27292-50-8

Basic information

• Product Name: 3-PIPERIDINOPHENOL
• Synonyms: 3-PIPERIDINOPHENOL;Nsc23894;3-(Piperidin-1-yl)phenol
• CAS NO: 27292-50-8
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.24
• Mol File: 27292-50-8.mol

Chemical Properties

• Melting Point: 123-124 °C
• Boiling Point: 338.9 °C at 760 mmHg
• Flash Point: 183.6 °C
• Appearance: /
• Density: 1.106 g/cm³
• Vapor Pressure: 4.84E-05mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.37±0.10(Predicted)
• CAS DataBase Reference: 3-PIPERIDINOPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PIPERIDINOPHENOL(27292-50-8)
• EPA Substance Registry System: 3-PIPERIDINOPHENOL(27292-50-8)

Safety Data

• Hazardous Substances Data: 27292-50-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
3-Piperidinophenol is used as a key intermediate in the synthesis of various pharmaceuticals and organic compounds, contributing to the development of new medications and chemical products.
Used in Medical Applications:
3-Piperidinophenol is used as an anti-inflammatory and anesthetic agent for its potential therapeutic effects in managing pain and reducing neuroinflammation.
Used in Pharmaceutical Formulation:
3-Piperidinophenol is used as a stabilizer in the formulation of pharmaceutical products to prevent the degradation of active ingredients, thereby enhancing the shelf life and efficacy of medications.

InChI:InChI=1/C11H15NO/c13-11-6-4-5-10(9-11)12-7-2-1-3-8-12/h4-6,9,13H,1-3,7-8H2

Upstream product

• 32040-06-5 N-(3-methoxyphenyl)piperidine 
• 110-89-4 piperidine 
• 108-43-0 3-monochlorophenol 
• 591-20-8 3-Bromophenol 
• 111-24-0 1,5-dibromo-pentane 
• 591-27-5 m-Hydroxyaniline 
• 536-90-3 m-Anisidine 
• 111-29-5 1 ,5-pentanediol 
• 628-76-2 1,5-dichloropentane 
• 27969-75-1 3‐(piperidin‐1‐yl)aniline 
• 16179-65-0 3-(piperidin-1-yl)cyclohex-2-en-1-one 
• 108-94-1 cyclohexanone 

Downstream Products

• 96649-16-0 3-(1-piperidinyl)phenyl diethylcarbamate 
• 1152500-28-1 C₁₅H₂₁NO 
• 27292-59-7 2-nitroso-5-(piperidin-1-yl)phenol 
• 1032716-21-4 1-(3-methoxy-4-nitrosophenyl)piperidine 
• 32040-06-5 N-(3-methoxyphenyl)piperidine 
• 96649-21-7 2-hydroxy-4-(piperidin-1-yl)benzaldehyde 
• 1229439-27-3 5,5'-bis-piperidino-2,2'-methandiyl-di-phenol 

Relevant articles and documents

Formation of 3-Aminophenols from Cyclohexane-1,3-diones

meta-Aminophenols are formed by the action of DBU on 3-amino-2-chlorocyclohex-2-en-1-ones at room temperature in MeCN. The chloro compounds are generated by treating 3-aminocyclohex-2-en-1-ones with the easily prepared halogenating agent BnNMe3·ICl2 in Me

NEAR-INFRARED NERVE-SPARING FLUOROPHORES

Provided are far red to near-infrared nerve-sparing fluorescent compounds, compositions comprising them, and methods of their use in medical procedures.

NERVE-SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION

Nerve-specific fluorophore formulations for direct or systemic administration are described. The formulations can be used in fluorescence-guided surgery (FGS) to aid in nerve preservation during surgical interventions.

Intermolecular Multiple Dehydrogenative Cross-Couplings of Ketones with Boronic Acids and Amines via Copper Catalysis

An efficient and versatile oxidative coupling reaction was developed for the synthesis of valuable β-functionalized unsaturated ketones and meta-substituted phenols. In the case of intramolecular reactions, achieving rapid molecular complexity through multiple dehydrogenative couplings is already a well-established strategy. Herein, we report an intermolecular multiple dehydrogenative coupling between ketones and nucleophilic amines or boronic acids using inexpensive copper(I) oxide as a catalyst. This method provides a facile access to highly desirable chemical products such as α,β-unsaturated ketones, enaminones, and synthetically relevant meta-substituted phenols. (Figure presented.).

