Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens
Potent nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase have been derived from a file compound high throughput screening hit. Optimized compounds show excellent antibacterial activity against staphylococcal and enterococcal pathogen
Jarvest, Richard L.,Hibbs, Martin J.,Jaworski, Deborah D.,O'Hanlon, Peter J.,Pope, Andrew J.,Rittenhouse, Stephen,Sheppard, Robert J.,Slater-Radosti, Courtney,Worby, Angela,Berge, John M.,Berry, Valerie,Boyd, Helen F.,Brown, Murray J.,Elder, John S.,Forrest, Andrew K.,Fosberry, Andrew P.,Gentry, Daniel R.
p. 1959 - 1962
(2007/10/03)
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