- Process for producing amidine sulfonic acids
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An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): STR1 with H2 O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.
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- Propargyl-substituted 2-phenylamino-2-imidazolines and salts thereof
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Compounds of the formula STR1 wherein R1, R2 and R3, which may be identical to or different from each other, are each hydrogen, fluorine, chlorine, bromine, methyl, ethyl, methoxy or trifluoromethyl, and R4 and R5 are each hydrogen or propargyl, but other than both hydrogen or both propargyl at the same time, And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as analgesics and hypotensives.
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