Inter-alkane amidogen phenolic synthetic method (by machine translation)

Inter-alkane amidogen phenolic synthetic method, its characteristic is: 1st step, between the two alkane amidogen acyl aniline and sulfuric acid aqueous solution mixing and heating to 50 - 110 °C, thermal insulation reaction of aniline [...] sulfuric acid aqueous solution; 2nd step, continue to drip the sodium nitrite aqueous solution, sodium nitrite aqueous solution for dropping temperature of - 10 - 20 °C, drop bi yu 5 - 30 °C insulation, [...] aniline obtained diazonium salt of the sulfuric acid aqueous solution; 3rd step, [...] aniline diazonium salt of the sulfuric acid aqueous solution is directly heated to 45 - 110 °C, thermal insulation, in the hydrolysis reaction of the diazonium salt, cooling after treatment, to obtain the product between two alkane amidogen phenol; three-step required by the reaction of sulfuric acid in the 1st step reaction in the finished disposable adding; a three-step reaction in a finish step by step in the pot. The method of the invention with raw materials are cheap, abundant, synthetic high security of the process, the product yield is high, the three waste less pollution and the like, has high industrial value. (by machine translation)

Method for continuously synthesizing meta-di-alkane aminophenol

The invention discloses a method for continuously synthesizing meta-di-alkane aminophenol. The technical scheme includes that continuous diazotization or continuous diazonium salt hydrolysis or continuous diazotization and diazonium salt hydrolysis is carried on raw materials such as di-alkane aminophenol, sodium nitrite and sulfuric acid, and after-treatment such as extraction is carried out to obtain the meta-di-alkane aminophenol which is a product. The method has the advantages that the raw materials can come from sufficient sources and are low in cost, processes for synthesizing the meta-di-alkane aminophenol are high in safety, products are high in yield, the method is little in waste gas, wastewater and industrial residue pollution, is green and environmental friendly and has a highindustrialization value, and the like.

Synthesis of Aminobenzopyranoxanthenes with Nitrogen-Containing Fused Rings

An efficient and practical method for the synthesis of a variety of aminobenzopyranoxanthenes (ABPXs) with different nitrogen-containing fused rings was developed. On the basis of the mechanistic studies of the formation of the xanthene framework, the presented methodology was developed to facilitate access to previously inaccessible asymmetric ABPXs.

ZnAl2O4–Bi2O3 composite nano-powder as an efficient catalyst for the multi-component, one-pot, aqueous media preparation of novel 4H-chromene-3-carbonitriles

Abstract: A composite structure of ZnAl2O4–Bi2O3 nanopowder was prepared from the reaction of a watery solution of Zn(NO3)2, Al(NO3)3, and Bi(NO3)3 with a dilute solution of amino ethanol in water via a simple precipitation-complexation method. The as-prepared composite was used for the one-pot synthesis of 2-amino-4-aryl-7-(pyrrolidin-1-yl)-4H-chromene-3-carbonitrile, 2-amino-4-aryl-7-(piperidin-1-yl)-4H-chromene-3-carbonitrile, 2-amino-4-aryl-7-(1H-pyrrol-1-yl)-4H-chromene-3-carbonitrile, 2-amino-4-aryl-6-(2-(piperidin-1-yl)ethyl)-4H-chromene-3-carbonitrile and 2-amino-4-aryl-6-(1H-pyrrol-1-yl)-4H-chromene-3-carbonitrile derivatives. This procedure is very simple and affords excellent yields. Graphical Abstract: [Figure not available: see fulltext.]

Synthesis of N-arylsubstituted pyrrolidines and piperidines by reaction of anilines with α,ω-diols catalyzed by FeCl3·6H2O in carbon tetrachloride

N-Arylpyrrolidines and N-arylpiperidines were synthesized in 20-88% yields by the reaction of aniline and aniline derivatives with 1,4-butane- and 1,5-pentanediols in the presence of Fecontaining catalysts and carbon tetrachloride. 1,4-Butane- and 1,5-pentanediols are partially chlorinated under the reaction conditions to give chlorohydrins, which subsequently undergo Nheterocyclization with anilines to give N-arylpyrrolidines and N-arylpiperidines.

Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells

Under hypoxia, cancer cells consume glucose and release lactate at a high rate. Lactate was recently documented to be recaptured by oxygenated cancer cells to fuel the TCA cycle and thereby to support tumor growth. Monocarboxylate transporters (MCT) are the main lactate carriers and therefore represent potential therapeutic targets to limit cancer progression. In this study, we have developed and implemented a stepwise in vitro screening procedure on human cancer cells to identify new potent MCT inhibitors. Various 7-substituted carboxycoumarins and quinolinone derivatives were synthesized and pharmacologically evaluated. Most active compounds were obtained using a palladium-catalyzed Buchwald-Hartwig type coupling reaction, which proved to be a quick and efficient method to obtain aminocarboxycoumarin derivatives. Inhibition of lactate flux revealed that the most active compound 19 (IC 50 11 nM) was three log orders more active than the CHC reference compound. Comparison with warfarin, a conventional anticoagulant coumarin, further showed that compound 19 did not influence the prothrombin time which, together with a good in vitro ADME profile, supports the potential of this new family of compounds to act as anticancer drugs through inhibition of lactate flux.