264600-81-9Relevant articles and documents
HETEROCYCLYLAMINOMETHYLOXAZOLIDINONES AS ANTIBACTERIALS
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Page/Page column 38, (2010/01/31)
Compounds of formula (I) or a pharmaceutically-acceptable salt, or an in-vivo hydrolysable ester thereof, wherein, for example,HET is an optionally substituted C-linked 5-membered heteroaryl ring containing 2 to 4 heteroatoms independently selected from N
Unusually low barrier to carbamate C-N rotation
Deetz, Martin J.,Forbes, Christopher C.,Jonas, Marco,Malerich, Jeremiah P.,Smith, Bradley D.,Wiest, Olaf
, p. 3949 - 3952 (2007/10/03)
The barrier for rotation about an N-alkylcarbamate C(carbonyl)-N bond is around 16 kcal/mol. In the case of an N-phenylcarbamate, the rotational barrier is lowered to 12.5 kcal/mol, but with N-(2-pyrimidyl)carbamates the barriers are so low (9 kcal/mol)