2127-10-8

Basic information

• Product Name: 2,2'-DITHIOBIS(5-NITROPYRIDINE)
• Synonyms: DTNP;BIS(5-NITRO-2-PYRIDYL) DISULFIDE;2,2'-DITHIOBIS(5-NITROPYRIDINE);2,2’-dithiobis(5-nitro-pyridin;1,2-Bis(5-nitropyridin-2-yl)disulfane;Bis(5-nitro-2-pyridyl) disulfide, DTNP;5-nitro-2-(5-nitropyridin-2-yl)disulfanylpyridine;5-nitro-2-(5-nitropyridin-2-yl)disulfanyl-pyridine
• CAS NO: 2127-10-8
• Molecular Formula: C₁₀H₆N₄O₄S₂
• Molecular Weight: 310.31
• EINECS: 218-344-7
• Product Categories: blocks;Pyridines
• Mol File: 2127-10-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 155-157 °C(lit.)
• Boiling Point: 139°C (rough estimate)
• Flash Point: 264.8°C
• Appearance: /
• Density: 1.6508 (rough estimate)
• Refractive Index: 1.6000 (estimate)
• Storage Temp.: Store at RT.
• PKA: -2.88±0.29(Predicted)
• BRN: 305413
• CAS DataBase Reference: 2,2'-DITHIOBIS(5-NITROPYRIDINE)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-DITHIOBIS(5-NITROPYRIDINE)(2127-10-8)
• EPA Substance Registry System: 2,2'-DITHIOBIS(5-NITROPYRIDINE)(2127-10-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 36/37/39
• WGK Germany: 3
• RTECS: UT2964000
• Hazardous Substances Data: 2127-10-8(Hazardous Substances Data)

Usage

Uses

2,2′-Dithiobis(5-nitropyridine) was employed:as cysteine-activating reagent to study the NMR of G protein-coupled receptors in the deprotection assays for protected selenocysteine-containing peptidesfor deprotecting p-methoxybenzyl groups and acetamidomethyl groups from the side-chains of cysteine and selenocysteineto remove the p-methoxybenzyl protecting group from cysteine and selenocysteine side-chains

General Description

2,2′-Dithiobis(5-nitropyridine) is an aromatic disulphide.

Upstream product

• 456-24-6 2-Fluoro-5-nitropyridine 
• 5418-51-9 5-nitro-2-hydroxypyridine 
• 4548-45-2 2-chloro-5-nitropyridine 
• 2127-09-5 2-mercapto-5-nitropyridine 

Downstream Products

• 195967-03-4 3'-deoxy-5'-O-dimethoxytrityl-3'-S-(5-nitropyridyl-2-disulfanyl)thymidine 
• 1241507-41-4 3-[3-(2-morpholin-4-yl-ethoxy)-phenyl]-6-(5-nitro-pyridin-2-ylsulfanyl)-[1,2,4]triazolo[4,3-a]pyridine 
• 2127-09-5 5-nitro-1H-pyridine-2-thione 

Relevant articles and documents

IF5 affects the final stage of the Cl-F exchange fluorination in the synthesis of pentafluoro-λ6-sulfanyl-pyridines, pyrimidines and benzenes with electron-withdrawing substituents

A difficult chlorine-fluorine (Cl-F) exchange fluorination reaction in the final stage of the preparation of pentafluoro-λ6-sulfanyl-(hetero)arenes having electron-withdrawing substituents has now been elucidated through the use of iodine pentafluoride. A major side-reaction of C-S bond cleavage was sufficiently inhibited by the potential interaction between F and I with a halogen bonding.

NOVEL PEPTIDE COMPOUND

A novel compound of the formula (1): wherein X is a tyrosine residue or a methionine residue; Y and Z each are a single bond or the like; R1 is a hydrogen atom or the like; R2 is a hydroxy group or the like; R3 is a hydrogen atom, alkyl group, amino group or the like; R4 is a hydrogen atom, alkyl group, carboxy group or the like; m is 1 or 2; and n is an integer of 0 to 2, with the proviso that when n is 0, R3 is a hydrogen atom or an alkyl group, or a pharmaceutically acceptable salt thereof, and its use in cancer immunotherapy.

Base-protected nucleotide analogs with protected thiol groups

The present invention is directed to protected thiol analogs of pyrimidine bases for syntheses of DNA and RNA by chemical or enzymatic methods. The subject analogs include reagents suitable for DNA or RNA synthesis via phosphoramidite, H-phosphonate or phosphotriester chemistry as well a reagents suitable for use by RNA and DNA polymerase, including thermostable polymerases employed by PCR or other nucleic acid amplification techniques. The nucleotide analogs synthesized by methods of this invention can thus be incorporated into oligonucleotides or polynucleotides, deprotected and derivatized with a functional group. In some cases the protecting groups are themselves antigenic and may be left on the oligonucleotides or polynucleotides for detection with antibodies. A method of synthesizing oligonucleotides with a functional group using the subject nucleotide analogs is also provided.