26414-86-8

Basic information

• Product Name: 2-Pyridinethioacetamide
• Synonyms: 2-Pyridinethioacetamide;GYKI-43023;2-(2-Pyridyl)thioacetaMide, 97%
• CAS NO: 26414-86-8
• Molecular Formula: C₇H₈N₂S
• Molecular Weight: 152.22
• Mol File: 26414-86-8.mol

Chemical Properties

• Melting Point: 88-89 °C
• Boiling Point: 292.2°C at 760 mmHg
• Flash Point: 130.5°C
• Appearance: /
• Density: 1.226g/cm³
• Vapor Pressure: 0.00186mmHg at 25°C
• Refractive Index: 1.639
• PKA: 12.87±0.29(Predicted)
• CAS DataBase Reference: 2-Pyridinethioacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinethioacetamide(26414-86-8)
• EPA Substance Registry System: 2-Pyridinethioacetamide(26414-86-8)

Safety Data

• Hazardous Substances Data: 26414-86-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H8N2S/c8-7(10)5-6-3-1-2-4-9-6/h1-4H,5H2,(H2,8,10)

Upstream product

• 2739-97-1 pyridine-2-acetonitrile 
• 5451-39-8 2-(pyridine-2-yl)acetamide 
• 2739-98-2 ethyl 2-(pyridinyl-2)acetate 
• 1221640-05-6 C₇H₈N₂ 
• 54765-14-9 2‐(pyridin‐2‐yl)acetaldehyde 
• 6959-47-3 2-chloromethylpyridine hydrochloride 

Relevant articles and documents

Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels

An initial SAR study on a series of apamin-displacing 2-aminothiazole KCa2 channel blockers is described. Potent inhibitors such as N-(4-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (13) are disclosed, and for select members of the series, the relationship between the observed activity in a thallium flux, a binding and a whole-cell electrophysiology assay is presented.

A new thionation reagent: Preparation of primary thioamides from nitriles

Phosphorus decasulfide reacts with sodium sulfide (1:1 ratio) in tetrahydrofuran at 25°C to afford an in situ reagent 1C (5 eq.) that rapidly converts nitriles into thioamides at 20°C.

Metal-free, one-pot oxidative conversion of aldehydes to primary thioamides in aqueous media

One-pot tandem reactions of a variety of aldehydes with aqueous ammonia, molecular iodine, and O,O-diethyl dithiophosphoric acid readily afford the corresponding primary thioamides. This is an inexpensive, practical, and metal-free way of accessing various thioamides from aldehydes in aqueous media. The pure products are obtained simply by filtration followed by successive washing with aqueous sodium thiosulfate and water. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]