1633-83-6

Basic information

• Product Name: 1,4-Butane sultone
• Synonyms: 1,4-butylenesulfone;1,4-Butylsultone;4-Hydroxy-1-butanesulfonicacid;butanesulfone;butanesultone;delta-butanesultone;delta-valerosultone;-Sultone
• CAS NO: 1633-83-6
• Molecular Formula: C₄H₈O₃S
• Molecular Weight: 136.17
• EINECS: 216-647-9
• Product Categories: Heterocycles;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Others;S-Containing
• Mol File: 1633-83-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 12-15 °C(lit.)
• Boiling Point: >165 °C25 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.331 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00206mmHg at 25°C
• Refractive Index: n20/D 1.464(lit.)
• Storage Temp.: Store below +30°C.
• Solubility: 54g/l (decomposition)
• Water Solubility: 54 g/L (20 ºC) decomposes
• Sensitive: Moisture Sensitive
• BRN: 110588
• CAS DataBase Reference: 1,4-Butane sultone(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Butane sultone(1633-83-6)
• EPA Substance Registry System: 1,4-Butane sultone(1633-83-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-40-68-20/21/22
• Safety Statements: 22-36/37-45-36
• RIDADR: 2810
• WGK Germany: 3
• RTECS: RP4300000
• TSCA: Yes
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 1633-83-6(Hazardous Substances Data)

Usage

Chemical Properties

Butanesultone is a viscous, clear, colourless – or yellowish/brown – and odourless liquid. When heated, vapours of butanesultone are known to form explosive mixtures with air and are reported to cause explosion hazards.

Uses

Different sources of media describe the Uses of 1633-83-6 differently. You can refer to the following data:
1. 1,4-Butane Sultone is an alkylating agent with weak carcinogenic activity.
2. 1,4-Butane sultone can be employed as a reactant in the preparation of conjugated polymers which include polybetaine, poly[2-ethynyl-N-(4-sulfobutyl)pyridinium betaine] (PESPB).It can also be used in the preparation of Bronsted acid catalysts such as 4-(succinimido)-1-butane sulfonic acid and poly(4-vinylpyridinium butane sulfonic acid) hydrogen sulfate. These catalysts facilitate the synthesis of 1-amidoalkyl-2-naphthols, substituted quinolines, and pyrano[4,3-b]pyran derivatives.

Application

1,4-Butane sultone is an intermediate widely used for sulfonated surfactants.It is also applied in photo development and electroplating.It is used as the Intermediate for the production of APIs.It used in sulfobutylether-β-cyclodextrin（SEBCD).

Safety Profile

Suspected carcinogen with experimental tumorigenic data. Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. Human mutation data reported. See also SULFONATES. When heated to decomposition it emits toxic fumes of SOx

Synthesis

Performing sulfonation on 3-butylene-1-alcohol or 3-butylene-1-chlorine serving as a raw material and a sulfonating agent under the oxidation-reduction of an initiator;performing acidification after the reaction is finished;performing lactonization by high vacuum dehydration cyclization and azeotropic dehydration cyclization;and finally refining to obtain a 1,4-butane sultone finished product.

InChI:InChI=1/C4H8O3S/c5-8(6)4-2-1-3-7-8/h1-4H2

Synthetic route

4-Chlorobutyl acetate (6962-92-1) → 1,4-butane sultone (1633-83-6)

Conditions	Yield
Stage #1: 4-Chlorobutyl acetate With sodium sulfite In water Reflux; Stage #2: With hydrogenchloride In methanol for 4h; Reflux; Stage #3: at 110℃; under 20 Torr; Temperature; Pressure; Solvent;	92%

4-hydroxy-butane-1-sulfonic acid (26978-64-3) → 1,4-butane sultone (1633-83-6)

Conditions	Yield
at 40 - 110℃; for 2h; Temperature;	88%
In water; toluene at 85℃; Temperature; Solvent;	82.77%
With ethanol; xylene Unter Entfernen des entstehenden Wassers;

4-hydroxy-1-butylthiouronium chloride → 1,4-butane sultone (1633-83-6) + 4-hydroxy-1-butanesulfonyl chloride (113309-30-1)

