287383-59-9 Usage
Uses
Used in Pharmaceutical Industry:
SCRIPTAID is used as a histone deacetylase inhibitor for its ability to facilitate transcriptional activation (TGFβ/Smad4) in both stable and transient receptor assays in a concentration-dependent manner.
Used in Cancer Research:
SCRIPTAID is used as an anticancer agent, inhibiting tumor growth in vitro and in vivo, and inducing cell cycle arrest in colon cancer cells in culture.
Used in Reproductive Biology:
SCRIPTAID is used in post-activation of oocytes and embryo culture, facilitating the cloning of inbred mouse strains produced by somatic cell nuclear transfer.
Biological Activity
Novel histone deacetylase inhibitor. Produces > 100-fold increase in histone acetylation and displays relatively low toxicity.
Biochem/physiol Actions
Histone deacetylase inhibitor with lower toxicity than trichostatin A; used to enhance protein expression.
References
1) Su?et al.?(2000),?A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library; Cancer Res.,?60?3137
2) Huber?et al.?(2011),?Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells; J. Biol. Chem.,?286?22211
3) Lee?et al.?(2008),?Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells; J. Oncol.,?33?767
4) Rissi?et al.?(2019),?Inhibition of RNA synthesis during Scriptaid exposure enhances gene reprogramming in SCNT embryos; Reproduction,?157?123
5) Huang?et al.?(2020),?Scriptaid/exercise-induced lysine acetylation is another type of posttranslational modification occurring in titin; J. Appl. Physiol.,?128?276
Check Digit Verification of cas no
The CAS Registry Mumber 287383-59-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,7,3,8 and 3 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 287383-59:
(8*2)+(7*8)+(6*7)+(5*3)+(4*8)+(3*3)+(2*5)+(1*9)=189
189 % 10 = 9
So 287383-59-9 is a valid CAS Registry Number.
InChI:InChI=1/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)
287383-59-9Relevant articles and documents
FILAGGRIN PRODUCTION PROMOTER, THERAPEUTIC AGENT FOR DISEASES ASSOCIATED WITH REDUCTION IN PRODUCTION OF FILAGGRIN, AND METHOD FOR SCREENING FOR SAID THERAPEUTIC AGENT
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Page/Page column, (2015/06/16)
The present invention provides a highly effective substance having a filaggrin production-promoting action. The present invention also provides a therapeutic agent useful for treating a skin disease, in particular, atopic dermatitis associated with reduce
A fluorescent histone deacetylase (HDAC) inhibitor for cellular imaging
Fleming, Cassandra L.,Ashton, Trent D.,Nowell, Cameron,Devlin, Mark,Natoli, Anthony,Schreuders, Jeannette,Pfeffer, Frederick M.
supporting information, p. 7827 - 7830 (2015/05/13)
Fluorescence microscopy studies using 4-morpholinoscriptaid (4MS) demonstrated rapid cellular uptake of this scriptaid analogue into the cytoplasm but no nuclear penetration. As 4MS and scriptaid have the same in vitro activity against HDACs and KASUMI-1 cells; 4MS exemplifies a rational approach to subtly modify 'profluorogenic' substrates for intracellular studies.
