286932-31-8

Basic information

• Product Name: 2-CHLORO-4-FLUOROCHALCONE
• Synonyms: 2-CHLORO-4-FLUOROCHALCONE
• CAS NO: 286932-31-8
• Molecular Formula: C15H10ClFO
• Molecular Weight: 260.69
• Mol File: 286932-31-8.mol

Chemical Properties

• Melting Point: 86 °C
• Boiling Point: 372.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.265±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-CHLORO-4-FLUOROCHALCONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-FLUOROCHALCONE(286932-31-8)
• EPA Substance Registry System: 2-CHLORO-4-FLUOROCHALCONE(286932-31-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 286932-31-8(Hazardous Substances Data)

Upstream product

• 84194-36-5 2-chloro-4-fluorobenzaldehyde 
• 98-86-2 acetophenone 

Relevant articles and documents

Application of Polyphosphoric Acid-Mediated Acyl Migration for Regiospecific Synthesis of Diverse 2-Acylpyrroles from Chalcones

A metal-free approach for the synthesis of 2-acylpyrroles is reported in this paper. Synthesis of the target molecule started from chalcones and was carried out in two steps. Initial step involved the conversion of chalcones to corresponding 4-substituted-3-acylpyrroles by reaction with TosMIC. In the subsequent step, target molecules were obtained in modest to good yields by polyphosphoric acid-mediated acyl rearrangement of 3-acylpyrroles to their 2-acyl congeners. The crucial final step was amenable to diverse substitutions on pyrrole ring. Preliminary experiment for the determination of mechanism indicated the involvement of acylium ion.

Rh(II)-Catalyzed Nitrene-Transfer [5 + 1] Cycloadditions of Aryl-Substituted Vinylcyclopropanes

Formal [5 + 1] cycloadditions between aryl-substituted vinylcyclopropanes and nitrenoid precursors are reported. The method, which employs Rh2(esp)2 as a catalyst, leads to the highly regioselective formation of substituted tetrahydropyridines. Preliminary mechanistic studies support a stepwise, polar mechanism enabled by the previously observed Lewis acidity of Rh-nitrenoids. Overall, this work expands the application of nitrene-transfer cycloaddition, a relatively underexplored approach to heterocycle synthesis, to the formation of six-membered rings.