- GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE
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Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.
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- METHOD FOR PRODUCING DIOL
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PROBLEM TO BE SOLVED: To provide a method for producing a diol having two methylol groups at one carbon atom on an alicyclic skeleton, which is inexpensive and generates a small amount of waste. SOLUTION: There is provided a method for producing a diol re
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Paragraph 0049; 0050
(2019/03/08)
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- GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE
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Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.
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- Diverse ring opening of thietanes and other cyclic sulfides: An electrophilic aryne activation approach
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Organosulfides are a common class of structure units in bioactive molecules and functional materials motivating continuous developments of efficient synthetic methods. Herein, we report an electrophilic aryne-activated ring opening protocol of one or two
- Zheng, Tianyu,Tan, Jiajing,Fan, Rong,Su, Shuaisong,Liu, Binbin,Tan, Chen,Xu, Kun
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p. 1303 - 1306
(2018/02/14)
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- TRICYCLIC COMPOUND SERVING AS IMMUNOMODULATOR
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Provided are compounds of formula I and formula II or pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof. The compounds of formula I and formula II or the pharmaceutically acceptable salts of the compounds provide indole 2,3-dioxygenase (IDO) inhibitory activity and are capable of treating IDO-mediated immunosuppressive diseases, such as infectious diseases or cancer.
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- METHOD FOR PRODUCING DIOL
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PROBLEM TO BE SOLVED: To provide a method for producing a diol having an aliphatic ring skeleton in high yield, while avoiding viscosity increase of a reaction system, sudden heat generation and thermal runaway chemical reaction. SOLUTION: There is provid
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Paragraph 0031
(2017/04/07)
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- 1,1-BIS[(ETHENYLOXY)METHYL]CYCLOHEXANE AND METHOD OF PRODUCTION OF SAME
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A novel compound, 1,1-bis[(ethenyloxy)methyl]cyclohexane having the formula (I) and having a low odor, low volatility and low skin irritability, which is useful as a starting material for a polymerization composition having a low toxicity and excellent cu
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Paragraph 0016; 0017
(2013/03/26)
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- BENZISOXAZOLE COMPOUND
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Disclosed is a compound represented by the general formula (I) or a salt thereof: wherein any one of R1, R2 and R3 represents a group represented by the formula: -(CH2)m-NR11R12 (wherein m is 1 or 2; and R11 and R12 independently represent a hydrogen atom or a C1-6 alkyl group or may, together with a nitrogen atom to which R11 and R12 are bound, form a 4- or 5-membered cyclic group); the remaining two or R1, R2 and R3 independently represent a group represented by the formula: -(O)n-R21 (wherein n is 0 or 1; and R21 represents a hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, or the like); and R4 represents a C1-6 alkyl group which may have a substituent or the like.
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Page/Page column 71
(2009/02/10)
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- Laser-Powered Decomposition of Spiroalkanes (n = 2-5)
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The laser heating of spiroalkanes (n=2-5) and of their 1,1,2,2-tetradeuterated isotopomers reveals dissimilar modes of their thermal decomposition.Spiropentane decomposes into ethene and propadiene via two competing routes: the direct cleavage and the more important cleavage via intermediary methylenecyclobutane.Spirohexane decomposes through two important concurrent pathways which are the expulsions of ethene from the three-membered ring and a more feasible expulsion of ethene from the four-membered ring.Spiroheptane and spirooctane decompose by a radical-chain mechanism and afford complex mixtures of products; upon addition of propene both compounds rearrange into two cycloalkanes wherein the larger ring of the spiroalkane is preserved and substituted with ethylidene and a vinyl group.
- Fajgar, Radek,Pola, Josef
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p. 7709 - 7717
(2007/10/02)
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- Preparation of di- and polynitrates by ring-opening nitration of oxetanes by dinitrogen pentoxide (N2O5)
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Ten oxetanes bearing various substituents were reacted with N2O5 in chlorinated hydrocarbon solvents to yield 1,3-dinitrate esters (I) by ring-opening nitration. The yields ranged from 73 to 88% for di-/trinitrates derived from oxetanes unsubstituted in the 2-position, to only 15 to 21% for oxetanes bearing such substituents. Although selective ring cleavage of oxetanes bearing non-hydroxylic substituents (epoxy (oxiranyl), spiro-oxetane and alkene) was not, in general, possible, selective nitration of hydroxyalkyloxetanes was achievable under the conditions employed to yield nitrato-methyloxetanes useful as precursors for energetic polyethers. A semi-quantitative reactivity comparison with representative epoxides indicated that the reactivity of oxetanes towards N2O5 was lower, as expected on account of their lower ring strain.
- Golding,Millar,Paul,Richards
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p. 7051 - 7062
(2007/10/02)
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- Process for producing a deprotected alkoxylated polyol
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An improved process for the hydrolysis and purification of an alkoxylated polyol containing a ketal protective functionality, and which may be employed to prepare reduced calorie esterified alkoxylated polyol fat mimetics useful in cooking and in food compositions, comprises contacting an aqueous mixture of the protected alkoxylated polyol with an acid to hydrolyse and thus deprotect the alkoxylated polyol,adding a base to neutralise the acid and cause the mixture to form a first phase containing the deprotected alkoxylated polyol and a second phase containing predominantly water, and separating the phases. The protected alkoxylated polyol may be formed by alkoxylating a protected polyol. The deprotected alkoxylated polyol may subsequently be esterified.
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- Process for the production of high energy materials
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A process for the production of a high energy nitrate ester involves reacting, in an inert organic solvent, a heterocyclic compound, selected from oxiranes, oxetanes, N-substituted aziridines and N-substituted azetidines, with either N2 O4 or N2 O5, and when the compound is reacted with N2 O4, oxidizing the O- or N-nitrate substituents or substituent in the product to O- or N-nitrate substituent or substituents. The remaining ring carbon atoms on the heterocyclic compound may be substituted or unsubstituted. Preferred substituent groups for the C and/or N ring atoms on the compound include alkyl, cyanoalkyl, haloalkyl, nitroalkyl, and substituted aryl. Several novel nitrate ester are also provided, including nitrated derivatives of polybutadiene, in which between 1% and 25% of the carbon atoms in the polymer are substituted by vicinal nitrate ester (--ONO2) groups.
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