26978-64-3

Basic information

• Product Name: 1-Butanesulfonic acid, 4-hydroxy-
• Synonyms: 1-Butanesulfonic acid, 4-hydroxy-;4-Hydroxybutane-1-sulfonic acid;Nsc 163335;Nsc 71873;Benzenediazonium,2-methoxy-5-methyl-4-[2-(4-methyl-2-nitrophenyl)diazenyl]-;Busulfan Impurity 3
• CAS NO: 26978-64-3
• Molecular Formula: C₄H₁₀O₄S
• Molecular Weight: 154.18
• Mol File: 26978-64-3.mol

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.393g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.74±0.50(Predicted)
• CAS DataBase Reference: 1-Butanesulfonic acid, 4-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Butanesulfonic acid, 4-hydroxy-(26978-64-3)
• EPA Substance Registry System: 1-Butanesulfonic acid, 4-hydroxy-(26978-64-3)

Safety Data

• Hazardous Substances Data: 26978-64-3(Hazardous Substances Data)

Usage

Uses

1. Used in Pharmaceutical Industry:
1-Butanesulfonic acid, 4-hydroxyis used as a buffering agent for the enantiomeric separation of a variety of underivatized anionic and cationic compounds of pharmaceutical interest. This application is particularly important in the development and production of drugs, as it helps to separate and identify the different forms (enantiomers) of a compound, which can have different biological activities and effects.
2. Used in Capillary Electrophoresis:
In the field of analytical chemistry, 1-Butanesulfonic acid, 4-hydroxyis utilized for the enantiomeric separation of pharmaceutical compounds through capillary electrophoresis. This technique is a powerful tool for the separation and analysis of complex mixtures, and the use of HOBt-hydroxide as a chiral selector enhances the resolution and accuracy of the separation process.

Upstream product

• 627-27-0 homoalylic alcohol 
• 6962-92-1 4-Chlorobutyl acetate 
• 31465-25-5 sodium 4-hydroxybutane-1-sulfonate 
• 30453-20-4 4,4'-dithiodibutan-1-ol 
• 1633-83-6 1,4-butane sultone 
• 928-51-8 4-Chloro-1-butanol 

Downstream Products

• 1633-83-6 1,4-butane sultone 
• 55526-95-9 N-(δ-sulfonatobutyl)-2-methyl-benzothiazole 
• 126-33-0 sulfolane 
• 62607-65-2 5-phenylpentane-1-sulfonic acid 

Relevant articles and documents

Design, synthesis, and evaluation of a highly effective and safe perfluoro-alternative with a "weak site": Potassium 1,1,2,2,3,3,4,4-octafluoro-4-(perfluorobutoxy)butane-1-sulfonate

A novel, highly efficient, degradable alternative perfluorinated compound (APFC) with a "weak site"was synthesized using various methods via a common intermediate. The main reactions were oxidation by sulfonyl chloride, chlorination, and electrolytic fluorination. The synthetic strategies were efficient and suitable for industrial production of the APFC at the kilogram scale. The surface tension of the APFC and inhibition of chromium mist by the APFC were assessed. The APFC met the requirements for being produced industrially and also performed excellently, was resistant to degradation, and was shown to be more environmentally friendly than perfluorooctylsulfonic acid. This journal is

Synthesis method of 1,4-butane sultone

The invention relates to a synthesis method of 1,4-butane sultone and belongs to the technical field of compound synthesis. The synthesis method takes tetrahydrofuran and acetylchloride as raw materials and comprises the following steps: A, preparation of butylchloroacetate: placing tetrahydrofuran and zinc powder in a container, cooling to 15 DEG C or lower, beginning to dropwise add acetylchloride, after dropwise adding, heating to 45 DEG C, holding the temperature for 8-10 hours, then heating to 60 DEG C, holding the temperature for 1-2 hour, performing pressure reduction to extract butylchloroacetate, and B, preparation of 1,4-butane sultone: allowing butylchloroacetate, sodium sulfite and water to give a heating reflux reaction for 14-16 hour, performing pressure reduction till a solid is separated out, cooling to 45 DEG C or lower, dropwise adding methanol hydrochloride solution, performing stirring for 1-2 hours, cooling to 4-6 DEG C, performing suction filtration, performing pressure reduction on filtrate to extract methanol, water and acetic acid, then heating to 130 DEG C, performing high vacuum pressure reduction cyclization for 0.5-1 hour, heating to 150 DEG C, and thenperforming high vacuum pressure reduction to extract 1,4-butane sultone. The synthesis method is simple; a reaction process is mild and stable; a prepared target product is high in yield and purity,and very low in water content and acid content.

Preparation method of 1,4-butane sultone

The invention relates to a preparation method of 1,4-butane sultone. The preparation method comprises the following steps: S1, putting 4-chlorobutanol and a sodium sulfite solution into a reaction vessel to be fully mixed, controlling the temperature to be 25-110 DEG C, performing reaction for 4-24h, and then, performing dehydration under reduced pressure for later use; S2, adding concentrated hydrochloric acid to the material subjected to dehydration under reduced pressure to perform acidification, controlling the temperature to be 25-100 DEG C and performing stirring for 1-12h, then performing cooling to room temperature, performing filtration, and concentrating the filtrate to obtain a concentrated solution containing 4-hydroxybutanesulfonate; S3, putting the concentrated solution in the vacuum environment to enable 4-hydroxybutanesulfonate to be subjected to dehydrated closed loop to obtain a crude product containing 1,4-butane sultone; and S4, performing rectifying treatment on the crude product obtained in the S3 to obtain 1,4-butane sultone. The preparation method provided by the invention has the beneficial effects that the process route is short, the dosages of acid and organic solvents are low, the post-treatment is simple, the total yield reaches 85% or above, and the purity of the product can reach 99.9% or above.

1,4-butane sultone and synthesis process thereof

1,4-butane sultone and a synthesis process thereof relate to the field of fine chemical engineering. The synthesis process comprises the steps: performing sulfonation on 3-butylene-1-alcohol or 3-butylene-1-chlorine serving as a raw material and a sulfonating agent under the oxidation-reduction of an initiator; performing acidification after the reaction is finished; performing lactonization by high vacuum dehydration cyclization and azeotropic dehydration cyclization; and finally refining to obtain a 1,4-butane sultone finished product. The synthesis process of the 1,4-butane sultone, provided by the invention, is easily available in raw materials, few in synthesis steps, high in yield, high in product purity and suitable for industrialized production. The invention also provides the 1,4-butane sultone which is prepared by the synthesis process and has high purity.

Oxidative Cleavage and Cyclization of Disulfide Carboxylic Acids and Alcohols by Aqueous Iodine: A Facile Route to Five-Membered Ring Sultines

The kinetics and mechanism of the oxidative cleavage by aqueous iodine of disulfide carboxylic acids and alcohols are presented.There is evidence for intramolecular interaction of the oxygen nucleophiles.The sole product of the iodine oxidation of 3,3'-dithiodipropanol is the sultine 1,2-oxathiolane 2-oxide, which is formed after the rate-determining step, apparently via rapid cyclization of the sulfenyl iodide.The anchimeric assistance provided by the neighboring carboxylate group in the reaction of 3,3'-dithiodipropanoic acid is responsible for the pH profile of the rate of oxidative cleavage.At a given pH, the rate law for the reaction is -d/dt = kI3->(0.0905->-1 + 0.0019->-2).The inverse second term in iodide ion not has been observed previously in kinetic studies of disulfide reactions and is interpreted as evidence for a disulfide-iodonium complex.