Conditions	Yield
With chlorine In water	A n/a B 51%

4-Mercapto-1-butanol (14970-83-3) → 1,4-butane sultone (1633-83-6) + 4-chloro-1-butanesulfonyl chloride (1633-84-7)

Conditions	Yield
With chlorine In chloroform Yields of byproduct given;	A 27% B n/a
With chlorine In chloroform Yields of byproduct given;	A n/a B 27%

4-Mercapto-1-butanol (14970-83-3) → 1,4-butane sultone (1633-83-6) + 4-chloro-1-butanesulfonyl chloride (1633-84-7) + 4-hydroxy-1-butanesulfonyl chloride (113309-30-1)

Conditions	Yield
With chlorine In dichloromethane	A 12% B 14% C 27%

4,4'-oxy-bis-butane-1-sulfonic acid (61161-42-0) → 1,4-butane sultone (1633-83-6)

Conditions	Yield
Unter vermindertem Druck;

n-Butyl chloride (109-69-3) → 1,4-butane sultone (1633-83-6) + 3-methyloxathiolane 2,2-dioxide (1121-03-5)

Conditions	Yield
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
With sulfur dioxide; chlorine Im Gluehlampenlicht; Erwaermen des Reaktionsprodukts mit Wasser und Erhitzen des danach isolierten Reaktionsprodukts unter vermindertem Druck;

tetrahydrofuran (109-99-9) → 1,4-butane sultone (1633-83-6)

Conditions	Yield
(i) AcCl, (ii) aq. Na2SO3; Multistep reaction;

4-chloro-1-butanesulfonyl chloride (1633-84-7) → 1,4-butane sultone (1633-83-6)

Conditions	Yield
With thionyl chloride In N,N-dimethyl-formamide for 22h; Ambient temperature;

4-hydroxy-1-butanesulfonyl chloride (113309-30-1) → 1,4-butane sultone (1633-83-6)

Conditions	Yield
With butan-1-ol In chloroform-d1 Rate constant; Ambient temperature; further reagent and solvent : Et3N, EtOD;

sodium 4-hydroxy-1-butanesulfinate (113309-31-2) → 1,4-butane sultone (1633-83-6) + 4-hydroxy-1-butanesulfonyl chloride (113309-30-1)

Conditions	Yield
With chlorine In dichloromethane Yield given. Yields of byproduct given;

n-Butyl chloride (109-69-3) + butan-1-ol (71-36-3) → 1,4-butane sultone (1633-83-6) + 3-methyloxathiolane 2,2-dioxide (1121-03-5)

Conditions	Yield
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;

1-butyl-3-methylimidazolium 4-chlorobutylsulfonate: → 1,4-butane sultone (1633-83-6) + 1-butyl-3-methylimidazolium chloride (79917-90-1)

Conditions	Yield
at 210℃; for 4h;

1-ethyl-3-methylimidazolium 4-chlorobutylsulfonate: → 1,4-butane sultone (1633-83-6) + 1-ethyl-3-methyl-1H-imidazol-3-ium chloride (65039-09-0)

Conditions	Yield
at 100℃; Vacuum;

1-ethyl-3-methylimidazolium 4-chlorobutylsulfonate: + 1-methyl-3-(3'-dimethylaminopropyl)imidazolium trifluoromethanesulfonate (1374458-56-6) → 1,4-butane sultone (1633-83-6) + C13H26N3O3S(1+)*Cl(1-) (1374458-57-7) + 1-ethyl-3-methylimidazolium triflate (145022-44-2)

Conditions	Yield
at 100℃; for 2h;

4-Chloro-1-butanol (928-51-8) → 1,4-butane sultone (1633-83-6)

Conditions	Yield
With potassium iodide; sodium sulfite In ethanol; water for 6h; Solvent; Reflux;

pyridine (110-86-1) + 1,4-butane sultone (1633-83-6) → 1-(4-sulfonatobutyl)pyridinium (21876-43-7)

Conditions	Yield
at 40℃; for 10h;	100%
at 70℃;	97.6%
at 70℃;	97.6%

1,4-butane sultone (1633-83-6) + 2,3,3-trimethylindoleniune (1640-39-7) → 4-(2,3,3-trimethyl-3H-indolium-1-yl)butane-1-sulfonate (54136-26-4)

