is a sigma ligand, L is a bridge of the formula —SiR82—, wherein each R8 is independently a C1-C20-hydrocarbyl, tri(C1-C20-alkyl)silyl, C6-C20-aryl, C7-C20-arylalkyl or C7-C20-alkylaryl n is 0, 1 or 2 R1 and R1′ are the same or can be different and can be a linear or branched C1-C6-alkyl group, R2 and R2′ are the same or are different and are a CH2—R9 group, with R9 being H or linear or branched C1-C6-alkyl group R5 and R5′ are the same or are different and can be H or a linear or branched C1-C6-alkyl group or a OR group, wherein R is a C1-C6-alkyl group R6 and R6′ are the same or are different and can be H or a C(R10)3 group, with R10 being the same or different and R10 can be H or a linear or branched C1-C6-alkyl group or R5 and R6 and/or R5′ and R6′ taken together form an unsubstituted 4-7 membered ring condensed to the benzene ring of the indenyl moiety, and R7 and R7′ can be the same or are different and can be H or a linear or branched C1-C6-alkyl group (ii) an aluminoxane cocatalyst and/or (iii) a boron containing cocatalyst and (iv) optionally an aluminum alkyl compound.

Method for preparing alcoholic compound from anilino lithium compound as catalyst

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Paragraph 0030, (2019/03/06)

The invention relates to an application of an anilino lithium compound, in particular to a method for preparing an alcoholic compound from the anilino lithium compound as a catalyst. The catalyst, borane and carboxylic acid are stirred and mixed uniformly, subjected to a reaction and exposed to air to terminate the reaction, a reacted liquid is subjected to reduced-pressure treatment for solvent removal, silica gel and methanol are added, and the alcoholic compound is obtained by hydrolysis. The anilino lithium compound can perform high-activity catalysis on the reaction between carboxylic acid and borane at room temperature, dose of the catalyst is only 0.8mol% of the mole ratio of carboxylic acid, compared with the conventional catalysis system, the commercial reagent anilino lithium compound is used, reaction conditions are mild, and yield of borate with different substituents under limit conditions can reach 90% or higher.

Based on n-butyl aromatic carboxylic acid preparation of alcohol compound

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Paragraph 0030, (2019/03/29)

The present invention relates to n-butyl application, in particular to based on n-butyl aromatic carboxylic acid preparation of alcohol compound, the catalyst sequentially, borane and carboxylic acid uniformly stirred and mixed, exposed to the air after the reaction terminated in the reaction, the reaction solution under reduced pressure to remove the solvent, then adding silica gel methanol hydrolyzed to obtain the alcohol compound. The invention discloses a butyl lithium can be high activity under the room temperature condition of catalytic carboxylic acid and borane borohydride reaction, the catalyst levels are only the molar amount of carboxylic acid 0.5 μM %, compared with the prior catalytic system, using the commercial reagent is BuLi, mild reaction conditions, in under a limited condition of different substituents of the yield of the ester can reach 90% or more.

A is by aromatic carboxylic acid non-catalytic reaction of alcohol compound (by machine translation)

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Paragraph 0028, (2019/04/17)

The present invention discloses a non-catalytic reaction of the aromatic carboxylic acid preparation of alcohol compound. In an inert gas atmosphere, after dehydration and deoxidation treatment of the reaction bottle [...] borane and carboxylic acid stirring and mixing, reaction 6 - 12 hours to obtain borate, further hydrolyzed into alcohol; said carboxylic acid is benzoic acid, 4 - bromobenzoic acid, 4 - fluoro benzoic acid, 1 - naphthoic acid, 2 - methoxybenzene formic acid and the like. The invention for the first time in the absence of catalyst under the conditions of high-efficiently using carboxylic acid with borane generating borohydrite reaction, carbonyl compound with borane generating borohydrite reaction preparation borate, further hydrolysis alcohol, provides new programme. (by machine translation)

BISARYL AMIDES AS NRF2 REGULATORS

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Page/Page column 323, (2018/09/11)

The present invention relates to bisaryl amide analogs, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the invention relates to bisaryl heterocycles of Formula (I).

OXOPYRIDINE DERIVATIVES USEFUL AS AMINOCARBOXYMUCONATE SEMIALDEHYDE DECARBOXYLASE (ACMSD) INHIBITORS

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Page/Page column 81; 82, (2018/07/29)

The present invention is related to a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of aminocarboxymuconate semialdehyde decarboxylase (ACMSD).

3-OXO-1,4-DIAZEPINYLE COMPOUNDS AS NRF2 ACTIVATORS

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Page/Page column 92, (2018/07/05)

The present invention relates to bisaryl lactam compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the compounds of this invention include a compound of Formula (I):

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