26945-63-1

Basic information

• Product Name: 3-Methoxyiminodibenzyl
• Synonyms: 3-Methoxyiminodibenzyl;10,11-Dihydro-3-Methoxy-5H-dibenz[b,f]azepine;3-Methoxy-10,11-dihydro-5H-dibenz[b,f]azepine
• CAS NO: 26945-63-1
• Molecular Formula: C15H17NO
• Molecular Weight: 227.30158
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 26945-63-1.mol

Chemical Properties

• Melting Point: 94 °C
• Boiling Point: 360.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.105±0.06 g/cm3(Predicted)
• Solubility: Dichloromethane
• PKA: 0.51±0.20(Predicted)
• CAS DataBase Reference: 3-Methoxyiminodibenzyl(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Methoxyiminodibenzyl(26945-63-1)
• EPA Substance Registry System: 3-Methoxyiminodibenzyl(26945-63-1)

Safety Data

• Hazardous Substances Data: 26945-63-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Methoxyiminodibenzyl is used as an intermediate for the production of analgesic, antiallergic, and antihistamine agents. Its chemical structure allows for the creation of various drug metabolites that can be utilized in the development of new medications to treat a range of health conditions.
Used in Drug Metabolism Research:
3-Methoxyiminodibenzyl is also used in the study of drug metabolism, helping researchers understand how different substances are processed and broken down within the body. This knowledge can be applied to improve the efficacy and safety of existing medications and guide the development of new drugs.

Upstream product

• 223787-64-2 3-methoxy-10,11-dihydro-5H-dibenzazepine-5-carbaldehyde 
• 57559-52-1 4-methoxy-2-nitrobenzyl bromide 
• 17484-36-5 4-Methyl-3-nitroanisole 
• 223787-47-1 4-(2-(2-bromophenyl)vinyl)-3-nitroanisole 
• 223787-52-8 4-(2-(2-bromophenyl)ethyl)-3-aminoanisole 
• 223787-57-3 N-(2-(2-(2-bromophenyl)ethyl)-5-methoxyphenyl)formamide 
• 223787-44-8 4-methoxy-2-nitrobenzoylphosphonic acid diethyl ester 

Relevant articles and documents

Synthesis of substituted 10,11-dihydro-5H-dibenz[b,f]azepines; key synthons in syntheses of pharmaceutically active compounds

Substituted 10,11-dihydro-5H-dibenz[b,f]azepines are key synthons in the syntheses of a number of pharmaceutically active compounds such as imipramine, chlorimipramine, and desimipramine analogues. A facile synthesis of substituted 10,11-dihydro-5H-dibenz[b,f]azepines is described, starting out from commercially available 2-bromotoluenes or 2-nitrotoluenes. Initial α-bromination with N-bromosuccinimide and subsequent reaction with triethylphosphite afforded the corresponding benzyl phosphonic ester derivatives. After reaction with benzaldehyde derivatives, the expected Horner-Emmons reaction products were obtained. Hydrogenation gave the amino derivatives which were transformed into the corresponding formamides. Under Goldberg conditions [1], the final ring closing step was performed to give the substituted 10,11-dihydro-5H-dibenz[b,f]azepines in 46-75% yield.