Conditions	Yield
With sodium acetate In acetonitrile for 12h; Reflux;	100%
at 120℃; for 0.75h; Neat (no solvent); Microwave irradiation;	99.8%
In 1,2-dichloro-benzene at 118℃; for 25h;	97.4%

1-Butylimidazole (4316-42-1) + 1,4-butane sultone (1633-83-6) → 4-(1-butyl-1H-imidazol-3-ium-3-yl)butane-1-sulfonate

Conditions	Yield
In toluene at 60℃; for 24h; Inert atmosphere;	100%
In toluene at 60℃; for 24h; Inert atmosphere;	99.7%
In toluene for 24.0833h; Inert atmosphere;	98%

1,4-butane sultone (1633-83-6) + dimethyl(2-hydroxy-4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)amine (80233-99-4) → 4-[N,N-dimethyl(2-hydroxy-4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)ammonium]butanesulfonate

Conditions	Yield
In acetonitrile for 20h; Heating;	100%

1-methyl-1H-imidazole (616-47-7) + 1,4-butane sultone (1633-83-6) → 4-(3-methylimidazolium)butanesulfonate

Conditions	Yield
at 40℃; for 10h;	100%
at 20℃;	97.1%
at 20℃; for 48h; Inert atmosphere;	96%

1,2-dimethyl-1H-imidazole (1739-84-0) + 1,4-butane sultone (1633-83-6) → 1,2-dimethyl-3-(4-sulfonatobutyl)-1H-imidazol-3-ium (1088461-53-3)

Conditions	Yield
at 40℃; for 10h;	100%
In ethanol at 20℃; for 48h;	95%
In ethanol at 25℃; for 48h;	95%

1,4-butane sultone (1633-83-6) + 1-butyl-3-methylimidazolium chloride (79917-90-1) → 1-butyl-3-methylimidazolium 4-chlorobutylsulfonate:

Conditions	Yield
at 40℃; for 24h; Product distribution / selectivity;	100%
In Nitroethane Kinetics; Activation energy;

1,4-butane sultone (1633-83-6) + N-(2,4,6-trimethylphenyl)imidazole (25364-44-7) → 1-(2,4,6-trimethylphenyl)-3-(4-sulfonatobutyl)imidazolidinium (1197988-21-8)

Conditions	Yield
In toluene for 48h; Reflux; Inert atmosphere;	100%

1,4-butane sultone (1633-83-6) + 2,3,3-trimethyl-5-nitro-3H-indole (3484-22-8) → 2,3,3-trimethyl-1-(sulfonatobutyl)-5-nitroindolium (1364016-68-1)

Conditions	Yield
In 1,2-dichloro-benzene at 120℃;	100%
at 110℃; under 0.225023 Torr; for 12h; Sealed tube;

1,4-butane sultone (1633-83-6) + 1-(2,4,6-trimethylphenyl)-4,5-dihydro-1H-imidazole (717110-52-6) → 1-(2,4,6-trimethylphenyl)-3-(4-sulfonatobutyl)imidazolidinium

Conditions	Yield
In toluene for 48h; Reflux;	100%

1,4-butane sultone (1633-83-6) + potassium 2,3,3-trimethylindole-5-sulfonate → C15H21NO6S2*K(1+)

Conditions	Yield
With sodium acetate In acetonitrile for 12h; Reflux;	100%

1,4-butane sultone (1633-83-6) + 1,8-diazabicyclo[5.4.0]undec-7-ene (6674-22-2) → 1,8-bis(butanesulphonic acid)-diazobicyclo[5.4.0]undec-7-enium hydrogen sulfate

Conditions	Yield
Stage #1: 1,4-butane sultone; 1,8-diazabicyclo[5.4.0]undec-7-ene at 20℃; for 0.0833333h; Stage #2: With sulfuric acid at 20℃;	100%

1,4-butane sultone (1633-83-6) + acetic acid (64-19-7) + 1,8-diazabicyclo[5.4.0]undec-7-ene (6674-22-2) → C17H34N2O6S2(2+)*2C2H3O2(1-)

