26368-94-5Relevant articles and documents
3,10-di-p-chlorophenyl-6,12-diazatetrahomocubane compound and synthesis method, application and pharmaceutical composition thereof
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Paragraph 0031, (2020/01/03)
The invention discloses a 3,10-di-p-chlorophenyl-6,12-diazatetrahomocubane compound and a synthesis method, application in anti-inflammatory activity and pharmaceutical composition thereof, and relates to the field of compound synthesis. The compound has
3,10-di-p-methoxyphenyl-6,12-diazatetrakishomocubane compound as well as a synthetic method, application and pharmaceutical composition thereof
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Paragraph 0035, (2020/01/03)
The invention discloses a 3,10-di-p-methoxyphenyl-6,12-diazatetrakishomocubane compound as well as a synthetic method, application and pharmaceutical composition thereof. The compound has a structurerepresented by a formula I shown in the specification, c
Di-aza-tetra-homocubane compound and preparation method and application thereof
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Paragraph 0030; 0033-0035, (2019/10/05)
The invention discloses a di-aza-tetra-homocubane compound and a preparation method and application thereof in a neuroprotective drug especially for the cerebral apoplexy. Pharmacological experiments show that the compound exhibits neuroprotective activit
Straightforward Regeneration of Reduced Flavin Adenine Dinucleotide Required for Enzymatic Tryptophan Halogenation
Ismail, Mohamed,Schroeder, Lea,Frese, Marcel,Kottke, Tilman,Hollmann, Frank,Paul, Caroline E.,Sewald, Norbert
, p. 1389 - 1395 (2019/02/10)
Flavin-dependent halogenases are known to regioselectively introduce halide substituents into aromatic moieties, for example, the indole ring of tryptophan. The process requires halide salts and oxygen instead of molecular halogen in the chemical halogena
Tandem dinucleophilic cyclization of cyclohexane-1,3-diones with pyridinium salts
Kiamehr, Mostafa,Moghaddam, Firouz Matloubi,Mkrtchyan, Satenik,Semeniuchenko, Volodymyr,Supe, Linda,Villinger, Alexander,Langer, Peter,Laroshenko, Viktor O.
supporting information, p. 1119 - 1126 (2013/07/19)
The cyclization of cyclohexane-1,3-diones with various substituted pyridinium salts afforded functionalized 8-oxa-10-aza-tricyclo[7.3.1.0 2,7]trideca-2(7),11-dienes. The reaction proceeds by regioselective attack of the central carbon atom of t
Pyridinium salts - Versatile reagents for the regioselective synthesis of functionalized thiazocino[2,3-b]indoles by tandem dinucleophilic reactions of thiooxindoles
Kiamehr, Mostafa,Gormay, Pavel V.,Villinger, Alexander,Langer, Peter,Iaroshenko, Viktor O.,Moghaddam, Firouz Matloubi,Semeniuchenko, Volodymyr
supporting information, p. 9685 - 9693,9 (2020/08/20)
The reaction of thiooxindoles with various 2- and 3-substituted pyridinium salts afforded a variety of functionalized thiazocinoindoles. The products have been prepared in good to excellent yields by regioselective dinucleophilic C/S-cyclocondensation of
Azole additions upon azinium salts
Lavilla, Rodolfo,Gotsens, Teresa,Guerrero, Marta,Masdeu, Carme,Santano, M. Carmen,Minguillon, Cristina,Bosch, Joan
, p. 13959 - 13968 (2007/10/03)
The additions of pyrrole and indole upon N-acetyl- and N-alkylpyridinium, quinolinium or isoquinolinium sails are reported. The resulting dihydroazines are either isolated or oxidised to the more stable aromatic compounds. The use of a two-phase system wa
Approaches to Chemically Modified Enzymes As Synthetic Catalysts
Aitken, David J.,Alijah, Renate,Onyiriuka, Samuel O.,Suckling, Colin J.,Wood, Hamish C. S.,Zhu, Limin
, p. 597 - 608 (2007/10/02)
Attempts to introduce new catalytic activities of potential use in synthetic transformations into enzyme active sites are described.Substitution of the naturally occurring zinc in carboxypeptidase A by several metals known to catalyse hydrogenation was investigated; a new protein characterised as a rhodium carboxypeptidase was isolated but it failed to show activity as a hydrogenation catalyst for the reduction of a series of dehydroamino acid amides.Horse liver alcohol dehydrogenase was investigated for its potential to act as an oxygen transferase via Lewis acid catalysis.A series of cyclohexenyl and phenylribosides together with new alkenyl(arenyl)oxymethylenoxyethanols was prepared for evaluation as substrates; in the course of this study, novel neighbouring group participation by the oxygen atom of a chloromethyl ether was observed.Although the binding of potential oxygen acceptors (alkenes and aromatic compounds) and oxygen donors (hydrogen peroxide and alkyl hydroperoxides) was demonstrated, oxygen transfer did not occur with the combinations investigated.In contrast to the failure of the above metalloenzymes to catalyse new reactions, papain modified at the active site sulfhydryl group by thiazolium salts and pyridinium salts was shown to exhibit reactions characteristic of the covalently attached cofactor.Thus the thiazolopapains acted as decarboxylation catalysts for pyruvate and the pyridinopapains could be reduced to dihydropyridines which reduced electrophilic carbonyl substrates with small enantiomeric excess.
Structure Sensitivity of the Marcus λ for Hydride Transfer between NAD+ Analogues
Kreevoy, Maurice M.,Ostovic, Drazen,Lee, In-Sook Han,Binder, David A.,King, Gary W.
, p. 524 - 530 (2007/10/02)
Thirty-five rate constants, kij, for transfer of hydride between various pyridinium, quinilinium, acridinium, and phenantridinium ions spanning a range of over 10E11 in their equilibrium constants Kij and over 10E6 in kij