Synthesis of mono- and diaza-'pyridones' via stille coupling of alkoxystannanes
Various alkoxy-substituted heterocyclic stannanes provide access to the corresponding substituted 'pyridone' moieties via Stille cross-coupling. Both pyridyl and a series of diazinyl stannanes are prepared, and options for unmasking (via demethylation or debenzylation) of the pyridone unit are evaluated. Georg Thieme Verlag Stuttgart. New York.
Smith, Charlotte L.,Hirschh?user, Christoph,Malcolm, Georgia K.,Nasrallah, Daniel J.,Gallagher, Timothy
p. 1904 - 1908
(2014/08/18)
PIPERDINE COMPOUNDS AND USES THEREOF-911
Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.
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Page/Page column 83
(2009/01/24)
First study of syntheses and reactivity of Grignard compounds in the diazine series. Diazines. Part 27
A preparation of Grignard derivatives of diazines is described using a halogen magnesium exchange reaction. This convenient method allows the functionalization of these rings at 0°C or even room temperature.
Leprêtre,Turck,Plé,Knochel,Quéguiner
p. 265 - 273
(2007/10/03)
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