1544673-46-2

Basic information

• Product Name: [2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol
• Synonyms: [2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol
• CAS NO: 1544673-46-2
• Molecular Weight: 248.13
• Mol File: 1544673-46-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: [2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol(CAS DataBase Reference)
• NIST Chemistry Reference: [2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol(1544673-46-2)
• EPA Substance Registry System: [2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol(1544673-46-2)

Safety Data

• Hazardous Substances Data: 1544673-46-2(Hazardous Substances Data)

Usage

General Description

The chemical [2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol is a compound with a complex structure that contains a phenyl group and a boron-containing ring. It is classified as a boronic acid derivative and is commonly used in organic synthesis and medicinal chemistry as a reagent for Suzuki-Miyaura cross-coupling reactions. The compound is known for its ability to form stable complexes with a wide range of substrates and has been studied for its potential applications in the development of new pharmaceuticals and materials. Additionally, it has been investigated for its potential use as a fluorescent probe in biological imaging and sensing applications. Overall, [2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol is a versatile chemical with diverse applications in various fields of chemistry and biology.

Upstream product

• 89-95-2 2-methyl-benzyl alcohol 
• 79669-49-1 5-bromo-2-methylbenzoic acid 
• 258886-04-3 (5-bromo-2-methylphenyl)methanol 
• 73183-34-3 bis(pinacol)diborane 
• 79669-50-4 methyl 2-methyl-5-bromobenzoate 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 1352132-34-3 2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 
• 1106869-99-1 (3-formyl-4-methylphenyl)boronic acid 

Downstream Products

• 1544673-61-1 2-[2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]isoindoline-1,3-dione 
• 1544673-80-4 [2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanamine 

Relevant articles and documents

HYDROXYPYRIDOXAZEPINES AS NRF2 ACTIVATORS

The present invention relates hydroxypyridoxazepine compounds, methods of making them, pharmaceutical compositions containing them and their use as Nrf2 activators. In particular, the invention relates to compounds of Formula (I), and pharmaceutically acc

Para-Selective C-H Borylation of Common Arene Building Blocks Enabled by Ion-Pairing with a Bulky Countercation

The selective functionalization of C-H bonds at the arene para position is highly challenging using transition metal catalysis. Iridium-catalyzed borylation has emerged as a leading technique for arene functionalization, but there are only a handful of strategies for para-selective borylation, which operate on specific substrate classes and use bespoke ligands or catalysts. We describe a remarkably general protocol which results in para-selectivity on some of the most common arene building blocks (anilines, benzylamines, phenols, benzyl alcohols) and uses standard borylation ligands. Our strategy hinges upon the facile conversion of the substrates into sulfate or sulfamate salts, wherein the anionic arene component is paired with a tetrabutylammonium cation. We hypothesize that the bulk of this cation disfavors meta-C-H borylation, thereby promoting the challenging para-selective reaction.

NRF2 REGULATORS

Provided are aryl analogs，pharmaceutical compositions containing them and their use as NRF2 regulators.