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4-bromo-2,5-difluorobenzoic acid is a type of aromatic halogen compound with a molecular formula of C7H3BrF2O2. It is characterized by the presence of both bromine (bromo) and fluorine (fluoro) components, which contribute to its distinct chemical properties. 4-bromo-2,5-difluorobenzoic acid exhibits acid properties due to the presence of a carboxyl group (-COOH). The unique combination of these halogens provides opportunities for varied interactions with other chemical entities, making it a valuable research chemical. It appears as a crystalline solid under room conditions.

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  • 28314-82-1 Structure
  • Basic information

    1. Product Name: 4-bromo-2,5-difluorobenzoic acid
    2. Synonyms: 4-bromo-2,5-difluorobenzoic acid;Benzoic acid, 4-broMo-2,5-difluoro-;2,5-Difluoro-4-broMobenzoic acid
    3. CAS NO:28314-82-1
    4. Molecular Formula: C7H3BrF2O2
    5. Molecular Weight: 236.9983264
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 28314-82-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 285.0±40.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.872±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. PKA: 2.70±0.10(Predicted)
    10. CAS DataBase Reference: 4-bromo-2,5-difluorobenzoic acid(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-bromo-2,5-difluorobenzoic acid(28314-82-1)
    12. EPA Substance Registry System: 4-bromo-2,5-difluorobenzoic acid(28314-82-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 28314-82-1(Hazardous Substances Data)

28314-82-1 Usage

Uses

Used in Organic Synthesis:
4-bromo-2,5-difluorobenzoic acid is used as a building block for the synthesis of various organic compounds. The presence of both bromine and fluorine in the benzoic acid structure can greatly affect the compound's reactivity, making it a versatile starting material for the preparation of a wide range of chemical products.
Used in Research Chemicals:
4-bromo-2,5-difluorobenzoic acid is used as a research chemical in laboratories. Its unique properties and reactivity make it a valuable tool for studying chemical reactions and processes, as well as for the development of new synthetic methods and techniques.
Used in Pharmaceutical Industry:
4-bromo-2,5-difluorobenzoic acid is used as an intermediate in the synthesis of pharmaceutical compounds. Its chemical properties and reactivity can be exploited to create new drug molecules with potential therapeutic applications.
Used in Material Science:
4-bromo-2,5-difluorobenzoic acid is used in the development of new materials with specific properties. The incorporation of bromine and fluorine into the benzoic acid structure can lead to the creation of materials with unique characteristics, such as improved stability, enhanced reactivity, or altered physical properties, which can be useful in various applications.

Check Digit Verification of cas no

The CAS Registry Mumber 28314-82-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,3,1 and 4 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 28314-82:
(7*2)+(6*8)+(5*3)+(4*1)+(3*4)+(2*8)+(1*2)=111
111 % 10 = 1
So 28314-82-1 is a valid CAS Registry Number.

28314-82-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Bromo-2,5-difluorobenzoic acid

1.2 Other means of identification

Product number -
Other names 2,5-difluoro-4-bromo-benzoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:28314-82-1 SDS

28314-82-1Relevant articles and documents

ANTIBACTERIAL COMPOUNDS AND NEW USES THEREOF

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Page/Page column 97; 98, (2017/04/11)

This invention relates to a series of compounds of formula (I) for use in treating infections caused by obligate anaerobic bacteria, including Clostridium difficile, and to methods of treating said infections by administering said compounds. The compounds can be used against strains of obligate anaerobic bacteria that have developed resistance to other antibiotics. Many compounds used in the invention contain a tricyclic ring system.

ANTIBACTERIAL COMPOUNDS

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Page/Page column 66-67, (2017/04/11)

This invention relates to antibacterial and anti-mycobacterial drug compounds of formula (I). It also relates to pharmaceutical formulations of antibacterial drug compounds of formula (I). It also relates to uses of the derivatives in treating bacterial i

In vitro and in vivo identification of novel positive allosteric modulators of the human dopamine D2 and D3 receptor

Wood, Martyn,Ates, Ali,Andre, Veronique Marie,Michel, Anne,Barnaby, Robert,Gillard, Michel

supporting information, p. 303 - 312 (2016/02/26)

Agonists at dopamine D2 and D3 receptors are important therapeutic agents in the treatment of Parkinson's disease. Compared with the use of agonists, allosteric potentiators offer potential advantages such as temporal, regional, and phasic potentiation of

SULFONAMIDE DERIVATIVE AND PHARMACEUTICAL USE THEREOF

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Paragraph 0236; 0237; 0238, (2016/09/26)

Provided is a sulfonamide derivative represented by the following general formula (1) and having an α4 integrin inhibitory effect with high selectivity with a low effect on α4β1 and a high effect on α4β7, or a pharmaceutically acceptable salt thereof (in the general formula (1), A, B, D, E, R41, and a to h are as described in the description).

CARBAZOLE DERIVATIVES

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Page/Page column 72; 73, (2016/05/24)

Disclosed are compounds of Formula (I): (I) or a salt thereof, wherein Q, R1a, R1b, R2a, R2b, R3, R4, R5a, R5b, R6a, R6c, R7a, R7b, R7c, and R7d are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

INDOLE CARBOXAMIDE COMPOUNDS

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Paragraph 0297-0298, (2016/05/19)

Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR4 or N; R1, R2, R3, R4, and A are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

TRICYCLIC ATROPISOMER COMPOUNDS

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Page/Page column 49-50, (2016/06/06)

Disclosed are compounds of Formula (I): or a salt thereof, wherein Q is: or; and X, R1a, R1b, R3, R4, and R5 are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bru

ANTIBACTERIAL COMPOUNDS

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Page/Page column 105; 106, (2015/11/17)

This invention relates to antibacterial and anti-mycobacterial drug compounds of formula I. It also relates to pharmaceutical formulations of antibacterial drug compounds. It also relates to uses of the derivatives in treating bacterial infections and to methods of treating bacterial infections. The invention is also directed to antibacterial drug compounds which are capable of treating bacterial infections which are currently hard to treat with existing drug compounds, e.g. those caused by resistant bacterial or mycobacterial strains.

SULFONAMIDE DERIVATIVE AND MEDICINAL USE THEREOF

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Paragraph 0673-0675, (2015/02/25)

Provided are sulfonamide derivatives of a specific chemical structure in which a sulfonamide group having, as a substituent, a phenyl group or a heterocyclic group having a hetero atom(s) as a constituent element(s) is present at its terminal, and pharmaceutically acceptable salts thereof. These compounds are novel compounds having excellent α4 integrin-inhibitory action.

BIARYL ACYL-SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS

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Paragraph 00316, (2015/04/22)

The present invention provides compounds of Formula (Ia), and pharmaceutically acceptable salts thereof. The compounds are useful as inhibitors of voltage-gated sodium channels, in particular Nav 1.7. (Ia); as described in the specification. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders. Also provided are pharmaceutical compositions containing compounds of the present invention, as well as intermediates and processes useful for making the compounds.

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