Conditions	Yield
Stage #1: 1,4-butane sultone; 1,8-diazabicyclo[5.4.0]undec-7-ene at 20℃; for 0.0833333h; Stage #2: acetic acid at 20℃;	100%

1,4-butane sultone (1633-83-6) + 1,8-diazabicyclo[5.4.0]undec-7-ene (6674-22-2) + trifluoroacetic acid (76-05-1) → C17H34N2O6S2(2+)*2C2F3O2(1-)

Conditions	Yield
Stage #1: 1,4-butane sultone; 1,8-diazabicyclo[5.4.0]undec-7-ene at 20℃; for 0.0833333h; Stage #2: trifluoroacetic acid at 20℃;	100%

1,4-butane sultone (1633-83-6) + dimethyl amine (124-40-3) → dimethyl(4-sulfonatobutyl)ammonium (89585-26-2)

Conditions	Yield
In 1,4-dioxane; water at 4 - 20℃;	99%
In water at 20℃; for 24h;	94%
In water at 20℃; for 24h;	94%

1,4-butane sultone (1633-83-6) + 2,3,3-trimethylbenzo[e]indole (41532-84-7) → 4-(1,1,2-trimethyl-1H-benzo[e]indol-3-ium-3-yl)butane-1-sulfonate (63149-24-6)

Conditions	Yield
at 120℃; for 2h;	99%
In sulfolane at 120 - 130℃;	92%
With 1,2-dichloro-benzene In diethyl ether at 120℃; for 18h; Inert atmosphere; Darkness;	90%

1,4-butane sultone (1633-83-6) + dimethyl(2-hydroxy-4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyl)amine (80233-98-3) → 4-[dimethyl(2-hydroxy-4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyl)ammonium]butanesulfonate

Conditions	Yield
In acetonitrile for 20h; Heating;	99%

1,4-butane sultone (1633-83-6) + 1-dodecylimidazole (4303-67-7) → C19H36N2O3S

Conditions	Yield
In acetonitrile at 80℃; for 48h;	99%
at 0 - 50℃;

1,4-butane sultone (1633-83-6) + 1-(3-(trimethoxysilyl)propyl)-1,3,5,7-tetraazaadamantan-1-ium chloride → C24H51N4O12S3Si(1+)*Cl(1-)

Conditions	Yield
at 25℃; for 72h;	99%

1,4-butane sultone (1633-83-6) + 6-phenyl-5H-[1,3]dioxolo[4,5-f]indole (64943-90-4) → C19H18NO5S(1-)*Na(1+)

Conditions	Yield
Stage #1: 6-phenyl-5H-[1,3]dioxolo[4,5-f]indole With sodium hydride In tetrahydrofuran; mineral oil for 0.666667h; Cooling with ice; Stage #2: 1,4-butane sultone In tetrahydrofuran; mineral oil at 100℃; for 4h;	99%

1,4-butane sultone (1633-83-6) + 5-(2,3-dimethyl-3H-indol-3-yl)pentanoic acid → 3-(4-carboxybutyl)-2,3-dimethyl-1-(4-sulfonatobutyl)indoleninium

Conditions	Yield
In 1,2-dichloro-benzene at 118℃; for 25h;	98.9%

1,4-butane sultone (1633-83-6) + 1-ethyl-3-methyl-1H-imidazol-3-ium chloride (65039-09-0) → 1-ethyl-3-methylimidazolium 4-chlorobutylsulfonate:

Conditions	Yield
In acetonitrile for 12h; Inert atmosphere; Reflux;	98%
at 40℃; for 24h; neat (no solvent);

1,4-butane sultone (1633-83-6) + 2,5-dibromohydroquinone (14753-51-6) → 2,5-dibromo-1,4-bis(4-sulfonatobutoxy)phenylene disodium salt

Conditions	Yield
With sodium hydroxide In ethanol at 80℃; for 21h;	98%
With sodium hydroxide In ethanol at 90℃; for 20h;	96%
With sodium hydroxide In ethanol for 20h; Reflux;	96%
With sodium hydroxide In ethanol for 20h; Reflux;	90.8%

