28051-68-5

Basic information

• Product Name: 2-Methylpropenaloxime
• Synonyms: 2-Methylpropenaloxime;3-Methyl-1-aza-1,3-butadien-1-ol
• CAS NO: 28051-68-5
• Molecular Formula: C₄H₇NO
• Molecular Weight: 85.11
• Mol File: 28051-68-5.mol

Chemical Properties

• Boiling Point: 156.6°C (rough estimate)
• Appearance: /
• Density: 1.0408 (rough estimate)
• Refractive Index: 1.4340 (estimate)
• CAS DataBase Reference: 2-Methylpropenaloxime(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methylpropenaloxime(28051-68-5)
• EPA Substance Registry System: 2-Methylpropenaloxime(28051-68-5)

Safety Data

• Hazard Codes: 3:
• Safety Statements: x. See also ALDEHYDES." target="_blank">Can form heat;sensitive explosive polymeric peroxides. When heated to decomposition it e
• Hazardous Substances Data: 28051-68-5(Hazardous Substances Data)

Upstream product

• 78-85-3 2-methylpropenal 
• 98275-70-8 α-dimethylamino-isobutyraldehyde-oxime 

Downstream Products

• 126-98-7 methacrylonitrile 
• 78-85-3 2-methylpropenal 
• 84402-27-7 O-benzoyl-2-methylpropenal oxime 
• 104293-90-5 3-butyl-5-methylpyridine 
• 27012-26-6 2-n-butyl-5-methylpyridine 
• 28712-62-1 3-methyl-5,6,7,8-tetrahydroquinoline 
• 1658-08-8 1,2,3,4,5,6,7,8-octahydroacridine 
• 91737-29-0 C₁₁H₁₁ClN₂O₂ 
• 591-22-0 3,5-Lutidine 
• 1123-96-2 2-ethyl-3,5-dimethylpyridine 
• 2687-88-9 3,5-dimethyl-4-ethylpyridine 
• 28712-61-0 6,7-dihydro-3-methyl-5H-1-pyrindine 
• 34421-99-3 1,2,3,5,6,7-hexahydrodicyclopenta[b,e]pyridine 
• 84817-47-0 3-Isopropenyl-5-phenyl-4,5-dihydro-isoxazole 

Relevant articles and documents

A short and flexible route to tetrahydropyran-4-ones via conjugated nitrile oxides cycloaddition and oxa-Michael cyclization: A concise diastereoselective total synthesis of (±)-diospongin A

A short and flexible [3+2+1] synthetic strategy was developed for the synthesis of substituted tetrahydropyran-4-ones, featuring [3+2]-cycloaddition of α,β-unsaturated nitrile oxides and alkenes and oxa-Michael cyclization in a 6-endo-trig fashion. The efficiency of this synthetic strategy was further demonstrated by the concise total synthesis of (±)-diospongin A in 8 steps with 20.2% yield. This journal is The Royal Society of Chemistry.

Synthesis of alkyl- and aryl-substituted pyridines from (α,β-unsaturated) imines or oximes and carbonyl compounds

Reaction of a variety of (α,β-unsaturated) imines or oximes with aliphatic aldehydes or cyclic ketones in the presence of a secondary amine afforded alkyl-, and/or aryl-, and/or cycloalkyl-substituted pyridines. To explain their formation, a hetero Diels-Alder reaction has been postulated, in which an 1-aza-1,3-butadiene reacts with an in situ generated enamine.