Controlled Reduction of Carboxamides to Alcohols or Amines by Zinc Hydrides
New protocols for controlled reduction of carboxamides to either alcohols or amines were established using a combination of sodium hydride (NaH) and zinc halides (ZnX2). Use of a different halide on ZnX2 dictates the selectivity, wherein the NaH-ZnI2 system delivers alcohols and NaH-ZnCl2 gives amines. Extensive mechanistic studies by experimental and theoretical approaches imply that polymeric zinc hydride (ZnH2)∞ is responsible for alcohol formation, whereas dimeric zinc chloride hydride (H?Zn?Cl)2 is the key species for the production of amines.
Mild microwave-assisted synthesis of dipyrromethanes and their analogues
The Mannich reaction between pyrroles or indoles and Eschenmoser's salt (dimethylmethylideneammonium iodide) forms N,N-dimethylamino-methylated derivatives in good to excellent yields. The reaction is highly regioselective, and for pyrroles both 2-and 3-s
Xiong, Ruisheng,Borbas, K. Eszter
supporting information
p. 484 - 488
(2015/04/14)
Rhodium(II) catalyzed intramolecular insertion of carbenoids derived from 2-pyrrolyl and 3-indolyl α-diazo-β-ketoesters and α-diazoketones
α-Diazo-β-ketoesters and α-diazoketones derived from 2-pyrrolylacetic, 2-pyrrolylpropionic, 3-indolylacetic and 3-indolylpropionic acids afforded carbenoid derived cyclization products on treatment with catalytic rhodium(II) acetate.
Cuevas-Ya?ez, Erick,Muchowski, Joseph M.,Cruz-Almanza, Raymundo
p. 1505 - 1511
(2007/10/03)
1,3,6-trihydro-6-aza-3-oxapentalen-2-one derivatives for the treatment of neoplasia
1,3,6-Trihydro-6-Aza-3-Oxapentalen-2-One Derivatives for inhibiting neoplastic conditions.
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(2008/06/13)
Photocyclization strategy for the synthesis of antitumor agent CC-1065: Synthesis of dideoxy PDE-I and PDE-II. Synthesis of thiophene and furan analogues of dideoxy PDE-I and PDE-II
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Rawal,Jones,Cava
p. 19 - 28
(2007/10/02)
Photocyclization of Pyrrole Analogues of Stilbene: an Expedient Approach to Antitumor Agent CC-1065
Described are the preliminary results of a photochemical cyclization based approach to CC-1065; readily available heterocycles are converted into pyrrole analogues of stilbene which are cyclized to give the tricyclic ring structure necessary for CC-1065 a
Rawal, Viresh H.,Cava, Michael P.
p. 1526 - 1527
(2007/10/02)
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