287401-07-4Relevant articles and documents
Synthesis of Scabronines and Analogues Thereof
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Page/Page column 19-20, (2009/07/25)
A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. T
INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-A MODULATORS; SYNTHESES OF SUCH MODULATORS AND METHODS OF USING SUCH MODULATORS
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Page/Page column 65-66; 122-123; Sheet 4/69; 10/69; 12/69; 16/69, (2010/11/25)
Compounds are disclosed that have the chemical structure of Formula (II), (IIA) and (IIB) and their prodrug esters and acid-addition salts, and that are useful as Interleukin-1 and Tumor Necrosis Factor-a modulators, and thus are useful in the treatment of various diseases, wherein the R groups are defined in the claims.
SYNTHESIS OF SCABRONINES AND ANALOGUES THEREOF
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Page/Page column 51; 2/10, (2008/06/13)
A novel synthesis of scabronines, which are related to a broader class of angularly fused tricyclic diterpenoids known as cyathanes, is provided. Scabronine G, its methyl ester derivative, and other analogs have been shown to have neurotrophic activity. T
Total synthesis of (-)-scabronine G, an inducer of neurotrophic factor production
Waters, Stephen P.,Tian, Yuan,Li, Yue-Ming,Danishefsky, Samuel J.
, p. 13514 - 13515 (2007/10/03)
The total synthesis of (-)-scabronine G has been achieved in a concise manner from the (-)-Wieland-Miescher ketone. Scabronine G and its more potent methyl ester (also prepared) display activity as nonpeptidyl inducers of nerve growth factor production. C
Interleukin-1 and tumor necrosis factors-α modulators, syntheses of said modulators and methods of using modulators
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Page column 29, (2008/06/13)
Novel compounds are disclosed that have the chemical structure of Formula (IIB), and its prodrug esters and acid-addition salts, and that are useful as Interleukin-1 and Tumor Necrosis Factor-α modulators, and thus are useful in the treatment of various d
Enantioselective synthesis of the antiinflammatory agent (-)-acanthoic acid
Ling,Chowdhury,Kramer,Vong,Palladino,Theodorakis
, p. 8843 - 8853 (2007/10/03)
An enantioselective synthesis of the potent antiinflammatory agent (-)-acanthoic acid (1) is described. The successful strategy departs from (-)-Wieland-Miescher ketone (10), which is readily available in both enantiomeric forms and constitutes the starting point toward a fully functionalized AB ring system of 1. Conditions were developed for a regioselective double alkylation at the C4 center of the A ring, which produced compound 32 as a single stereoisomer. Construction of the C ring of 1 was accomplished via a Diels-Alder reaction between sulfur-containing diene 43 and methacrolein (36), which after desulfurization and further functionalization yielded synthetic acanthoic acid. The described synthesis confirms the proposed stereochemistry of the natural product and represents a fully stereocontrolled entry into an underexplored class of biologically active diterpenes.
Stereoselective synthesis of (-)-acanthoic acid.
Ling,Kramer,Palladino,Theodorakis
, p. 2073 - 2076 (2007/10/03)
[reaction: see text] The first stereoselective synthesis of (-)-acanthoic acid (1) has been designed and accomplished. Our synthetic plan departs from (-) Wieland-Miesher ketone (7) and calls upon a Diels-Alder cycloaddition reaction for the construction
