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4-(1-cyano-1-methyl-ethyl)-benzonitrile is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 260981-45-1 Structure
  • Basic information

    1. Product Name: 4-(1-cyano-1-methyl-ethyl)-benzonitrile
    2. Synonyms: 4-(1-cyano-1-methyl-ethyl)-benzonitrile
    3. CAS NO:260981-45-1
    4. Molecular Formula:
    5. Molecular Weight: 170.214
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 260981-45-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-(1-cyano-1-methyl-ethyl)-benzonitrile(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-(1-cyano-1-methyl-ethyl)-benzonitrile(260981-45-1)
    11. EPA Substance Registry System: 4-(1-cyano-1-methyl-ethyl)-benzonitrile(260981-45-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 260981-45-1(Hazardous Substances Data)

260981-45-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 260981-45-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,0,9,8 and 1 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 260981-45:
(8*2)+(7*6)+(6*0)+(5*9)+(4*8)+(3*1)+(2*4)+(1*5)=151
151 % 10 = 1
So 260981-45-1 is a valid CAS Registry Number.

260981-45-1Relevant articles and documents

1,4-Dicarbofunctionalization of 4-Fluoroaryl Grignard and Lithium Reagents with Disubstituted Malononitriles

Malapit, Christian A.,Luvaga, Irungu K.,Reeves, Jonathan T.,Volchkov, Ivan,Busacca, Carl A.,Howell, Amy R.,Senanayake, Chris H.

, p. 4993 - 4997 (2017/05/12)

An efficient one-pot 1,4-dicarbofunctionalization of 4-fluoroaryl Grignard or lithium reagents with 2,2-disubstituted malononitriles is described. The reaction proceeds by sequential transnitrilation and SNAr reactions. Commercial Grignard solutions, Grignard reagents prepared in situ by halogen/magnesium exchange with i-PrMgCl, or aryllithium reagents prepared in situ by bromine/lithium exchange with n-BuLi are compatible with the reaction conditions. Moreover, 2,2-disubstituted malononitriles of diverse structures are accommodated. The reaction provides a unique approach to 1,4-dicarbofunctionalization of activated arenes in a tandem, one-pot transformation.

Overcoming challenges in the palladium-catalyzed synthesis of electron deficient ortho-substituted aryl acetonitriles

Brannock, Molly C.,Behof, William J.,Morrison, Gregory,Gorman, Christopher B.

scheme or table, p. 2661 - 2666 (2011/05/15)

Highly electron deficient monoaryl, di-aryl and bis-diaryl acetonitriles were effectively synthesized using either a nucleophilic aromatic substitution (NAS) or a palladium-mediated coupling pathway. Synthesis of di-aryl acetonitriles most conveniently pr

TRPV1 ANTAGONISTS

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Page/Page column 26, (2009/05/28)

Compounds of formula (I) wherein R1, R2, R4, and W are defined in the description are TRPV 1 antagonists with CNS penetration. Compositions comprising such compounds and methods for treating conditions and disorders using

BENZIMIDAZOLE DERIVATIVES USEFUL IN TREATMENT OF VALLINOID RECE TOR TRPVL RELATED DISORDERS

-

Page/Page column 68-69, (2008/06/13)

The claimed invention provides benzimidazole derivatives antagonists of VRl, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds of Formula I may be used in the treatment of osteoarthritis,

P(i-BuNCH2CH2)3N: An efficient ligand for the direct α-arylation of nitriles with aryl bromides

You, Jingsong,Verkade, John G.

, p. 8003 - 8007 (2007/10/03)

A new catalyst system for the synthesis of α-aryl-substituted nitriles is reported. The bicyclic triaminophosphine P(i-BuNCH 2CH2)3N (1b) serves as an efficient and versatile ligand for the palladium-catalyzed direct α-arylation of nitriles with aryl bromides. Using ligand 1b, ethyl cyanoacetate and primary as well as secondary nitriles are efficiently coupled with a wide variety of aryl bromides possessing electron-rich, electron-poor, electron-neutral, and sterically hindered groups.

FUROISOQUINOLINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND USE THEREOF

-

, (2008/06/13)

A compound having a partial structure represented by Formula: or a salt thereof has an excellent phosphodiesterase (PDE) IV-inhibiting effect, and is useful as a prophylactic or therapeutic agent against inflammatory diseases, for example, bronchial asthma, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, autoimmune disease, diabetes and the like.

A General Method for the Direct α-Arylation of Nitriles with Aryl Chlorides

You, Jingsong,Verkade, John G.

, p. 5051 - 5053 (2007/10/03)

The long-standing challenge of developing a general method for the title methodology is met for a broad range of aryl chlorides through the use of bicyclic P(iBuNCH2CH2)3N (1) as a bulky electron-rich ligand for palladium (see scheme, dba = dibenzylideneacetone).

Synthesis, characterization, and reactivity of arylpalladium cyanoalkyl complexes: Selection of catalysts for the α-arylation of nitriles

Culkin, Darcy A.,Hartwig, John F.

, p. 9330 - 9331 (2007/10/03)

A new coupling process, the palladium-catalyzed α-arylation of nitriles, was developed by exploring the structure and reactivity of arylpalladium cyanoalkyl complexes. Complexes of 1,2-bis(diphenylphosphino)benzene (DPPBz), 1,1′-bis(di-i-propylphosphino)ferrocene (DiPrPF), racemic-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (BINAP), and diphenylethylphosphine (PPh2Et) were prepared. Coordination to palladium through the α-carbon was observed for DPPBz-ligated complexes and for complexes of primary and benzylic nitrile anions. However, the anion of isobutyronitrile was coordinated to palladium through the cyano-nitrogen when the complex was ligated by DiPrPF. The isobutyronitrile anion displaced a phosphine ligand to form a C,N-bridged dimer when generated from PPh2Et-ligated palladium. These results suggest that the nitrile anion preferentially coordinates to palladium through the carbon atom in the absence of steric effects. Thermolysis of the arylpalladium cyanoalkyl complexes led to reductive elimination that formed α-aryl nitriles. The high yields and short reaction times observed for BINAP-ligated complexes suggested that BINAP-ligated palladium catalysts might be appropriate for the arylation of nitriles. Initial results on a palladium-catalyzed process for the direct coupling of aryl bromides and primary, benzylic, and secondary nitrile anions to form α-aryl nitriles in good yields are reported. Copyright

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