5451-39-8Relevant academic research and scientific papers
Nitrile Hydration Reaction Using Copper Iodide/Cesium Carbonate/DBU in Nitromethane-Water
Kuwabara, Jun,Sawada, Yoshiharu,Yoshimatsu, Mitsuhiro
supporting information, p. 2061 - 2065 (2018/09/14)
The catalytic nitrile hydration (amide formation) in a copper iodide/cesium carbonate/1,8-diazabicyclo[5.4.0]undec-7-ene/nitromethane-water system is described. The protocol is robust and reliable; it can be applied to a broad range of substrates with high chemoselectivity.
Hydrolysis of nitrile in presence of different zeolite catalysts under microwave IR-radiation
Singh, Ravinder,Kumar, Ramesh
experimental part, p. 1403 - 1404 (2012/09/22)
The hydrolysis of nitriles in presence of different zeolite catalysts under microwave irradiations gives corresponding amide in high yield in few minutes.
Chemistry by nanocatalysis: First example of a solid-supported RAPTA complex for organic reactions in aqueous medium
García-Garrido, Sergio E.,Francos, Javier,Cadierno, Victorio,Basset, Jean-Marie,Polshettiwar, Vivek
experimental part, p. 104 - 111 (2012/01/06)
A ruthenium-arene-PTA (RAPTA) complex has been supported for the first time on an inorganic solid, that is, silica-coated ferrite nanoparticles. The resulting magnetic material proved to be a general, very efficient and easily reusable catalyst for three synthetically useful organic transformations; selective nitrile hydration, redox isomerization of allylic alcohols, and heteroannulation of (Z)-enynols. The use of low metal concentration, environmentally friendly water as a reaction medium, with no use at all of organic solvent during or after the reactions, and microwaves as an alternative energy source renders the synthetic processes reported herein "truly" green and sustainable. RAPTA's delight: A nano-RAPTA complex supported on silica-coated ferrite nanoparticles proved to be a general, very efficient and easily reusable catalyst for three synthetically useful organic transformations; selective nitrile hydration, redox isomerization of allylic alcohols, and heteroannulation of (Z)-enynols. The use of low metal concentrations, water as a reaction medium, and microwaves as an energy source renders these processes green and sustainable.
Arene-ruthenium(II) complexes containing inexpensive tris(dimethylamino) phosphine: Highly efficient catalysts for the selective hydration of nitriles into amides
Garcia-Alvarez, Rocio,Diez, Josefina,Crochet, Pascale,Cadierno, Victorio
experimental part, p. 5442 - 5451 (2011/12/13)
The catalytic hydration of nitriles into amides, in water under neutral conditions, has been studied using a series of arene-ruthenium(II) derivatives containing the commercially available and inexpensive ligand tris(dimethylamino)phosphine. Among them, best results were obtained with the complex [RuCl2(η6-C6Me6) {P(NMe2)3}], which selectively provided the desired amides in excellent yields and short times (TOF values up to 11 400 h-1). The process was operative with both aromatic, heteroaromatic, aliphatic, and α,β-unsaturated organonitriles and showed a high functional group tolerance. The stability of [RuCl2(η6-C 6Me6){P(NMe2)3}] in water was evaluated, observing its progressive decomposition into the less-active dimethylamine-ruthenium(II) complex [RuCl2(η6-C 6Me6)(NHMe2)] by hydrolysis of the coordinated P(NMe2)3 ligand. The X-ray crystal structure determination of the toluene complex [RuCl2(η6-C6H 5Me){P(NMe2)3}] is also included.
Hydrolysis of nitrile in presence of NaY zeolite under microwave irradiation
Singh, Ravinder,Kumar, Ramesh
experimental part, p. 317 - 320 (2012/02/04)
The hydrolysis of nitriles in presence of NaY zeolite under microwave irradiations gives corresponding amide in high yield in few minutes.
Aryl-indolyl maleimides as inhibitors of CaMKIIδ. Part 1: SAR of the aryl region
Levy, Daniel E.,Wang, Dan-Xiong,Lu, Qing,Chen, Zheng,Perumattam, John,Xu, Yong-jin,Liclican, Albert,Higaki, Jeffrey,Dong, Hanmin,Laney, Maureen,Mavunkel, Babu,Dugar, Sundeep
, p. 2390 - 2394 (2008/09/21)
A family of aryl-substituted maleimides was prepared and studied for their activity against calmodulin dependant kinase. Inhibitory activities against the enzyme ranged from 34 nM to >20 μM and were dependant upon both the nature of the aryl group and the hydrogen bond donating potential of the maleimide ring. Key interactions with the kinase ATP site and hinge region were found to be consistent with homology modeling predictions.
NaY zeolite: A useful catalyst for nitrile hydrolysis
Milli?, Dragana R.,Opsenica, Dejan M.,Adnadevi?, Borivoje,?olaja, Bogdan A.
, p. 118 - 126 (2007/10/03)
The NaY zeolite catalysed hydrolysis of nitriles to primary amides is reported. It is found that aryl nitriles with strong electron-withdrawing substituents and cyanopyridines are readily hydrolysed in the water suspension, while aliphatic nitriles do not react.
A MILD EFFICIENT PROCEDURE FOR THE CONVERSION OF CARBOXYLIC ACID ESTERS TO PRIMARY AMIDES USING FORMAMIDE/METHANOLIC SODIUM METHOXIDE
Jagdmann, G. Erik,Munson, H. Randall,Gero, Thomas W.
, p. 1203 - 1208 (2007/10/02)
An improved method for the preparation of primary carboxylic acid amides from the corresponding esters is described.This reaction was easily followed by GLC and was usually complete in less than one hour.
11a-Methano-TXA compounds
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, (2008/06/13)
The present invention provides novel 11a-methano-TXA compounds and intermediates and processs for their preparation. Further provided are methods for using these novel TXA analogs as inhibitors of thromboxane synthetase, rendering these analogs useful for a variety of pharmacological purposes. These pharmacological uses include anti-inflammatory, anti-thromobitc, and anti-asthma indications.
