28917-44-4Relevant articles and documents
Dicarbonyl chelates from 1-cymantrenylalkylamides with the dendrite structure: formation, photochromism, and kinetics of dark reaction with carbon monoxide
Kelbysheva,Telegina,Abramova,Strelkova,Ikonnikov,Rodionov,Ezernitskaya,Lokshin,Loim
, p. 2646 - 2654 (2016/10/03)
Photolysis of carboxamides of the dendrite structure with aminomethyland 1-aminoethylcymantrenes leads to the formation of six-membered dicarbonyl chelates with the Mn—O bond which are stable in solutions. The chelates in the reversed dark reaction with carbon monoxide give the starting tricarbonyl complexes. The formation of the chelates and their dark reaction are accompanied by the reversible change of color by the compounds. The rate determining step of the thermal reaction of chelates with CO is a chelate ring opening with the ligand substitution by the SN1 mechanism. A possibility of solvent-free photoinduced ligand-exchange reaction in a number of cymantrene derivatives was demonstrated.
A facile preparation of α-aryl carboxylic acid via one-flow arndt-eistert synthesis
Fuse, Shinichiro,Otake, Yuma,Mifune, Yuto,Tanaka, Hiroshi
, p. 1657 - 1661 (2015/11/10)
An efficient, one-flow Arndt-Eistert synthesis was demonstrated. A sequence of acid chloride formation-nucleophilic acyl substitution-Wolff rearrangement-nucleophilic addition was performed in a microflow system without isolating any intermediates, which
A new synthesis of 4′-resveratrol esters and evaluation of the potential for anti-depressant activity
Acerson, Mark J.,Fabick, Kimberly M.,Wong, Yong,Blake, Crystal,Lephart, Edwin D.,Andrus, Merritt B.
, p. 2941 - 2944 (2013/06/27)
The 4′-ester analog of the disease preventative resveratrol 1 (RV), 4′-acetyl-RV 2 along with 4′-pivaloate 13 and benzoate 14 RV were synthesized. The previously developed palladium catalyzed decarbonylative Heck coupling was used to assemble the stilbene core together with 3,5-dibenzyl protected phenol intermediates that allowed for efficient coupling and deprotection using boron trifluoride etherate. Studies with Long-Evans rats were performed to establish safety, toxicity, and behavioral parameters. In addition, the Porsalt forced-swim test was used to demonstrate anti-depressant activity.
Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl) -6-pyrrolidinylquinolin-4-one as a potent anticancer lead
Cheng, Yung-Yi,Liu, Chin-Yu,Tsai, Meng-Tung,Lin, Hui-Yi,Yang, Jai-Sing,Wu, Tian-Shung,Kuo, Sheng-Chu,Huang, Li-Jiau,Lee, Kuo-Hsiung
, p. 5223 - 5227 (2013/09/12)
New 6- (or 6,7-) substituted 2-(hydroxyl substituted phenyl)quinolin-4-one derivatives were synthesized and screened for antiproliferative effects against cancer cell lines. Structure-activity relationship correlations were established and the most promis
Novel inhibitors of basal glucose transport as potential anticancer agents
Zhang, Weihe,Liu, Yi,Chen, Xiaozhuo,Bergmeier, Stephen C.
scheme or table, p. 2191 - 2194 (2010/06/15)
Cancer cells commonly show increased levels of glucose uptake and dependence. A potential strategy for the treatment of cancer may be the inhibition of basal glucose transport. We report here the synthesis of a small library of polyphenolic esters that inhibit basal glucose transport in H1299 lung and other cancer cells. These basal glucose transport inhibitors also inhibit cancer cell growth in H1299 cells, and these two activities appear to be correlated.
HETEROARYL BENZAMIDE DERIVATIVES FOR USE AS GLK ACTIVATORS IN THE TREATMENT OF DIABETES
-
Page/Page column 108; 109, (2008/06/13)
Compounds of formula (I), wherein R1, R4, HET-1 and HET-2 are as described in the specification, and their salts and pro-drugs, are activators of glucokinase (GLK) and are thereby useful in the treatment of, for example, type 2 diabetes. Processes for preparing compounds of formula (I) are also described.
Synthesis of alternating polystyrene/poly(ethyleneoxide) branched polymacromonomers
Deimede, Valadoula,Kallitsis, Joannis K.
, p. 467 - 473 (2007/10/03)
Newly designed PS/PEO alternating branched polymacromonomers have been obtained by polycondensation of α-dicarboxy-functionalized polystyrene and α-dihydroxy-functionalized polyethyleneoxide. 4-[3,5-Bis-(methoxycarbonyl)phenoxymethyl]benzyl bromide was used as atom-transfer radical polymerization (ATRP) initiator for the synthesis of α-dicarboxy functionalized polystyrenes. These macromonomers possess low polydispersities and molecular weights in the range of 7000 to 100000, as proved by gel permeation chromatography (GPC) and 1H NMR. α-Dihydroxy functionalized polyethyleneoxide (PEO) was synthesized by treatment of monofunctionalized PEO with 3,5-bis(benzyloxy)benzoyl chloride. Polycondensation of the α-dicarboxy PS with the α-dihydroxy PEO in solution or in bulk resulted in alternating PS/PEO polymacromonomers, which were effectively purified from the unreacted macromonomers and characterized by using 1H NMR, GPC, thermal analysis, and optical microscopy. Light-scattering measurements in organic solvents like THF or dioxane have shown that these polymacromonomers form stable micelles.
Solid-phase synthesis using (Allyloxy)carbonyl(Alloc) chemistry of a putative heptapeptide intermediate in vancomycin biosynthesis containing m-chloro-3-hydroxytyrosine
Freund, Ernst,Vitali, Francesca,Linden, Anthony,Robinson, John A.
, p. 2572 - 2579 (2007/10/03)
A convenient method for the solid-phase synthesis of putative linear heptapeptide intermediates in vancomycin biosynthesis is described, in particular, the heptapeptide D-Leu-Cyt-L-Asn-Hpg-Hpg-Cyt'-Dhpg (Cyt = (2R,3R)-m-chloro-3-hydroxytyrosine, Hpg = (R)-2-(p-hydroxyphenyl)glycine, Cyt' = (2S,3R)-m-chloro-3-hydroxytyrosine and Dhpg = (S)-2-(3,5-dihydroxyphenyl)glycine). The synthesis was performed on chlorotrityl resin and employed the (allyloxy)carbonyl protecting group for temporary N(α) protection during peptide-chain assembly.
Synthesis and chiroptical properties of dendrimers elaborated from a chiral, nonracemic central core
Chaumette, Jean-Louis,Laufersweiler, Matthew J.,Parquette, Jon R.
, p. 9399 - 9405 (2007/10/03)
Three generations of ester-terminated dendrimers have been constructed from (1R,2S)-2-amino-1-phenyl-1,3-propanediol, 1, as the central core. The chiroptical properties of the dendrimers were measured revealing that the molar rotations [Φ] of the dendrimers decreased with increasing dendrimer generation. Comparison to a series of substituted benzoate derivatives of 1 suggested that the decrease in rotation was a consequence of a steric effect upon the conformational equilibrium of the central core that increased with increasing dendrimer generation. The optical rotations of dendrimers 7-9 were also observed to be solvent and temperature dependent.
