28987-48-6

Usage

Uses

Used in Pharmaceutical Industry:
4-Ethoxy-2-fluoro-1-nitrobenzene is used as an intermediate in the synthesis of pharmaceutical compounds for its ability to contribute to the development of new drugs. Its specific functional groups allow for targeted modifications and the creation of molecules with desired therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Ethoxy-2-fluoro-1-nitrobenzene is utilized as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its structural features enable the creation of molecules with specific pesticidal or herbicidal activities, contributing to the development of effective crop protection agents.
Used in Materials Science:
4-Ethoxy-2-fluoro-1-nitrobenzene is employed as a building block in the synthesis of materials with specialized properties for use in various applications within materials science. Its incorporation into polymers, for instance, can lead to materials with improved characteristics such as thermal stability, mechanical strength, or chemical resistance.
Safety Note:
It is crucial to handle 4-Ethoxy-2-fluoro-1-nitrobenzene with care, as it may pose hazards if not used properly. Adequate safety measures and precautions should be taken during its synthesis, storage, and application to ensure the safety of both individuals and the environment.

InChI:InChI=1/C8H8FNO3/c1-2-13-6-3-4-8(10(11)12)7(9)5-6/h3-5H,2H2,1H3

Upstream product

• 446-35-5 2,4-Difluoronitrobenzene 
• 917-58-8 potassium ethoxide 
• 141-52-6 sodium ethanolate 
• 64-67-5 diethyl sulfate 
• 394-41-2 3-fluoro-4-nitrophenol 
• 75-03-6 ethyl iodide 

Downstream Products

• 950773-10-1 N-[5-(ethyloxy)-2-nitrophenyl]-1-[trans-1-methyl-4-(methyloxy)cyclohexyl]-4-piperidinamine 
• 950773-12-3 N-[5-(ethyloxy)-2-nitrophenyl]-1-[trans-1-methyl-4-(ethyloxy)cyclohexyl]-4-piperidinamine 
• 625119-94-0 tert-butyl 4-(5-ethoxy-2-nitrophenyl)piperazine-1-carboxylate 
• 1032816-53-7 2-(2-chloro-phenyl)-2-(5-ethoxy-2-nitro-phenyl)methyl propionate 
• 1041259-36-2 methyl 2-(2-chlorophenyl)-2-(5-ethoxy-2-nitrophenyl)butyrate 
• 1446338-17-5 (2-amino-5-ethoxyphenyl)(2-methylpropyl)amine 
• 1446338-18-6 2-(4-chlorophenoxy)-N-{4-ethoxy-2-[(2-methylpropyl)amino]phenyl}acetamide 
• 1446337-69-4 4-chloro-1-{[6-ethoxy-1-(2-methylpropyl)benzimidazole-2-yl]methoxy}benzene 
• 1446338-20-0 N-{4-ethoxy-2-[(2-methylpropyl)amino]phenyl}-2(phenylamino)acetamide 
• 1446337-71-8 {[6-ethoxy-1-(2-methylpropyl)benzimidazole-2-yl]methyl}phenylamine 
• 950773-11-2 4-(ethyloxy)-N₂-{1-[trans-1-methyl-4-(methyloxy)cyclohexyl]-4-piperidinyl}-1,2-benzenediamine 
• 950773-13-4 4-(ethyloxy)-N₂-{1-[trans-1-methyl-4-(ethyloxy)cyclohexyl]-4-piperidinyl}-1,2-benzenediamine 

Relevant academic research and scientific papers

BENZIMIDAZOLE DERIVATIVES AS SELECTIVE BLOCKERS OF PERSISTENT SODIUM CURRENT

The present invention is directed to a compound of Formula (I) or a pharmaceutically acceptable salt thereof; wherein R, R1, R2, R3, R4, m, and n are as defined herein, to pharmaceutical compositions comprising said compound, and to methods of treating diseases or conditions mediated by elevated persistent sodium current, such as an ocular disorder, multiple sclerosis, seizure disorder, and chronic pain.

5-ALKYLOXY-INDOLIN-2-ONE DERIVATIVES, PREPARATION THEREOF AND APPLICATION THEREOF IN THERAPY

The present invention relates to derivatives of 5-alkyloxy-indolin-2-one, their method of production and their therapeutic applications. These novel derivatives have affinity and selectivity for the V2 receptors of vasopressin (“V2 receptors”) and can therefore constitute active principles of pharmaceutical compositions.

BENZIMIDAZOLES WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE

Compounds of formula (I), salts and solvates are provided: formula (I), wherein Q, R and R6 are as defined in the claims. Uses of the compounds for therapy, for example in the treatment of psychotic disorders and cognitive impairment, are also disclosed.

Positive allosteric modulators of the nicotinic acetylcholine receptor

The invention provides compounds of Formula I: These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals used to treat diseases or conditions in which α7 nAChR is known to be involved.

REACTION OF AROMATIC COMPOUNDS WITH NUCLEOPHILIC REAGENTS IN LIQUID AMMONIA. VI. ORIENTATION IN THE REACTIONS OF 2,4-DIFLUORONITROBENZENE WITH ALKALI-METAL ALCOHOLATES AND PHENOLATES

On the basis of the results from a study of the orientation during the substitution of a fluorine atom in 2,4-difluoronitrobenzene by the action of nucleophiles of the ROM type (R = Me, Et, i-Pr, Ph; M = Na, K) and its temperature dependence for the reactions with sodium methoxide and sodium phenolate in liquid ammonia at -70 to -33 deg C it was shown that the enthalpy control of the ratio of the substitution rates of the fluorine atoms at the ortho and para positions to the nitro group, which was previously found in the reactions of o- and p-fluoronitrobenzenes with sodium methoxide in liquid ammonia, is general.It was shown that the preference for substitution at the ortho position under these conditions increases with change in the nature of the alcoholate in the order MeO- - -.This is evidently due primarily to the increase in the polarizability of the alkyl group of alcoholate in the same order.