26454-85-3

Basic information

• Product Name: 2-AMINO-5-(4-CHLORO-PHENYL)-FURAN-3-CARBONITRILE
• Synonyms: 2-AMINO-5-(4-CHLORO-PHENYL)-FURAN-3-CARBONITRILE
• CAS NO: 26454-85-3
• Molecular Formula: C₁₁H₇ClN₂O
• Molecular Weight: 218.63908
• Mol File: 26454-85-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-AMINO-5-(4-CHLORO-PHENYL)-FURAN-3-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-(4-CHLORO-PHENYL)-FURAN-3-CARBONITRILE(26454-85-3)
• EPA Substance Registry System: 2-AMINO-5-(4-CHLORO-PHENYL)-FURAN-3-CARBONITRILE(26454-85-3)

Safety Data

• Hazardous Substances Data: 26454-85-3(Hazardous Substances Data)

Usage

Molecular Structure

Contains a furan ring with a carbonitrile group (\text-C \equiv \textN) attached at the 3-position, and a 4-chloro-phenyl group (\text-C6\textH4\textCl) attached at the 5-position.

Biological Activities

Potential applications in pharmaceutical and agrochemical industries due to its biological activities.

Synthetic Applications

Acts as a building block for the synthesis of various organic compounds.

Pharmacological Properties

May exhibit antifungal, antibacterial, or antitumor activities.

Functional Groups

Contains an amino group (\text-NH2) at the 2-position, a carbonitrile group (\text-C \equiv \textN) at the 3-position, and a 4-chloro-phenyl group (\text-C6\textH4\textCl) at the 5-position, making it versatile for organic synthesis and drug discovery.

Value in Research

Its unique structure and functional groups make it a valuable intermediate in organic synthesis and drug discovery research.

Upstream product

• 26454-81-9 2-(2-(4-chlorophenyl)-2-oxoethyl)malononitrile 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 877-37-2 2-bromo-1-(4-chlorophenyl)-1-propanone 
• 109-77-3 malononitrile 
• 15424-14-3 N-phenylbenzohydrazonoyl chloride 
• 25939-01-9 p-toluoyl chloride phenylhydrazone 
• 36590-52-0 N-phenyl-p-chlorobenzohydrazonoyl chloride 
• 25939-02-0 4-fluoro-N'-phenylbenzohydrazonoyl chloride 

Downstream Products

• 744255-24-1 6-(4-chloro-phenyl)-furo[2,3-d]pyrimidin-4-ylamine 
• 1253900-76-3 N-[5-(4-chlorophenyl)-3-cyano-2-furanyl]benzamide 
• 1347725-57-8 2-(4-chlorophenyl)-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-amine 
• 1347725-60-3 2-(4-chlorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]furo[3,2-e]pyridin-4-amine 

Relevant articles and documents

Copper-Catalyzed Tandem Dehydrocyanation and [3+2] Cyclo-addition Reactions of Phenacylmalononitriles: Regioselective Synthesis of Functionalized 4-Benzoyl-5-cyanopyrazoles under Mild Conditions

A novel copper-catalyzed [3+2] cycloaddition reaction with concomitant in situ generation of benzoylacrylonitriles and nitrile imines from phenacylmalononitriles and hydrazonoyl chlorides, respectively, is reported. The reaction was performed using copper(I) chloride as catalyst and N-methylimidazole as a clean complexing agent/weak base to afford the functionalized 4-benzoyl-5-cyanopyrazoles in moderate to good yields and excellent regioselectivity under ambient conditions. This method provides rapid access to a wide range of highly functionalized 4-benzoyl-5-cyanopyrazoles.

One-pot synthesis of substituted 2-amino-3-furonitriles

Solvent-free reaction of substituted a-haloketones with malononitrile in the presence of diethylamine provides an efficient one-pot synthesis of 2-amino-5-aryl (alkyl)-3-furonitriles in high yield.

COMPOUND FOR INHIBITING TYROSINE KINASE ACTIVITY OF DDR2 PROTEIN

A new furopyrimidine compound, their pharmaceutically acceptable salt, and a tyrosine kinase activity inhibitor. The furopyrimidine compound is a compound defined by chemical formula 1, 2, 3 or 4, on their precursor, and can exist as a form of free base or in an acid-addition salt. Since the furopyrimidine compound has an effect of inhibiting activity of DDR2 tyrosine kinase, it can be used in treating illnesses caused by the DDR2 tyrosine kinase activity such as hepatocirrhosis, rheumatoid arthritis or cancer.

4-Acylamino-6-arylfuro[2,3-d]pyrimidines: Potent and selective glycogen synthase kinase-3 inhibitors

Modeling studies of a furo[2,3-d]pyrimidine GSK-3 hit compound 1 superimposed onto the X-ray crystal structure of a legacy pyrazolo[3,4-c] pyridazine GSK-3 inhibitor 2 led to the identification of 4-acylamino-6- arylfuro[2,3-d]pyrimidine template 3. Synth

New Syntheses of Pyrazolopyrimidine, Pyrazolopyridazine, Isoindolinedione and Pyrazole Derivatives

Phenacylmalononitriles 2 react with hydrazines, acetic-hydrochloric acid and with diazotised primary aromatic amines to afford phenacylpyrazole (5a,b), aminofurans (6a,b) and aminopyrazole derivatives (3a,d) respectively.The synthesised derivatives (3d,6a