- SAR Exploration of Tight-Binding Inhibitors of Influenza Virus PA Endonuclease
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Significant efforts have been reported on the development of influenza antivirals including inhibitors of the RNA-dependent RNA polymerase PA N-terminal (PAN) endonuclease. Based on recently identified, highly active metal-binding pharmacophore
- Credille, Cy V.,Morrison, Christine N.,Stokes, Ryjul W.,Dick, Benjamin L.,Feng, Yifan,Sun, Jiaxing,Chen, Yao,Cohen, Seth M.
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supporting information
p. 9438 - 9449
(2019/10/28)
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- Design, synthesis, and structure-activity relationships of aminopyridine N-oxides, a novel scaffold for the potent and selective inhibition of p38 mitogen activated protein kinase
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A novel series of aminopyridine N-oxides were designed, synthesized, and tested for their ability to inhibit p38α MAP kinase. Some of these compounds showed a significant reduction in the LPS-induced TNFR production in human whole blood. Structure-activit
- Lumeras, Wenceslao,Caturla, Francisco,Vidal, Laura,Esteve, Cristina,Balagué, Cristina,Orellana, Adelina,Domínguez, María,Roca, Ramón,Huerta, Josep M.,Godessart, Núria,Vidal, Bernat
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experimental part
p. 5531 - 5545
(2010/02/28)
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- HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH
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Provided herein are Heteroaryl Compounds having the following structure: (I) wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
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Page/Page column 145
(2008/12/05)
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- NOVEL COMPOUNDS
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Novel substituted 1,5,7-trisubstituted-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2-(1H)-one compounds and compositions, and their use in therapy as CSBP/RK/p38 kinase inhibitors.
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Page/Page column 180-181
(2010/11/29)
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- NOVEL COMPOUNDS
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Novel substituted l,5,7-trisubstituted-354-dihydro-pyriinido[4,5-(flpyrimidin- 2-(2H)-one compounds and compositions, and their use in therapy as CSBP/RK/p38 kinase inhibitors.
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Page/Page column 200-201
(2008/06/13)
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