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4-(3-Aminophenoxy)-N-methylpicolinamide is a chemical compound with the molecular formula C12H12N3O. It is a derivative of picolinamide, featuring an aminophenoxy group at the 4-position and a methyl group at the nitrogen atom. 4-(3-Aminophenoxy)-N-methylpicolinamide is known for its potential applications in medicinal chemistry, particularly as a building block for the synthesis of various pharmaceuticals. Its structure allows for the exploration of different biological activities, making it a subject of interest in drug discovery and development. The compound's specific properties and reactivity can be further investigated to understand its role in chemical reactions and its potential therapeutic uses.

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  • 284462-78-8 Structure
  • Basic information

    1. Product Name: 4-(3-Aminophenoxy)-N-methylpicolinamide
    2. Synonyms: 2-Pyridinecarboxamide, 4-(3-aminophenoxy)-N-methyl-;
    3. CAS NO:284462-78-8
    4. Molecular Formula: C13H13N3O2
    5. Molecular Weight: 243.265
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 284462-78-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 472.2 °C at 760 mmHg
    3. Flash Point: 239.4 °C
    4. Appearance: N/A
    5. Density: 1.241 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-(3-Aminophenoxy)-N-methylpicolinamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-(3-Aminophenoxy)-N-methylpicolinamide(284462-78-8)
    11. EPA Substance Registry System: 4-(3-Aminophenoxy)-N-methylpicolinamide(284462-78-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 284462-78-8(Hazardous Substances Data)

284462-78-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 284462-78-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,4,4,6 and 2 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 284462-78:
(8*2)+(7*8)+(6*4)+(5*4)+(4*6)+(3*2)+(2*7)+(1*8)=168
168 % 10 = 8
So 284462-78-8 is a valid CAS Registry Number.

284462-78-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(3-aminophenoxy)-N-methylpyridine-2-carboxamide

1.2 Other means of identification

Product number -
Other names 4-(3-aminophenoxy)-pyridine-2-carbonic acid methyl amide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:284462-78-8 SDS

284462-78-8Relevant articles and documents

POLYAROMATIC UREA DERIVATIVES AND THEIR USE IN THE TREATMENT OF MUSCLE DISEASES

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, (2021/01/29)

The current invention provides urea derivatives, in particular compounds having the core structure heteroaryl-NH-CO-NH-aryl-O- heteroaryl, for use in treating, ameliorating, delaying, curing and/ or preventing a disease or condition associated with muscle cells and/or satellite cells, such as Duchenne muscular dystrophy, Becker muscular dystrophy, cachexia or sarcopenia.

Design, synthesis and biological activities of sorafenib derivatives as antitumor agents

Yao, Jianwen,He, Zuopeng,Chen, Jing,Sun, Wei,Fang, Hao,Xu, Wenfang

, p. 6549 - 6553,5 (2012/12/12)

A series of novel sorafenib derivatives, 9a-w, was designed and synthesized in high yields using various substituted anilines, and their antiproliferative activities against HCT116, PC-3 and MDA-MB-231 cell lines were also evaluated and described. All compounds exhibited potent antiproliferative activity against HCT116 and PC-3 cells with IC50 = 2.8-52.0 and 2.2-45.6 μM; compounds 9p and 9q demonstrated competitive antiproliferative activities to sorafenib against all three cancer cell lines, the cytotoxicity of compound 9r is more potent than that of sorafenib. Compounds (9g, 9p, 9q and 9r) were chosen for further evaluation of the anti-angiogenesis activity, and showed the inhibition of sprout formation from aortic ring ex vivo. The structures of all the newly synthesized compounds were determined by 1H NMR, 13C NMR and HRMS.

NOVEL SUBSTITUTED PYRIDINYLOXY AND PYRIMIDINYLOXY AMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES

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Page/Page column 13; 20, (2010/11/27)

The present invention relates to compounds and methods useful as inhibitors of protein kinases, including B-Raf and several receptor tyrosine and cytoplasmic tyrosine kinases. The present invention is directed to new substituted pyrimidinyloxy urea compounds of Formulas II, III and IV and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulating of protein kinase activity in a human or animal subject are also provided for the treatment diseases such as cancers.

PYRIMIDINE DERIVATIVES FOR TREATMENT OF HYPERPROLIFERATIVE DISORDERS

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Page/Page column 42, (2010/11/23)

Pyrimidine derivatives of formula (I), pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are disclosed and claimed.

BENZIMIDAZOLE CARBOXAMIDES AS RAF KINASE INHIBITORS

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Page/Page column 132, (2008/06/13)

The present invention relates to benzimidazole carboxamides of formula (I), the use of the compounds of formula (I) as inhibitors of as inhibitors of one or more kinases, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient. Accordingly, the compound of Formula (I) or a pharmaceutically acceptable salt thereof is administered for the treatment of diseases mediated by one or more kinase phathways, preferably by the raf kinase pathway, especially cancers.

SEMICARBAZIDE DERIVATIVES AS KINASE INHIBITORS

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Page/Page column 203, (2008/06/13)

The present invention relates to semicarbazide derivatives of formula I, the use of the compounds of formula I as inhibitors of one or more kinases, the use of the compounds of formula I for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.

MALONAMIDE DERIVATIVES

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Page 171, (2010/02/10)

The present invention relates to malonamide derivatives of formula (I): A-D-B, the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.

BISARYLUREA DERIVATIVES

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Page/Page column 177-179, (2010/02/13)

The present invention relates to bisarylurea derivatives of formula (I), the use of the compounds of formula (I) as inhibitors of raf-kinase, the use of the compounds of formula (I) for the manufacture of a pharmaceutical composition and a method of treatment, comprising administering said pharmaceutical composition to a patient.

PYRIMIDINE DERIVATIVES FOR TREATMENT OF HYPERPROLIFERATIVE DISORDERS

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Page/Page column 57, (2008/06/13)

Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G', and G" represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.

OMEGA-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS

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Page/Page column 23, (2010/01/31)

This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.

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