- Partially saturated indeno[1,2-b]indole derivatives via deoxygenation of heterocyclic α-hydroxy-N,O-hemiaminals
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A series of 3-aminocyclohex-2-enones were reacted with indane-1,2,3-trione monohydrate (ninhydrin) yielding 4b,9b-dihydroxyindeno[ 1,2-b]indoles that were deoxygenated to indeno[1,2-b]indoles. Georg Thieme Verlag Stuttgart.
- Hemmerling, Hans-Joerg,Reiss, Guido
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experimental part
p. 985 - 999
(2009/12/01)
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- Heterocycles from Nitroalkenes, I. - Pyrroles via Michael Addition of Enamines
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The principle of a general pyrrole synthesis via cyclising Michael addition of enamines to nitroalkenes is outlined.Condensation of the nitroalkene 7 with various enamines yields the pyrroles 9, 11, 12, 14, 15, 17, 18, 20, 22, 26, 27, 29, and 31.Reaction of 1-nitro-1,2-diphenylethene and the enamine 8 furnishes the pyrroloisoquinoline 32 while addition of 8 to 1-nitrocyclohexene is followed by ring closure to the indoloisoquinoline 33.The pyrrole 14 can also be prepared by multiple-component syntheses, further examples of which are the syntheses of the pyrroles 35, 36, 37, and 38.Scope and advantages of the presented pyrrole synthesis are discussed.
- Meyer, Horst
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p. 1534 - 1544
(2007/10/02)
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