28314-82-1Relevant articles and documents
ANTIBACTERIAL COMPOUNDS AND NEW USES THEREOF
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Page/Page column 97; 98, (2017/04/11)
This invention relates to a series of compounds of formula (I) for use in treating infections caused by obligate anaerobic bacteria, including Clostridium difficile, and to methods of treating said infections by administering said compounds. The compounds can be used against strains of obligate anaerobic bacteria that have developed resistance to other antibiotics. Many compounds used in the invention contain a tricyclic ring system.
ANTIBACTERIAL COMPOUNDS
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Page/Page column 66-67, (2017/04/11)
This invention relates to antibacterial and anti-mycobacterial drug compounds of formula (I). It also relates to pharmaceutical formulations of antibacterial drug compounds of formula (I). It also relates to uses of the derivatives in treating bacterial i
In vitro and in vivo identification of novel positive allosteric modulators of the human dopamine D2 and D3 receptor
Wood, Martyn,Ates, Ali,Andre, Veronique Marie,Michel, Anne,Barnaby, Robert,Gillard, Michel
supporting information, p. 303 - 312 (2016/02/26)
Agonists at dopamine D2 and D3 receptors are important therapeutic agents in the treatment of Parkinson's disease. Compared with the use of agonists, allosteric potentiators offer potential advantages such as temporal, regional, and phasic potentiation of
SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
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Paragraph 0236; 0237; 0238, (2016/09/26)
Provided is a sulfonamide derivative represented by the following general formula (1) and having an α4 integrin inhibitory effect with high selectivity with a low effect on α4β1 and a high effect on α4β7, or a pharmaceutically acceptable salt thereof (in the general formula (1), A, B, D, E, R41, and a to h are as described in the description).
CARBAZOLE DERIVATIVES
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Page/Page column 72; 73, (2016/05/24)
Disclosed are compounds of Formula (I): (I) or a salt thereof, wherein Q, R1a, R1b, R2a, R2b, R3, R4, R5a, R5b, R6a, R6c, R7a, R7b, R7c, and R7d are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
INDOLE CARBOXAMIDE COMPOUNDS
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Paragraph 0297-0298, (2016/05/19)
Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR4 or N; R1, R2, R3, R4, and A are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
TRICYCLIC ATROPISOMER COMPOUNDS
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Page/Page column 49-50, (2016/06/06)
Disclosed are compounds of Formula (I): or a salt thereof, wherein Q is: or; and X, R1a, R1b, R3, R4, and R5 are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bru
ANTIBACTERIAL COMPOUNDS
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Page/Page column 105; 106, (2015/11/17)
This invention relates to antibacterial and anti-mycobacterial drug compounds of formula I. It also relates to pharmaceutical formulations of antibacterial drug compounds. It also relates to uses of the derivatives in treating bacterial infections and to methods of treating bacterial infections. The invention is also directed to antibacterial drug compounds which are capable of treating bacterial infections which are currently hard to treat with existing drug compounds, e.g. those caused by resistant bacterial or mycobacterial strains.
SULFONAMIDE DERIVATIVE AND MEDICINAL USE THEREOF
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Paragraph 0673-0675, (2015/02/25)
Provided are sulfonamide derivatives of a specific chemical structure in which a sulfonamide group having, as a substituent, a phenyl group or a heterocyclic group having a hetero atom(s) as a constituent element(s) is present at its terminal, and pharmaceutically acceptable salts thereof. These compounds are novel compounds having excellent α4 integrin-inhibitory action.
BIARYL ACYL-SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS
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Paragraph 00316, (2015/04/22)
The present invention provides compounds of Formula (Ia), and pharmaceutically acceptable salts thereof. The compounds are useful as inhibitors of voltage-gated sodium channels, in particular Nav 1.7. (Ia); as described in the specification. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention, as well as intermediates and processes useful for making the compounds.