- BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT
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The present invention is directed to a compound of Formula (I) or a pharmaceutically acceptable salt thereof; wherein R, R1, R2, R3, R4, m, and n are as defined herein, to pharmaceutical compositions comprising said compound, and to methods of treating diseases or conditions mediated by elevated persistent sodium current, such as an ocular disorder, multiple sclerosis, seizure disorder, and chronic pain.
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Page/Page column 38
(2013/07/19)
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- 5-ALKYLOXY-INDOLIN-2-ONE DERIVATIVES, PREPARATION THEREOF AND APPLICATION THEREOF IN THERAPY
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The present invention relates to derivatives of 5-alkyloxy-indolin-2-one, their method of production and their therapeutic applications. These novel derivatives have affinity and selectivity for the V2 receptors of vasopressin (“V2 receptors”) and can therefore constitute active principles of pharmaceutical compositions.
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Page/Page column 9
(2010/04/23)
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- BENZIMIDAZOLES WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE
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Compounds of formula (I), salts and solvates are provided: formula (I), wherein Q, R and R6 are as defined in the claims. Uses of the compounds for therapy, for example in the treatment of psychotic disorders and cognitive impairment, are also disclosed.
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Page/Page column 126
(2008/06/13)
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- Positive allosteric modulators of the nicotinic acetylcholine receptor
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The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals used to treat diseases or conditions in which α7 nAChR is known to be involved.
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- REACTION OF AROMATIC COMPOUNDS WITH NUCLEOPHILIC REAGENTS IN LIQUID AMMONIA. VI. ORIENTATION IN THE REACTIONS OF 2,4-DIFLUORONITROBENZENE WITH ALKALI-METAL ALCOHOLATES AND PHENOLATES
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On the basis of the results from a study of the orientation during the substitution of a fluorine atom in 2,4-difluoronitrobenzene by the action of nucleophiles of the ROM type (R = Me, Et, i-Pr, Ph; M = Na, K) and its temperature dependence for the reactions with sodium methoxide and sodium phenolate in liquid ammonia at -70 to -33 deg C it was shown that the enthalpy control of the ratio of the substitution rates of the fluorine atoms at the ortho and para positions to the nitro group, which was previously found in the reactions of o- and p-fluoronitrobenzenes with sodium methoxide in liquid ammonia, is general.It was shown that the preference for substitution at the ortho position under these conditions increases with change in the nature of the alcoholate in the order MeO- - -.This is evidently due primarily to the increase in the polarizability of the alkyl group of alcoholate in the same order.
- Kizner, T. A.,Shteingarts, V. D.
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p. 2173 - 2178
(2007/10/02)
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