26103-48-0

Basic information

• Product Name: 4-(Pyridin-3-ylsulphonyl)morpholine
• Synonyms: 4-(Pyridin-3-ylsulphonyl)morpholine;4-(Pyridin-3-ylsulphonyl)morpholine 98%;4-(3-Pyridinylsulfonyl)morpholine;4-(Pyridin-3-ylsulfonyl)morpholine;3-(MORPHOLINOSULFONYL)PYRIDINE;4-(Pyridin-3-ylsulphonyl)morpholine98%
• CAS NO: 26103-48-0
• Molecular Formula: C9H12N2O3S
• Molecular Weight: 228.26818
• Product Categories: blocks;Pyridines;Sulfonamides
• Mol File: 26103-48-0.mol

Chemical Properties

• Melting Point: 120 °C
• Boiling Point: 404 °C at 760 mmHg
• Flash Point: 198.1 °C
• Appearance: /
• Density: 1.35 g/cm³
• Vapor Pressure: 9.77E-07mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.89±0.11(Predicted)
• CAS DataBase Reference: 4-(Pyridin-3-ylsulphonyl)morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Pyridin-3-ylsulphonyl)morpholine(26103-48-0)
• EPA Substance Registry System: 4-(Pyridin-3-ylsulphonyl)morpholine(26103-48-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 26103-48-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
4-(Pyridin-3-ylsulphonyl)morpholine is used as a reagent in pharmaceutical research for its potential medicinal properties. It is being explored as an enzyme inhibitor, which could have implications for the development of treatments targeting specific diseases.
Used in Organic Synthesis:
In the field of organic synthesis, 4-(Pyridin-3-ylsulphonyl)morpholine is utilized as a building block for the synthesis of other complex molecules. Its unique structure allows it to be a key component in creating new compounds with various applications.
Used in Disease Treatment:
4-(Pyridin-3-ylsulphonyl)morpholine is being investigated for its potential use in the treatment of various diseases. Its enzyme inhibitory activity suggests that it could play a role in managing or treating conditions related to enzyme dysregulation.
Used in Chemical Research:
Due to its unique structure and potential for versatile applications, 4-(Pyridin-3-ylsulphonyl)morpholine is of interest to researchers in the field of chemistry. It provides opportunities for studying new reactions and exploring its behavior in different chemical environments.

InChI:InChI=1/C9H12N2O3S/c12-15(13,9-2-1-3-10-8-9)11-4-6-14-7-5-11/h1-3,8H,4-7H2

Upstream product

• 110-91-8 morpholine 
• 16133-25-8 Pyridine-3-sulfonyl chloride 
• 636-73-7 3-pyridinesulfonic acid 
• 93056-12-3 S-(3-pyridyl) benzothioate 
• 1120-90-7 3-iodopyridine 
• 5765-65-1 4-(benzoyloxy)morpholine 

Downstream Products

• 88184-95-6 [3-(Morpholine-4-sulfonyl)-pyridin-4-yl]-diphenyl-methanol 

Relevant articles and documents

Copper-catalyzed electrophilic amination of sodium sulfinates at room temperature

By using O-benzoyl hydroxylamines as amine sources, the first convenient copper-catalyzed electrophilic amination of sodium sulfinates has been realized. Even with 2 mol% catalyst loading, the protocol provided an efficient and straightforward synthesis of a broad range of functional sulfonamides under ambient reaction conditions without an additional base and ligand. Based on the control experiments, a plausible mechanism was proposed.

A general and mild two-step procedure for the synthesis of aryl and heteroaryl sulfonamides from the corresponding iodides

A mild two-step preparation of aryl and heteroaryl sulfonyl chlorides and sulfonamides from their corresponding iodides is developed. Acid labile functionalities are shown to be stable under both the copper-catalysed coupling and the subsequent oxidative chlorination.

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