7697-28-1Relevant articles and documents
ORGANIC COMPOUNDS
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Page/Page column 53-54, (2011/04/14)
The present invention provides compounds of the following structure; [in-line-formulae]A-L1-B-C-D[/in-line-formulae] that are useful for treating or preventing conditions or disorders associated with DGAT1 activity in animals, particularly humans.
2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION
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, (2008/06/13)
The present invention has its object to provide a 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine derivative represented with the Formula (1) , or the pharmaceutically acceptable salt, which is effective as a therapeutic and prophylactic agent for diabetes, diabetic nephropathy, or glomerulosclerosis.
FUSED TRICYCLIC COMPOUNDS AS INHIBITORS OF TUMOR NECROSIS FACTOR-ALPHA
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Page/Page column 54, (2010/11/30)
Compounds of formula (1): are disclosed, wherein V is CH2; W is S(O)m; m is the integer 0, 1 or 2; U is O, C(O), CR13R14 or NR15; where R13 is H, alkyl; R14 is H, OH, OR13 or OCOR13; R15 is H, alkyl, cycloalkyl, alkenyl, C(O)R13, C(O)OR13 or alkylaminocarbonyl; R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. These compounds are inhibitor of tumor necrosis factor-alpha (TNF- ) and are useful as medicaments for the treatment and prevention of disorders caused by increased TNF- activity, in particular inflammations.
2,3,4,5-TETRAHYDRO-1H-1,5-BENZODIAZEPINE DERIVATIVE AND MEDICINAL COMPOSITION
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Page/Page column 64-65, (2010/11/30)
A 2,3,4,5-tetrahydro-1H-1,5-benzodiazepine derivative represented by the generalformula (1): [Chemical formula 1] (1) or a pharmaceutically acceptable saltthereof. They are useful as a therapeutic/preventive agent for diabetes, diabeticnephropathy, or glomerulosclerosis.
The first regioselective metalation and functionalization of unprotected 4-halobenzoic acids
Gohier, Frederic,Castanet, Anne-Sophie,Mortier, Jacques
, p. 1501 - 1504 (2007/10/03)
(Chemical Equation Presented) By treatment with s-BuLi, s-BuLi/TMEDA, or t-BuLi at ～-78°C, 4-fluoro- and 4-chlorobenzoic acids (1a,b) are metalated preferentially in the position adjacent to the carboxylate. A complete reversal in regioselectivity is observed for 1a when treated with LTMP; a sequential process involving a rapid intraaggregate lithiation through a quasi dianion complex "QUADAC" is postulated to explain the unusual reactivity of Me2S2 and I2.
CONDENSED PYRAZOLE DERIVATIVES, METHOD OF MANUFACTURING THE SAME, AND ANDROGEN INHIBITOR
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, (2008/06/13)
This invention provides a condensed pyrazole derivative of the Formula (1): STR1 (where A denotes CH or N, R 0 and R 3 denote same or different, a hydrogen atom or a lower alkyl group, R 1 and R 2 denote same or different, a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a nitro group or a halogen atom, m denotes 1 or 2, and n denotes 1, 2 or 3, provided that, when n is 2, two R 2 may be connected to each other to form a lower alkylenedioxy group), or its pharmaceutically acceptable salt. This derivative or its salt is excellent in the effect of inhibiting the expression of action of androgen, thereby being excellent in therapeutical effect of benign prostatic hypertrophy, prostatic carcinoma, etc., and has a long lasting of efficacy and high oral absorption.
The Synthesis of Pyridocarbazoles from Diphenylamine Derivatives: Alternative Routes to and Relay Syntheses of Ellipticines and Olivacines
Hall, Robin J.,Marchant, Jeremy,Oliveira-Campos, Ana M. F.,Queiroz, Maria-Joao R. P.,Shannon, Patrick V. R.
, p. 3439 - 3450 (2007/10/02)
Two new synthetic routes to pyridocarbazoles are described.In the first, Goldberg-type coupling of various aryl sulfonamides with aryl bromides in the presence of copper and potassium carbonate gives N,N-diaryl sulfonamides.UV irradiation of these, in ethanol, removes the toluene-p-sulfonyl protecting groups and cyclises the diphenylamine moiety to the corresponding carbazoles.These carbazoles are established intermediates in the synthesis of several ellipticines (5,11-dimethylpyridocarbazoles).In a complementary route, a series of substituted acetanilides are similarly coupled under Goldberg conditions with 2-bromo-5-cyanotoluene to give the corresponding cyanodiphenylamines and diphenylamides.Hydrolysis of the latter gives the diphenylamines which are then oxidatively cyclised to 3-cyano-1-methylcarbazoles.Reduction of the cyanocarbazoles leads to 3-formylcarbazoles which are known intermediates for the synthesis of 5-methylpyridocarbazoles.
Photolyis of 2-Nitrodiphenylmethanes in Isopropanol and Acidified Aqueous Ethanol
Christudhas, M.,Jacob, E. Dominic,Joshua, C. P.
, p. 815 - 817 (2007/10/02)
2-Nitrodiphenylmethane (1a) on irradiation in isopropanol and acidified ethanol yields benzoic acids as the major product. 3-Phenyl-2,1-benzisoxazole (2a) and acridone (3a) are also formed, though in lower yields. 4,4'-Dichloro/bromo-5,5'-dimethyl-2-nitrodiphenylmethanes (1b, c) on similar irradiation yields 4-halo-3-methylbezoic acid (4) as the major product. 5-Methyl-4-halo-3-(4'-halo-3'-methylphenyl)-2,1-benzisoxazole (2b, c) and acridones (3b, c) are also formed.A plausible mechanism for the formation of various products in the photoreactions is discussed.