1,4-butane sultone (1633-83-6) + N,N,N',N'-tetramethylguanidine (80-70-6) → 4-(1,1,3,3-tetramethylguanidine-2-yl)butylsulfonic acid (1294516-89-4)

Conditions	Yield
In toluene at 80 - 85℃; for 4h;	98%

1,4-butane sultone (1633-83-6) + trifluorormethanesulfonic acid (1493-13-6) + 1-tetradecylimidazole (54004-47-6) → 3-tetradecyl-1-(4-sulfobutyl)imidazolium trifluoromethanesulfonate (1374561-43-9)

Conditions	Yield
Stage #1: 1,4-butane sultone; 1-tetradecylimidazole at 40℃; for 10h; Stage #2: trifluorormethanesulfonic acid at 80℃; for 12h;	98%

1,4-butane sultone (1633-83-6) + 5,11,17,23,29,35,41,47-octakis(tert-butyl)-49,50,51,52,53,54,55,56-octakis(hydroxy)calix[8]arene (68971-82-4) → 5,11,17,23,29,35,41,47-octa-tert-butyl-49,50,51,52,53,54,55,56-octakis-(4-butylsulphonic acid)calix[8]arene

Conditions	Yield
Stage #1: 5,11,17,23,29,35,41,47-octakis(tert-butyl)-49,50,51,52,53,54,55,56-octakis(hydroxy)calix[8]arene With n-butyllithium In dimethyl sulfoxide at 0℃; Stage #2: 1,4-butane sultone at 25℃; for 96h;	98%
Stage #1: 5,11,17,23,29,35,41,47-octakis(tert-butyl)-49,50,51,52,53,54,55,56-octakis(hydroxy)calix[8]arene With n-butyllithium In hexane; dimethyl sulfoxide at 0 - 25℃; for 24h; Inert atmosphere; Stage #2: 1,4-butane sultone In hexane; dimethyl sulfoxide at 25℃; Inert atmosphere;	86%

1,4-butane sultone (1633-83-6) + calix[8]arene (82452-93-5) → 49,50,51,52,53,54,55,56-octakis-(4-butylsulphonic acid)calix[8]arene

Conditions	Yield
Stage #1: calix[8]arene With n-butyllithium In hexane; dimethyl sulfoxide at 0 - 25℃; for 24h; Inert atmosphere; Stage #2: 1,4-butane sultone In hexane; dimethyl sulfoxide at 25℃; Inert atmosphere;	98%
Stage #1: calix[8]arene With n-butyllithium In dimethyl sulfoxide at 0℃; Stage #2: 1,4-butane sultone at 25℃; for 96h;	86%

1,2-dimethyl-1H-imidazole (1739-84-0) + 1,4-butane sultone (1633-83-6) + trifluorormethanesulfonic acid (1493-13-6) → 1-butylsulfonic-2,3-dimethylimidazolium trifluoromethanesulfonate (1402671-71-9)

Conditions	Yield
Stage #1: 1,2-dimethyl-1H-imidazole; 1,4-butane sultone at 60℃; for 2h; Stage #2: trifluorormethanesulfonic acid at 60℃; for 1h;	98%
Stage #1: 1,2-dimethyl-1H-imidazole; 1,4-butane sultone at 30℃; Stage #2: trifluorormethanesulfonic acid

1-vinylimidazole (1072-63-5) + 1,4-butane sultone (1633-83-6) → 1-(butyl-4-sulfonate)-3-vinylimidazolium

Conditions	Yield
at 70℃; for 10h; Inert atmosphere;	98%
In acetonitrile at 0 - 85℃; for 72h;	63%
In acetonitrile at 85℃; for 120h; Inert atmosphere;
In toluene at 60℃; for 24h;

piperidine (110-89-4) + carbon disulfide (75-15-0) + 1,4-butane sultone (1633-83-6) → potassium 4-((piperidine-1-carbonothioyl)thio)butane-1-sulfonate

Conditions	Yield
Stage #1: piperidine; carbon disulfide With potassium phosphate In water at 20℃; for 0.166667h; Stage #2: 1,4-butane sultone In water at 20℃;	98%

