26414-86-8Relevant articles and documents
Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels
Gentles, Robert G.,Grant-Young, Katherine,Hu, Shuanghua,Huang, Yazhong,Poss, Michael A.,Andres, Charles,Fiedler, Tracey,Knox, Ronald,Lodge, Nicholas,Weaver, C. David,Harden, David G.
, p. 5316 - 5319 (2008)
An initial SAR study on a series of apamin-displacing 2-aminothiazole KCa2 channel blockers is described. Potent inhibitors such as N-(4-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (13) are disclosed, and for select members of the series, the relationship between the observed activity in a thallium flux, a binding and a whole-cell electrophysiology assay is presented.
A new thionation reagent: Preparation of primary thioamides from nitriles
Brillon
, p. 1397 - 1401 (1992)
Phosphorus decasulfide reacts with sodium sulfide (1:1 ratio) in tetrahydrofuran at 25°C to afford an in situ reagent 1C (5 eq.) that rapidly converts nitriles into thioamides at 20°C.
Metal-free, one-pot oxidative conversion of aldehydes to primary thioamides in aqueous media
Yadav, Arvind K.,Srivastava, Vishnu P.,Yadav, Lal Dhar S.
, p. 408 - 416 (2014/01/06)
One-pot tandem reactions of a variety of aldehydes with aqueous ammonia, molecular iodine, and O,O-diethyl dithiophosphoric acid readily afford the corresponding primary thioamides. This is an inexpensive, practical, and metal-free way of accessing various thioamides from aldehydes in aqueous media. The pure products are obtained simply by filtration followed by successive washing with aqueous sodium thiosulfate and water. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]