223787-44-8

Upstream product

• 22996-23-2 (4-methoxy-2-nitro-phenyl)-methanol 
• 33844-21-2 2-nitro-4-methoxybenzoic acid 
• 17484-36-5 4-Methyl-3-nitroanisole 
• 57559-52-1 4-methoxy-2-nitrobenzyl bromide 
• 122-52-1 triethyl phosphite 

Downstream Products

• 1050513-68-2 5-methoxy-2-(tetrahydro-2H-pyran-4-ylmethyl)aniline 
• 1422192-57-1 1-Boc-3-(4-methoxy-2-nitrobenzylidene)piperidine 
• 1050513-58-0 4-(4-methoxy-2-nitrobenzylidene)tetrahydro-2H-pyran 
• 303040-33-7 (4-methoxy-2-octanoylamino-benzyl)-phosphonic acid diethyl ester 
• 503856-50-6 (2-amino-4-methoxy-benzyl)-phosphonic acid diethyl ester 
• 223787-47-1 4-(2-(2-bromophenyl)vinyl)-3-nitroanisole 
• 223787-57-3 N-(2-(2-(2-bromophenyl)ethyl)-5-methoxyphenyl)formamide 
• 223787-52-8 4-(2-(2-bromophenyl)ethyl)-3-aminoanisole 
• 26945-63-1 3-Methoxy-10,11-dihydro-dibenzazepin 

Relevant academic research and scientific papers

Rh2(II)-catalyzed selective aminomethylene migration from styryl azides

Rh2(II)-Carboxylate complexes were discovered to promote the selective migration of aminomethylenes in β,β-disubstituted styryl azides to form 2,3-disubstituted indoles. Mechanistic data are also presented that suggest that the migration occurs stepwise before diffusion of the iminium ion.

QUINOXALINE COMPOUNDS AND USE THEREOF

The present invention is related to quinoxaline compounds of Formula (I) in particular for the treatment of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.

Discovery of novel phosphonic acid derivatives as new chemical leads for inhibitors of TNF-α production

2-(Acylamino)benzylphosphonic acid 6 derived from an artificial substrate of sphingomyelinase was found to show inhibitory activity of TNF-α production. Structural optimization was started with the chemical modification of 6. The discovery of another chem

Synthesis of substituted 10,11-dihydro-5H-dibenz[b,f]azepines; key synthons in syntheses of pharmaceutically active compounds

Substituted 10,11-dihydro-5H-dibenz[b,f]azepines are key synthons in the syntheses of a number of pharmaceutically active compounds such as imipramine, chlorimipramine, and desimipramine analogues. A facile synthesis of substituted 10,11-dihydro-5H-dibenz[b,f]azepines is described, starting out from commercially available 2-bromotoluenes or 2-nitrotoluenes. Initial α-bromination with N-bromosuccinimide and subsequent reaction with triethylphosphite afforded the corresponding benzyl phosphonic ester derivatives. After reaction with benzaldehyde derivatives, the expected Horner-Emmons reaction products were obtained. Hydrogenation gave the amino derivatives which were transformed into the corresponding formamides. Under Goldberg conditions [1], the final ring closing step was performed to give the substituted 10,11-dihydro-5H-dibenz[b,f]azepines in 46-75% yield.