An efficient method for the preparation of 2-(chloromethyl)acrylonitrile (7) is reported. The Mannich reaction of cyanoacetic acid with paraformaldehyde and morpholine afforded the allylic amine 6a which was converted into the chloride 7 on treatment with isobutyl chloroformate at room temperature.
2-(Substitutedpiperidylmethyl)propene and propane nitriles
Antimicrobial agents suitable for use in aqueous systems for their preservation against biodeterioration include substitutedpiperidinomethyl-propenenitriles and propanenitriles. The unsaturated compounds are prepared by reaction of a suitable piperidine w
-
(2008/06/13)
Treatment of pain, fever, and inflammation with compositions containing 2-(substitutedpiperidinomethyl)propane and propene nitriles
A method of treating pain, fever, and inflammation and pharmaceutical compositions for use therein, wherein the active ingredient comprises a compound of the formula: STR1 wherein A and R1 represent various substituents.
-
(2008/06/13)
3-Pyrazolidinone derivatives
3-Pyrazolidinone compounds having a solubility of at least 12 grams/liter in an aqueous medium of pH 9 of the formula: STR1 wherein R is a mononuclear phenyl group having substituents in the 3, 4, or 5 positions with a total of no more than 4 non-metallic
-
(2008/06/13)
More Articles about upstream products of 27315-95-3