223787-57-3

Usage

Uses

Used in Pharmaceutical Industry:
N-[2-[2-(2-Bromophenyl)ethyl]-5-methoxyphenyl]formamide is used as an intermediate in the production of substituted azepine derivatives, which are important in the development of pharmaceuticals with potential therapeutic applications.
Used in Chemical Synthesis:
In the field of chemical synthesis, N-[2-[2-(2-Bromophenyl)ethyl]-5-methoxyphenyl]formamide serves as a key component in the synthesis of various organic compounds, contributing to the creation of new materials and products with diverse applications.

Upstream product

• 223787-44-8 4-methoxy-2-nitrobenzoylphosphonic acid diethyl ester 
• 223787-47-1 4-(2-(2-bromophenyl)vinyl)-3-nitroanisole 
• 17484-36-5 4-Methyl-3-nitroanisole 
• 57559-52-1 4-methoxy-2-nitrobenzyl bromide 
• 64-18-6 formic acid 
• 223787-52-8 4-(2-(2-bromophenyl)ethyl)-3-aminoanisole 

Downstream Products

• 26945-63-1 3-Methoxy-10,11-dihydro-dibenzazepin 

Relevant academic research and scientific papers

Synthesis of substituted 10,11-dihydro-5H-dibenz[b,f]azepines; key synthons in syntheses of pharmaceutically active compounds

Substituted 10,11-dihydro-5H-dibenz[b,f]azepines are key synthons in the syntheses of a number of pharmaceutically active compounds such as imipramine, chlorimipramine, and desimipramine analogues. A facile synthesis of substituted 10,11-dihydro-5H-dibenz[b,f]azepines is described, starting out from commercially available 2-bromotoluenes or 2-nitrotoluenes. Initial α-bromination with N-bromosuccinimide and subsequent reaction with triethylphosphite afforded the corresponding benzyl phosphonic ester derivatives. After reaction with benzaldehyde derivatives, the expected Horner-Emmons reaction products were obtained. Hydrogenation gave the amino derivatives which were transformed into the corresponding formamides. Under Goldberg conditions [1], the final ring closing step was performed to give the substituted 10,11-dihydro-5H-dibenz[b,f]azepines in 46-75% yield.