A fluorescent histone deacetylase (HDAC) inhibitor for cellular imaging
Fluorescence microscopy studies using 4-morpholinoscriptaid (4MS) demonstrated rapid cellular uptake of this scriptaid analogue into the cytoplasm but no nuclear penetration. As 4MS and scriptaid have the same in vitro activity against HDACs and KASUMI-1 cells; 4MS exemplifies a rational approach to subtly modify 'profluorogenic' substrates for intracellular studies.
Fleming, Cassandra L.,Ashton, Trent D.,Nowell, Cameron,Devlin, Mark,Natoli, Anthony,Schreuders, Jeannette,Pfeffer, Frederick M.
supporting information
p. 7827 - 7830
(2015/05/13)
FILAGGRIN PRODUCTION PROMOTER, THERAPEUTIC AGENT FOR DISEASES ASSOCIATED WITH REDUCTION IN PRODUCTION OF FILAGGRIN, AND METHOD FOR SCREENING FOR SAID THERAPEUTIC AGENT
The present invention provides a highly effective substance having a filaggrin production-promoting action. The present invention also provides a therapeutic agent useful for treating a skin disease, in particular, atopic dermatitis associated with reduce
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Page/Page column
(2015/06/16)
A convenient synthesis of the new histone deacetylase inhibitor scriptaid
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Gerova, Mariana S.,Petrov, Ognyan I.
p. 76 - 79
(2014/03/21)
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