The reduction of specific disulfides with titanium(III) chloride
The reaction between titanium(III) chloride and disulfides was investigated.Aryl and alkyl disulfides did not react while heterocyclic aromatic disulfides with a nitrogen α to the sulfur were reduced to the corresponding thiols.Products were identified and characterized by nuclear magnetic resonance and inrared spectra; and melting point comparisons with authentic compounds.The reductions occurred only in the presence of citrate and were found to require 2 moles of titanium(III) per mole of disulfide.
Akers, Hugh A.,Vang, Meng C.,Updike, Tracie D.
p. 1364 - 1366
(2007/10/02)
Studies of thiaheterocyclic derivatives. I. Synthesis and pharmacological screening
The synthesis of several sulfured heterocyclic compounds has been carried out. They were examined for their antithyroid activity by preliminary screening in rats. The most interesting products are 1-methylimidazolylpyrimidylsulfides. They do not appear as 'pro drugs' of MMI.
Delarge,Thunus,Beckers,et al.
p. 559 - 565
(2007/10/02)
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