- Rhodium-catalyzed cyclization of acceptor-substituted biphenyl α-diazoketones: A study of the substitution effect on chemoselectivity
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A range of biphenyl α-diazoketones containing various electron-withdrawing groups (EWG = COCH3, CN, CO2Et, COPh, SO2CH3, SO2Ph) on diazo carbon has been investigated for rhodium(ii)-catalyzed intramol
- Chen, Kuo-Hsin,Chiang, Yi-Jung,Zhu, Jia-Liang
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- N-Iodosuccinimide and dioxygen in an air-enabled synthesis of 10-phenanthrenols under sunlight
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Using a catalytic amount ofN-iodosuccinimide (NIS) in combination with O2in air, an aerobic oxidative reaction was carried out to efficiently and scalably construct a series of 10-phenanthrenols under sunlight at room temperature. Mechanistic studies reveal that H2O2generatedin situwas responsible for the conversion of I2to IOH as a potential initiator for later catalytic cycle.
- Guo, Jia-Dong,Yang, Xiu-Long,Chen, Bin,Tung, Chen-Ho,Wu, Li-Zhu
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supporting information
p. 7193 - 7198
(2021/09/28)
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- N-Bromosuccinimide-Induced C-H Bond Functionalization: An Intramolecular Cycloaromatization of Electron Withdrawing Group Substituted 1-Biphenyl-2-ylethanone for the Synthesis of 10-Phenanthrenol
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An NBS-induced intramolecular cycloaromatization for the synthesis of 10-phenanthrenols from electron-withdrawing group substituted 1-biphenyl-2-ylethanones is described. The in situ generated bromide was designed to act as an initiator for the radical C-H bond activation. An oxidative cross-dehydrogenative coupling reaction of a highly active C-H bond with an inert C-H bond readily occurs under mild conditions without the need for transition metals or strong oxidants.
- Jiang, Ya-Ting,Yu, Zhen-Zhen,Zhang, Ya-Kai,Wang, Bin
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supporting information
p. 3728 - 3731
(2018/07/25)
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- Pyrazolotriazines as inhibitors of nucleases
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The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3 and R4 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.
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Paragraph 0060; 0061; 0062; 0063; 0064; 0097-0102
(2016/01/12)
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