Upstream product

• 61161-42-0 4,4'-oxy-bis-butane-1-sulfonic acid 
• 109-69-3 n-Butyl chloride 
• 26978-64-3 4-hydroxy-butane-1-sulfonic acid 
• 109-99-9 tetrahydrofuran 
• 14970-83-3 4-Mercapto-1-butanol 
• 1633-84-7 4-chloro-1-butanesulfonyl chloride 
• 6962-92-1 4-Chlorobutyl acetate 
• 928-51-8 4-Chloro-1-butanol 
• 1374458-56-6 1-methyl-3-(3'-dimethylaminopropyl)imidazolium trifluoromethanesulfonate 
• 71-36-3 butan-1-ol 
• 113309-31-2 sodium 4-hydroxy-1-butanesulfinate 
• 113309-30-1 4-hydroxy-1-butanesulfonyl chloride 

Downstream Products

• 21876-43-7 pyridinium propyl sulfobetaine 
• 71205-44-2 2-methyl-1-(4-sulfonatobutyl)-quinolinium 
• 55526-95-9 N-(δ-sulfonatobutyl)-2-methyl-benzothiazole 
• 3944-72-7 1-octanesulfonic acid 
• 63815-76-9 5-methoxy-2-methyl-3-(4-sulfo-butyl)-benzoselenazolium betaine 
• 13595-73-8 hexane-1-sulfonic acid 
• 62607-64-1 4-phenyl-butane-1-sulfonic acid 
• 14064-34-7 4-amino-1-butanesulfonic acid 
• 55015-44-6 4-(4-Hydroxy-phenylamino)-butane-1-sulfonic acid 
• 91760-72-4 2-(2-nitro-phenyl)-[1,2]thiazinane 1,1-dioxide 
• 94624-92-7 4-anilino-1-butanesulfonic acid 
• 55015-43-5 4-(2-Hydroxy-phenylamino)-butane-1-sulfonic acid 
• 54960-65-5 N-tris[hydroxymethyl]-4-aminobutanesulfonic acid 
• 54960-63-3 4-(3-Phenyl-thioureido)-butane-1-sulfonic acid 

Relevant articles and documents

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Synthesis method of high-purity 1,4-butane sultone

The invention discloses a synthesis method of high-purity 1,4-butane sultone. The synthesis method comprises the steps: 1, adding 4-chlorobutanol and a sodium sulfite solution into an alcohol solvent,raising the temperature until carrying out reflowing for 6 h, ending the reflowing to obtain a mixed solution A, concentrating the mixed solution A to recover the alcohol solvent, then, adding hydrochloric acid for acidification, carrying out concentration until a material becomes viscous, then, adding the alcohol solvent, separating out a sodium chloride crystal, carrying out filtration, and concentrating filtrate to recover the alcohol solvent so as to obtain 4-hydroxybutane sulfonic acid; 2, carrying out continuous flash evaporation dehydration on 4-hydroxybutane sulfonic acid at the vacuum degree of 1-8 mmHg and the temperature of 130-165 DEG C to obtain industrial-grade 1,4-butane sultone; and 3, adding an azeotrope into industrial-grade 1,4-butane sultone, carrying out normal-pressure fractional distillation to recover the azeotrope, then, carrying out reduced-pressure fractional distillation at the vacuum degree of 2-4 mmHg, and collecting fractions with the temperature of 120-121 DEG C to obtain high-purity 1,4-butane sultone. The method is simple and environment-friendly, the sulfonation yield is greatly increased, and the purity and yield of 1,4-butane sultone are greatly increased.

1,4-butane sultone and synthesis process thereof

1,4-butane sultone and a synthesis process thereof relate to the field of fine chemical engineering. The synthesis process comprises the steps: performing sulfonation on 3-butylene-1-alcohol or 3-butylene-1-chlorine serving as a raw material and a sulfonating agent under the oxidation-reduction of an initiator; performing acidification after the reaction is finished; performing lactonization by high vacuum dehydration cyclization and azeotropic dehydration cyclization; and finally refining to obtain a 1,4-butane sultone finished product. The synthesis process of the 1,4-butane sultone, provided by the invention, is easily available in raw materials, few in synthesis steps, high in yield, high in product purity and suitable for industrialized production. The invention also provides the 1,4-butane sultone which is prepared by the synthesis process and has high purity.