284493-89-6

Basic information

• Product Name: 3-[(4-chlorophenyl)sulfanyl]-1-(4-methoxyphenyl)-3-phenyl-1-propanone
• Synonyms: 3-[(4-chlorophenyl)sulfanyl]-1-(4-methoxyphenyl)-3-phenyl-1-propanone
• CAS NO: 284493-89-6
• Molecular Formula: C22H19ClO2S
• Molecular Weight: 382.90306
• Mol File: 284493-89-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-[(4-chlorophenyl)sulfanyl]-1-(4-methoxyphenyl)-3-phenyl-1-propanone(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[(4-chlorophenyl)sulfanyl]-1-(4-methoxyphenyl)-3-phenyl-1-propanone(284493-89-6)
• EPA Substance Registry System: 3-[(4-chlorophenyl)sulfanyl]-1-(4-methoxyphenyl)-3-phenyl-1-propanone(284493-89-6)

Safety Data

• Hazardous Substances Data: 284493-89-6(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 106-54-7 p-Chlorothiophenol 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 959-23-9 4'-methoxychalcone 

Relevant articles and documents

Design and synthesis of 1,3-biarylsulfanyl derivatives as new anti-breast cancer agents

A new series of 1,3-biarylsulfanyl derivatives (homodibenzyl core motif) have been designed and synthesized as new estrogen receptor ligands by chopping benzothiophene core of raloxifene to engender seco-raloxifene scaffold. All the synthesized compounds were screened for anti-proliferative, anti-osteoporotic, and anti-implantation activity. Compounds (35, 36) having basic amino anti-estrogenic side chain were exhibiting potential anti-proliferative activity in MCF-7, MDA-MB-231 and ishikawa cell lines. Some of the synthesized compounds having homodibenzyl motif (5, 8, 10) have shown moderate anti-osteoporotic activity.

A mild and highly efficient one-pot three-component reaction for carbon-sulfur bond formation catalyzed by potassium tert-butoxide

Potassium tert-butoxide has been found to be a highly efficient catalyst for one-pot, three-component reaction of aryl aldehydes, acetophenones, and thiols via Claisen-Schmidt/Michael addition reactions for the synthesis of thia-Michael adducts in high yields. The reactions are best carried out in tert-butyl alcohol at room temperature.

Multicomponent, solvent-free synthesis of β-aryl-β-mercapto ketones using zirconium chloride as a catalyst

Zirconium chloride efficiently catalyzes the one-pot, three-component reaction of an aryl aldehyde, cyclic or acyclic enolizable ketones, and thiols under solvent-free conditions at room temperature to afford the corresponding β-aryl-β-mercaptoketones via aldol-Michael addition reactions. This methodology affords a large number of β-aryl-β-mercapto ketone derivatives in high yields and in short reaction times.