5451-39-8

Basic information

• Product Name: PYRIDINE-2-ACETAMIDE
• Synonyms: PYRIDINE-2-ACETAMIDE;Piperidine-2-acetamide;Pyridine-2-acetamide,98%;2-PYRIDINEACETAMIDE, 98%;2-(2-pyridyl)acetamide;2-pyridin-2-ylacetamide;2-pyridin-2-ylethanamide
• CAS NO: 5451-39-8
• Molecular Formula: C₇H₈N₂O
• Molecular Weight: 136.15
• Mol File: 5451-39-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 118-120°C
• Boiling Point: 332.8°Cat760mmHg
• Flash Point: 155.1°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 0.000142mmHg at 25°C
• Refractive Index: 1.557
• PKA: 15.87±0.40(Predicted)
• CAS DataBase Reference: PYRIDINE-2-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PYRIDINE-2-ACETAMIDE(5451-39-8)
• EPA Substance Registry System: PYRIDINE-2-ACETAMIDE(5451-39-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 5451-39-8(Hazardous Substances Data)

Usage

Uses

2-Pyridineacetamide is used as pharmaceutical intermediate.

InChI:InChI=1/C7H8N2O/c8-7(10)5-6-3-1-2-4-9-6/h1-4H,5H2,(H2,8,10)

Upstream product

• 100-69-6 2-vinylpyridine 
• 7732-18-5 water 
• 64-17-5 ethanol 
• 107920-27-4 benzoyloxy-[2]pyridyl-acetic acid amide 
• 110-86-1 pyridine 
• 7664-41-7 ammonia 
• 13115-43-0 2-pyridineacetic acid 
• 2739-97-1 pyridine-2-acetonitrile 
• 2739-98-2 ethyl 2-(pyridinyl-2)acetate 
• 1658-42-0 methyl 2-pyridylacetate 

Downstream Products

• 2739-97-1 pyridine-2-acetonitrile 
• 26414-86-8 2-(pyridin-2-yl)-thioacetamide 
• 2739-98-2 ethyl 2-(pyridinyl-2)acetate 
• 85274-59-5 N-phenyl-2-(pyridin-2-yl)acetamide 
• 1307474-73-2 N-(4-(2-hydroxyethyl)phenyl)-2-(pyridin-2-yl)acetamide 

Relevant articles and documents

Nitrile Hydration Reaction Using Copper Iodide/Cesium Carbonate/DBU in Nitromethane-Water

The catalytic nitrile hydration (amide formation) in a copper iodide/cesium carbonate/1,8-diazabicyclo[5.4.0]undec-7-ene/nitromethane-water system is described. The protocol is robust and reliable; it can be applied to a broad range of substrates with high chemoselectivity.

Chemistry by nanocatalysis: First example of a solid-supported RAPTA complex for organic reactions in aqueous medium

A ruthenium-arene-PTA (RAPTA) complex has been supported for the first time on an inorganic solid, that is, silica-coated ferrite nanoparticles. The resulting magnetic material proved to be a general, very efficient and easily reusable catalyst for three synthetically useful organic transformations; selective nitrile hydration, redox isomerization of allylic alcohols, and heteroannulation of (Z)-enynols. The use of low metal concentration, environmentally friendly water as a reaction medium, with no use at all of organic solvent during or after the reactions, and microwaves as an alternative energy source renders the synthetic processes reported herein "truly" green and sustainable. RAPTA's delight: A nano-RAPTA complex supported on silica-coated ferrite nanoparticles proved to be a general, very efficient and easily reusable catalyst for three synthetically useful organic transformations; selective nitrile hydration, redox isomerization of allylic alcohols, and heteroannulation of (Z)-enynols. The use of low metal concentrations, water as a reaction medium, and microwaves as an energy source renders these processes green and sustainable.

Hydrolysis of nitrile in presence of NaY zeolite under microwave irradiation

The hydrolysis of nitriles in presence of NaY zeolite under microwave irradiations gives corresponding amide in high yield in few minutes.